LIPOSOMAL DOXORUBICIN FOR THE TREATMENT OF ADVANCED LIVER DISEASE / (Record no. 607717)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 02771nam a22001577a 4500 |
| 082 ## - DEWEY DECIMAL CLASSIFICATION NUMBER | |
| Classification number | 610 |
| 100 ## - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Khan, Faryal |
| 245 ## - TITLE STATEMENT | |
| Title | LIPOSOMAL DOXORUBICIN FOR THE TREATMENT OF ADVANCED LIVER DISEASE / |
| Statement of responsibility, etc. | Faryal Khan |
| 264 ## - PRODUCTION, PUBLICATION, DISTRIBUTION, MANUFACTURE, AND COPYRIGHT NOTICE | |
| Place of production, publication, distribution, manufacture | Islamabad : |
| Name of producer, publisher, distributor, manufacturer | SMME- NUST; |
| Date of production, publication, distribution, manufacture, or copyright notice | 2022. |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 59p. |
| Other physical details | Soft Copy |
| Dimensions | 30cm |
| 500 ## - GENERAL NOTE | |
| General note | Nanoscale materials are utilized as diagnostic instruments or to administer therapeutic substances<br/>to specific targeted regions in a controlled manner in the fields of nanomedicine and nano drug<br/>carriers, which are still relatively young but are quickly evolving. Nanoparticles can potentially<br/>deliver medications more accurately because they are currently made from biocompatible<br/>materials. The treatment of advanced liver disease has benefited greatly from nanomedicine in<br/>previous decades. Nano-based drug delivery systems improve the effectiveness of medications.<br/>Today, advanced liver disease is being treated with liposomal nanoparticles. Nano-based drug<br/>delivery systems increase the efficacy of both new and existing treatments through a detailed<br/>investigation of nanoparticle manufacturing and utilization.<br/>One of the most often used anticancer medications is doxorubicin. Doxorubicin (DOX) is a<br/>medication that is frequently used to treat HCC. Doxorubicin is a medicine that belongs to the<br/>anthracyclines class and is commonly used to treat different types of cancers, including lymphomas,<br/>leukemias, breast, ovary, thyroid, and lungs.<br/>Doxorubicin interacts with nitrogen - containing bases of DNA and prevents the production of<br/>macromolecules. This, in turn, prevents the action of the enzyme topoisomerase II (Top II), which<br/>inhibits the replication process. Consequently, malignant cells are prevented from proliferating.<br/>According to early research, doxorubicin's cardiotoxicity is reduced when it is encapsulated inside<br/>liposomes.<br/>Due to its cardiotoxicity, the "thin film hydration approach" was utilized to create doxorubicinencapsulated liposome nanoparticles, which were then used to treat advanced liver disease. The<br/>liposome nanoparticles were coated with polyethylene glycol (PEG) to boost their stability and<br/>provide a stealth effect. Pegylation improves steric repulsion and is therefore regarded as a superior<br/>stabilizer for various kinds of nanoparticles. PEG adopts the drug's erosion-controlled release<br/>mechanism, which led to continuous release. It is noted that a significant technique to treat NAFLD<br/>is to encapsulate the doxorubicin drug within liposomes and modify these liposome nanoparticles<br/>via PEG. |
| 650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | MS Biomedical Sciences (BMS) |
| 700 ## - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Supervisor : Dr. Nosheen Fatima Rana |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="http://10.250.8.41:8080/xmlui/handle/123456789/32271">http://10.250.8.41:8080/xmlui/handle/123456789/32271</a> |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | |
| Koha item type | Thesis |
| Withdrawn status | Permanent Location | Current Location | Shelving location | Date acquired | Full call number | Barcode | Koha item type |
|---|---|---|---|---|---|---|---|
| School of Mechanical & Manufacturing Engineering (SMME) | School of Mechanical & Manufacturing Engineering (SMME) | E-Books | 02/14/2024 | 610 | SMME-TH-816 | Thesis |