Polycaprolactone Nanoparticle Encapsulating Antifouling Ceftaroline for Enhanced In-vitro Controlled Drug Release / (Record no. 607829)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 02451nam a22001577a 4500 |
| 082 ## - DEWEY DECIMAL CLASSIFICATION NUMBER | |
| Classification number | 610 |
| 100 ## - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Hanif, Naeema |
| 245 ## - TITLE STATEMENT | |
| Title | Polycaprolactone Nanoparticle Encapsulating Antifouling Ceftaroline for Enhanced In-vitro Controlled Drug Release / |
| Statement of responsibility, etc. | Naeema Hanif |
| 264 ## - PRODUCTION, PUBLICATION, DISTRIBUTION, MANUFACTURE, AND COPYRIGHT NOTICE | |
| Place of production, publication, distribution, manufacture | Islamabad : |
| Name of producer, publisher, distributor, manufacturer | SMME- NUST; |
| Date of production, publication, distribution, manufacture, or copyright notice | 2024. |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 79p. |
| Other physical details | Soft Copy |
| Dimensions | 30cm |
| 500 ## - GENERAL NOTE | |
| General note | Globally, infectious diseases are among the top ten significant contributors to large number of fatalities<br/>affecting both developed and developing countries evenly. It has been challenging to treat infections<br/>like skin infections due to the global trend of developing antibiotic resistance. In context of this,<br/>antibiotics that are effective against both gram-positive and gram-negative organisms and have a long<br/>half-life as well as high tissue permeability are needed. Cefepime, a member of the fourth generation<br/>intravenous cephalosporins, is one such antibiotic. However, the intravenous administration of drug has<br/>restricted the supply of drug to the intended area i.e., skin, instead reaches directly to the blood.<br/>This draws attention to the significance of developing a drug delivery system that stays at the skin surface<br/>while regulating drug absorption, boosts the drug's bioavailability, and lessens the requirement for<br/>frequent drug usage. The current research focuses on developing a chitosan nano-carrier using the ionic<br/>gelation method, subsequently transformed into carbopol gel for more effective, longer-lasting skin drug<br/>release. SEM analysis shows the spherical morphology of chitosan/alginate nanoparticles with sizes of<br/>156±12.75nm and 222±56nm for both blank and drug-loaded nanoparticles, respectively. Positive<br/>zetapotential i.e., 18.2mV indicates polycationic chitosan matrix of the nano-capsules. Finally, the in-vitro<br/>drug release study manifested controlled drug release at two different pH (5.5 and 7.4) for a period of<br/>24h. Furthermore, antibacterial activity of nano-formulation as well as the gel was observed against both<br/>+Ve and -Ve bacterial strains with better zones of inhibition. The obtained data significantly pointed out<br/>that the cefepime nanoparticles loaded carbopol gel would be an encouraging choice for skin infections. |
| 650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | MS Biomedical Science (BMS) |
| 700 ## - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Supervisor : Dr. Nabeel Anwar |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="http://10.250.8.41:8080/xmlui/handle/123456789/42140">http://10.250.8.41:8080/xmlui/handle/123456789/42140</a> |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | |
| Koha item type | Thesis |
| Withdrawn status | Permanent Location | Current Location | Shelving location | Date acquired | Full call number | Barcode | Koha item type |
|---|---|---|---|---|---|---|---|
| School of Mechanical & Manufacturing Engineering (SMME) | School of Mechanical & Manufacturing Engineering (SMME) | E-Books | 02/16/2024 | 610 | SMME-TH-984 | Thesis |