Genetic Screening for the Prevalence of PRNP Mutations in Pakistan / (Record no. 607437)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 02159nam a22001577a 4500 |
| 082 ## - DEWEY DECIMAL CLASSIFICATION NUMBER | |
| Classification number | 610 |
| 100 ## - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Khalid, Minahil |
| 245 ## - TITLE STATEMENT | |
| Title | Genetic Screening for the Prevalence of PRNP Mutations in Pakistan / |
| Statement of responsibility, etc. | Minahil Khalid |
| 264 ## - PRODUCTION, PUBLICATION, DISTRIBUTION, MANUFACTURE, AND COPYRIGHT NOTICE | |
| Place of production, publication, distribution, manufacture | Islamabad : |
| Name of producer, publisher, distributor, manufacturer | SMME- NUST; |
| Date of production, publication, distribution, manufacture, or copyright notice | 2023. |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 83p. |
| Other physical details | Soft Copy |
| Dimensions | 30cm |
| 500 ## - GENERAL NOTE | |
| General note | Prion diseases are highly contagious, rapidly progressive, and extremely life-threatening<br/>neuronal condition. CJD is the prime example of prion disease. Many cases of CJD have<br/>been reported up till now. It can be acquired, inherited or sporadic in nature. sCJD<br/>accounts for the highest prevalence globally i.e., 85% of the cases, gCJD encompasses<br/>10-15% of the cases whereas iCJD cases include 1-2%. Its long incubation period (10-12<br/>years) and short disease duration (3-12 months) makes it difficult to diagnose, which has<br/>contributed to higher death toll since its occurrence. World organizations are strictly<br/>monitoring CJD cases, in order to curtail the spread of this fatal disease but they are far<br/>behind in eradicating it completely. Hence it is imperative to identify CJD sources to<br/>reduce the number of cases. Therefore, this present research is the first initiative to assess<br/>the prevalence of CJD in Pakistani population. Results of this study indicated absence of<br/>mutation at codon 200 in the participants under study. Most prevalent genotype were<br/>M129-E200 (71%) and V129-E200 (29%) whereas M129-K200 and V129-K200 were<br/>absent in the participants. In parallel study a survey encompassing questions related to<br/>cognitive impaired just like CJD was also carried out to assess public knowledge<br/>regarding it. Results indicated that educated groups lacked knowledge in theoretical as<br/>well as non-theoretical aspects of CJD. This study is highly significant as it provides<br/>preliminary data on the susceptible cases of CJD and proof that the public knowledge<br/>also corresponds to the data gathered by genetic screening |
| 650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | MS Biomedical Sciences (BMS) |
| 700 ## - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Supervisor : Dr. Aneeqa Noor |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="http://10.250.8.41:8080/xmlui/handle/123456789/32675">http://10.250.8.41:8080/xmlui/handle/123456789/32675</a> |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | |
| Koha item type | Thesis |
| Withdrawn status | Permanent Location | Current Location | Shelving location | Date acquired | Full call number | Barcode | Koha item type |
|---|---|---|---|---|---|---|---|
| School of Mechanical & Manufacturing Engineering (SMME) | School of Mechanical & Manufacturing Engineering (SMME) | E-Books | 01/18/2024 | 610 | SMME-TH-842 | Thesis |