Assessment of APOE Genotype in Pakistani Population with Relevance to Rapidly Progressive Alzheimer’s Disease / (Record no. 607439)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 02485nam a22001577a 4500 |
| 082 ## - DEWEY DECIMAL CLASSIFICATION NUMBER | |
| Classification number | 610 |
| 100 ## - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Rasheed, Urwah |
| 245 ## - TITLE STATEMENT | |
| Title | Assessment of APOE Genotype in Pakistani Population with Relevance to Rapidly Progressive Alzheimer’s Disease / |
| Statement of responsibility, etc. | Urwah Rasheed |
| 264 ## - PRODUCTION, PUBLICATION, DISTRIBUTION, MANUFACTURE, AND COPYRIGHT NOTICE | |
| Place of production, publication, distribution, manufacture | Islamabad : |
| Name of producer, publisher, distributor, manufacturer | SMME- NUST; |
| Date of production, publication, distribution, manufacture, or copyright notice | 2023. |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 68p. |
| Other physical details | Soft Copy |
| Dimensions | 30cm |
| 500 ## - GENERAL NOTE | |
| General note | According to the statistics provided by World Health Organization (WHO), approximately<br/>55 million people are suffering from dementia globally making it a major public health<br/>concern. Alzheimer’s Disease (AD) is the most common cause of dementia constituting<br/>60-70% of cases worldwide. There are various environmental and genetic risk factors that<br/>contribute to the development of AD, among the genetic risk factors, APOE polymorphism<br/>is the major risk factor for AD. There are three isoforms of APOE gene E2, E3, and E4.<br/>The presence of different isoforms of APOE gene in different genotypical combinations<br/>determine how susceptible is the person to developing AD in the future. AD affects the<br/>patient’s quality of life severely and makes even basic chores undoable, therefore it is<br/>imperative for people to be aware of the disease and stay clear of the myths surrounding it.<br/>The present study is the first one to assess the presence of APOE genotype in Pakistani<br/>population with relevance to AD, no study of this sort has been carried out in Pakistan<br/>before. The results showed complete absence of E2 allele in the tested population size. The<br/>most prevalent allele was E3 which was expressed in the form of E3E3 (95%) and E3E4<br/>(5%) genotypes. E4/E4 genotype was also completely absent. In this study, a detailed<br/>survey was also conducted to assess the knowledge of AD in Pakistani people. In certain<br/>non-technical areas, the respondents exhibited good knowledge about the AD, but in the<br/>technical aspects where risk factors, diagnostic criteria and treatment options related to the<br/>disease were involved, the participants displayed poor knowledge, this shows that even the<br/>educated people in Pakistan are unaware about the basic knowledge of the disease. It is<br/>imperative to establish organizations that can create awareness among the masses regarding<br/>AD which is exponentially increasing in Pakistan. |
| 650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | MS Biomedical Sciences (BMS) |
| 700 ## - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Supervisor : Dr. Aneeqa Noor |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="http://10.250.8.41:8080/xmlui/handle/123456789/32676">http://10.250.8.41:8080/xmlui/handle/123456789/32676</a> |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | |
| Koha item type | Thesis |
| Withdrawn status | Permanent Location | Current Location | Shelving location | Date acquired | Full call number | Barcode | Koha item type |
|---|---|---|---|---|---|---|---|
| School of Mechanical & Manufacturing Engineering (SMME) | School of Mechanical & Manufacturing Engineering (SMME) | E-Books | 01/18/2024 | 610 | SMME-TH-841 | Thesis |