Age-Specific Study of Airflow Distribution, Aerosol Transport and Deposition in an Unhealthy Human Lung using CFD-DPM Approach / (Record no. 607332)
[ view plain ]
| 000 -LEADER | |
|---|---|
| fixed length control field | 02400nam a22001577a 4500 |
| 082 ## - DEWEY DECIMAL CLASSIFICATION NUMBER | |
| Classification number | 621 |
| 100 ## - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Riaz, Hafiz Hamza |
| 245 ## - TITLE STATEMENT | |
| Title | Age-Specific Study of Airflow Distribution, Aerosol Transport and Deposition in an Unhealthy Human Lung using CFD-DPM Approach / |
| Statement of responsibility, etc. | Hafiz Hamza Riaz |
| 264 ## - PRODUCTION, PUBLICATION, DISTRIBUTION, MANUFACTURE, AND COPYRIGHT NOTICE | |
| Place of production, publication, distribution, manufacture | Islamabad : |
| Name of producer, publisher, distributor, manufacturer | SMME- NUST; |
| Date of production, publication, distribution, manufacture, or copyright notice | 2023. |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 58p. |
| Other physical details | Soft Copy |
| Dimensions | 30cm |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | The pulmonary route is the pathway to transport aerosolised drug particles into the<br/>tracheobronchial airways to treat and prevent respiratory diseases. Lung cancer is a frequently<br/>diagnosed respiratory disease caused by particulate matter in the environment, especially among<br/>older individuals. It is evident that as age increases, the lung airway diameters reduce, and this<br/>geometric alteration due to aging affects the breathing capacity, transportation, and deposition<br/>(TD) of inhaled drugs. A precise understanding of the inhaled particles TD through age-specific<br/>unhealthy respiratory tracts containing a tumor can potentially optimise lung cancer treatment,<br/>especially among aged individuals, which has not been investigated in the existing literature.<br/>This study investigates the aging effect on the deposition of inhaled drug particles on the glomus<br/>tumor present in the upper airways of the human respiratory tract. The CFD model predicts that<br/>particle deposition on the tumor wall is higher in the 70-year-old lung for the particle sizes<br/>ranging from 5-10 μm, while the maximum deposition efficiency of 10-20 μm particles is found<br/>in the lung of a 50-year-old individual. The results of the numerical study show that particle sizes<br/>ranging from 10-14 μm are deposited with higher efficiency on the tumor wall as compared to<br/>the smaller size particles (5-9 μm) for 50, 60 and, 70 age. The flow disturbances are found<br/>maximum in the airway downstream of the tumor. Furthermore, the effect of different inhalation<br/>flow rates on particles (TD) is also investigated. The obtained patterns of airflow distribution and<br/>deposition efficiency on the tumor wall and in the upper tracheobronchial airways would be<br/>beneficial for developing an efficient and targeted drug delivery system. |
| 650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | MS Mechanical Engineering |
| 700 ## - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Supervisor : Dr. Adnan Munir |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="http://10.250.8.41:8080/xmlui/handle/123456789/34603">http://10.250.8.41:8080/xmlui/handle/123456789/34603</a> |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | |
| Koha item type | Thesis |
| Withdrawn status | Permanent Location | Current Location | Shelving location | Date acquired | Full call number | Barcode | Koha item type |
|---|---|---|---|---|---|---|---|
| School of Mechanical & Manufacturing Engineering (SMME) | School of Mechanical & Manufacturing Engineering (SMME) | E-Books | 12/13/2023 | 621 | SMME-TH-871 | Thesis |