Animal and clinical study for Treatment of Asthma using Intranasal inhalation of Himalayan salt / (Record no. 607328)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 03572nam a22001577a 4500 |
| 082 ## - DEWEY DECIMAL CLASSIFICATION NUMBER | |
| Classification number | 610 |
| 100 ## - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Tariq, Ayesha |
| 245 ## - TITLE STATEMENT | |
| Title | Animal and clinical study for Treatment of Asthma using Intranasal inhalation of Himalayan salt / |
| Statement of responsibility, etc. | Ayesha Tariq |
| 264 ## - PRODUCTION, PUBLICATION, DISTRIBUTION, MANUFACTURE, AND COPYRIGHT NOTICE | |
| Place of production, publication, distribution, manufacture | Islamabad : |
| Name of producer, publisher, distributor, manufacturer | SMME- NUST; |
| Date of production, publication, distribution, manufacture, or copyright notice | 2023. |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 56p. |
| Other physical details | Soft Copy |
| Dimensions | 30cm |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | Asthma is a non-communicable disease (NCD) that affects airways by narrowing their diameter and<br/>eventually causing inflammation in lungs. This has become one of the most frequently diagnosed<br/>disorders in the past few decades. In addition, more death due to asthma is recorded in low income<br/>countries where treatment is a challenge due to related cost. The purpose of this study is to investigate<br/>effects of salt therapy in asthma disease based on clinical study by using human specimen and vet lab<br/>study by using Wister rats as asthma model. A cross-sectional survey-based and experimental study was<br/>conducted on asthma patients at the Khewra salt mines sanatorium. The survey-based study comprised<br/>107 patients of which 8 were randomly selected for experimental study. Patients of both genders from<br/>ages 2 months to 55 years were part of this study. Participants were asked to stay in the Khewra salt<br/>mines sanatorium for 10 hours for 10 days. CBC test was performed before and after salt therapy to<br/>check the role of pulmonary immune cells in asthmatic patients for diagnostic purposes. Statistical<br/>analysis was made based on immune cell count including platelets, eosinophils, monocytes, neutrophils,<br/>and lymphocytes. Moreover, in vet lab based study, rats are extensively used as asthma model globally,<br/>for this study 5 treatment groups of Wister rats were used. Asthma was induced in rats by combination<br/>of Ovalbumin (OVA), alum and Phosphate Buffer Saline (PBS) solution and then diseased rats were<br/>exposed to intranasal inhalation of salt aerosols of different concentrations (0.5%, 1%, 3%, 5% and 6%)<br/>of pink salt solution for treatment purpose. For obtaining findings, blood samples from their hearts were<br/>collected for complete Blood Count (CBC) test for immune cells analysis. The rats were later dissected<br/>for histological analysis of lungs. The results of survey-based study indicate that salt therapy is emerged<br/>as an advanced treatment method for asthma patients as it reduces frequency of asthma attacks and<br/>minimizes use of medication. It was also observed that after salt therapy count of immune cells<br/>decreased in all 8 patients. The results of paired sample t-test gave a p-value of less than 0.05 in the case<br/>of all 5 immune cell counts, which shows salt therapy is an effective treatment for asthma patients. Vet<br/>lab study results show that body weight significantly increased from the start of treatment phase to the<br/>end of experiment in all treatment groups. However, lung weight analysis revealed remarkable decrease<br/>in diseased rats. CBC tests show a significant decrease in immune cells count of treatment rat groups<br/>with different aerosols concentrations. The histological results of different treatment groups were then<br/>compared with normal and diseased rats. It is observed that salt treatment proves to be significantly<br/>effective way for treating asthma through intranasal salt aerosols inhalation. This study shows that salt<br/>therapy can be used as a treatment for asthma. |
| 650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | MS Biomedical Sciences (BMS) |
| 700 ## - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Supervisor : Dr. Amer Sohail Kashif |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="http://10.250.8.41:8080/xmlui/handle/123456789/34702">http://10.250.8.41:8080/xmlui/handle/123456789/34702</a> |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | |
| Koha item type | Thesis |
| Withdrawn status | Permanent Location | Current Location | Shelving location | Date acquired | Full call number | Barcode | Koha item type |
|---|---|---|---|---|---|---|---|
| School of Mechanical & Manufacturing Engineering (SMME) | School of Mechanical & Manufacturing Engineering (SMME) | E-Books | 12/13/2023 | 610 | SMME-TH-875 | Thesis |