Effect of Etoposide loaded Nanoparticles in the Treatment of Advanced Liver Diseases / (Record no. 607470)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 02068nam a22001577a 4500 |
| 082 ## - DEWEY DECIMAL CLASSIFICATION NUMBER | |
| Classification number | 610 |
| 100 ## - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Iqbal, Zarqa |
| 245 ## - TITLE STATEMENT | |
| Title | Effect of Etoposide loaded Nanoparticles in the Treatment of Advanced Liver Diseases / |
| Statement of responsibility, etc. | Zarqa Iqbal |
| 264 ## - PRODUCTION, PUBLICATION, DISTRIBUTION, MANUFACTURE, AND COPYRIGHT NOTICE | |
| Place of production, publication, distribution, manufacture | Islamabad : |
| Name of producer, publisher, distributor, manufacturer | SMME- NUST; |
| Date of production, publication, distribution, manufacture, or copyright notice | 2023. |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 76p. |
| Other physical details | Soft Copy |
| Dimensions | 30cm |
| 500 ## - GENERAL NOTE | |
| General note | Advanced liver diseases (ALD) continue to pose significant health challenges due to their<br/>high global prevalence and limited currently available curative options, besides liver<br/>transplantation. Liver disease therapeutics include many substances that may have<br/>insufficient effectiveness and severe adverse effects, such as Etoposide, having toxic<br/>nature with low compatibility and solubility in an aqueous solution. Nanoparticle-based<br/>therapeutics emerged as an efficient and safe treatment option to minimize side effects.<br/>Etoposide used for ALD is more toxic with low biocompatibility and solubility in an<br/>aqueous solution which makes it less efficient. The purpose of the study is to use<br/>nanoparticle-based etoposide for the treatment of ALD by improving its biocompatibility<br/>and solubility which makes this target-based therapy less toxic and more effective. Rat<br/>models used in this study were introduced with CCL4 and Urethane co-administration to<br/>develop liver cirrhosis. The thin film hydration method was used to synthesize etoposideencapsulated liposomal nanoparticles. The stability and stealth effect of liposomes were<br/>enhanced by polyethylene glycol (PEG) coating. Etoposides and PEG-coated etoposide<br/>liposomes were administered intravenously, into diseased rats. Results showed that<br/>etoposide and PEG-coated liposomal encapsulation are highly effective as compared to<br/>etoposide alone and blank nanoparticles and hence, be a substantial strategy for the<br/>treatment of ALD through intravenous drug delivery system. |
| 650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | MS Biomedical Sciences (BMS) |
| 700 ## - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Supervisor : Dr. Nosheen Fatima Rana |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="http://10.250.8.41:8080/xmlui/handle/123456789/32405">http://10.250.8.41:8080/xmlui/handle/123456789/32405</a> |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | |
| Koha item type | Thesis |
| Withdrawn status | Permanent Location | Current Location | Shelving location | Date acquired | Full call number | Barcode | Koha item type |
|---|---|---|---|---|---|---|---|
| School of Mechanical & Manufacturing Engineering (SMME) | School of Mechanical & Manufacturing Engineering (SMME) | E-Books | 01/22/2024 | 610 | SMME-TH-827 | Thesis |