Prevalence of APP-associated novel polymorphism in Pakistani Population / (Record no. 607828)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 01798nam a22001577a 4500 |
| 082 ## - DEWEY DECIMAL CLASSIFICATION NUMBER | |
| Classification number | 610 |
| 100 ## - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Maryam, Ammara |
| 245 ## - TITLE STATEMENT | |
| Title | Prevalence of APP-associated novel polymorphism in Pakistani Population / |
| Statement of responsibility, etc. | Ammara Maryam |
| 264 ## - PRODUCTION, PUBLICATION, DISTRIBUTION, MANUFACTURE, AND COPYRIGHT NOTICE | |
| Place of production, publication, distribution, manufacture | Islamabad : |
| Name of producer, publisher, distributor, manufacturer | SMME- NUST; |
| Date of production, publication, distribution, manufacture, or copyright notice | 2024. |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 70p. |
| Other physical details | Soft Copy |
| Dimensions | 30cm |
| 500 ## - GENERAL NOTE | |
| General note | Alzheimer’s disease is a prevalent neurodegenerative disease characterized by dementia occurs in<br/>aged individuals. The report of prevalence of AD showed that AD and dementia patients are<br/>estimated as 35.6 million in 2010 and this number can reach up to 66 million by 2030.<br/>The present study is the first one to assess the presence of APP genotype in the Pakistani population<br/>with relevance to AD, and structural analysis of wild type APP, 710 (V>G) and 718 (I>L), and<br/>720 (L>S) mutated APP with ligands (BACE1, ADAM10, and Nicastrin). No study of this sort<br/>has been carried out in Pakistan before. The in silico results showed that mutated APP at 718 codon<br/>interacts with serine residue of BACE1, and tyrosine residue with Nicastrin. Change in these<br/>residues cause protein to undergo aberrant denaturing and results in generation of amyloids due to<br/>differential binding of mutated APP protein with ligands in AD. SNP analysis showed the<br/>prevalence of 718 (I>L) mutation in 4% of studied population. Symptoms of 718 (I>L), mutation<br/>in APP are Hippocampus atrophy, dementia with remarkable oral tendency, and Amnesia. It is<br/>imperative to establish organizations that can create awareness among the masses regarding AD<br/>which is exponentially increasing in Pakistan. |
| 650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | MS Biomedical Sciences (BMS) |
| 700 ## - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Supervisor : Dr. Aneeqa Noor |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="http://10.250.8.41:8080/xmlui/handle/123456789/42199">http://10.250.8.41:8080/xmlui/handle/123456789/42199</a> |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | |
| Koha item type | Thesis |
| Withdrawn status | Permanent Location | Current Location | Shelving location | Date acquired | Full call number | Barcode | Koha item type |
|---|---|---|---|---|---|---|---|
| School of Mechanical & Manufacturing Engineering (SMME) | School of Mechanical & Manufacturing Engineering (SMME) | E-Books | 02/16/2024 | 610 | SMME-TH-986 | Thesis |