Oral Administration of Fluoxetine Incorporated Liposomal Nanoparticles coated with PEG in Treatment of Chronic Mild stress (CMS) / (Record no. 607719)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 02704nam a22001577a 4500 |
| 082 ## - DEWEY DECIMAL CLASSIFICATION NUMBER | |
| Classification number | 610 |
| 100 ## - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Sadiq, Nadia |
| 245 ## - TITLE STATEMENT | |
| Title | Oral Administration of Fluoxetine Incorporated Liposomal Nanoparticles coated with PEG in Treatment of Chronic Mild stress (CMS) / |
| Statement of responsibility, etc. | Nadia Sadiq |
| 264 ## - PRODUCTION, PUBLICATION, DISTRIBUTION, MANUFACTURE, AND COPYRIGHT NOTICE | |
| Place of production, publication, distribution, manufacture | Islamabad : |
| Name of producer, publisher, distributor, manufacturer | SMME- NUST; |
| Date of production, publication, distribution, manufacture, or copyright notice | 2022. |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 55p. |
| Other physical details | Soft Copy |
| Dimensions | 30cm |
| 500 ## - GENERAL NOTE | |
| General note | Depression is one of the most increasing psychological mood disorders, depression does not have<br/>some specific physical symptoms, but it negatively affects the person mood, way of living and<br/>thinking chronic mild stress (CMS) is one of its type, depression is affecting more than 300million<br/>people in the world. Shortness of breath, headache, being miserable, stomach disturbance and<br/>physical tensions are some of the common symptoms of depression that is reported according to<br/>National Alliance of Mental Health, Anti-depressant are used for altering the neurotransmitters<br/>those are serotonin, dopamine and norepinephrine that are primarily involved in regulating and<br/>mood alleviating mood. Despite the availability of large number of drugs, many of patients are<br/>resistant to the current mode of treatment that are available now adays. The obstacle that is<br/>significant for the transportation of beneficial therapeutic entities to the nervous system is BBB<br/>that is the blood brain barrier. There are junctions that are present in the endothelial cells of the<br/>blood brain barrier that stop the drugs passage. Now nanoparticles are receiving significant<br/>limelight owing to their small size and efficient brain targeting activity, making them likely to<br/>cross the blood brain barrier while carrying the intact drug molecule otherwise incapable of<br/>permeation. In this study the fluoxetine loaded liposomal nanoparticle coated with PEG were<br/>developed to transport the drug across the BBB to the central nervous system having much greater<br/>efficiency. For testing its delivery, the animal that is mice model of depression is used with the<br/>specific name that is designed in order to induce depression like symptoms in mice. Before and<br/>After treatment great differences between the physical behaviors like Elevated maze, open field<br/>test, force swim test etc and sucrose consumption test were identified and plotted, as liposomes<br/>that having capabilities to carry the anti-depressant drug molecule that is administered through the<br/>Oral route of administration or the better and improved method of treatment. |
| 650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | MS Biomedical Engineering (BME) |
| 700 ## - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Supervisor : Dr. Nosheen Fatima Rana |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="http://10.250.8.41:8080/xmlui/handle/123456789/32264">http://10.250.8.41:8080/xmlui/handle/123456789/32264</a> |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | |
| Koha item type | Thesis |
| Withdrawn status | Permanent Location | Current Location | Shelving location | Date acquired | Full call number | Barcode | Koha item type |
|---|---|---|---|---|---|---|---|
| School of Mechanical & Manufacturing Engineering (SMME) | School of Mechanical & Manufacturing Engineering (SMME) | E-Books | 02/14/2024 | 610 | SMME-TH-815 | Thesis |