Effect of PEG coating on the Vitexin liposomes for Oral treatment of ALD / (Record no. 607922)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 02216nam a22001577a 4500 |
| 082 ## - DEWEY DECIMAL CLASSIFICATION NUMBER | |
| Classification number | 610 |
| 100 ## - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Iqbal, Arfa |
| 245 ## - TITLE STATEMENT | |
| Title | Effect of PEG coating on the Vitexin liposomes for Oral treatment of ALD / |
| Statement of responsibility, etc. | Arfa Iqbal |
| 264 ## - PRODUCTION, PUBLICATION, DISTRIBUTION, MANUFACTURE, AND COPYRIGHT NOTICE | |
| Place of production, publication, distribution, manufacture | Islamabad : |
| Name of producer, publisher, distributor, manufacturer | SMME- NUST; |
| Date of production, publication, distribution, manufacture, or copyright notice | 2022. |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 56p. |
| Other physical details | Soft Copy |
| Dimensions | 30cm |
| 500 ## - GENERAL NOTE | |
| General note | Vitexin a natural flavonoid, occasionally used in pharmaceutics due to its variety of medicinal<br/>effects and its roles in fat metabolism, hepatoprotection, and anticancer therapies. It has been<br/>rendered important for diseases leading to chronic liver disease, such as NASH/NAFLD,<br/>diabetes, cardiovascular ailments, and Liver cirrhosis. Recently, it has been administered in pure<br/>drug formulation, in combination with other chemicals, and nanoparticulate form mostly<br/>intravenously for various types of liver diseases. In its pure form it shows lower bioavailability<br/>due to its insolubility in aqueous environments and a lower rate of intestinal absorption. Since<br/>vitexin is known for its role in reducing and reversing the complications arising from<br/>decompensated liver cirrhosis, liposomal nanoparticles encapsulating vitexin were prepared by<br/>the ‘thin-film hydration’ process along with passive drug loading. Polyethylene glycol (PEG)<br/>coating of vitexin-loaded nanoparticles was used in the oral treatment of advanced liver disease<br/>in this research. Wistar rat models of intense liver injury was prepared and treated with vitexinloaded liposomal nanoparticles coated with PEG-1000 and PEG-2000. Histopathological,<br/>serological analysis and various other parameters observed and analyzed during and after the<br/>disease induction and completion of the treatment protocol presented better results and a possible<br/>reversal of liver cirrhosis when nanoparticles were coated with PEG-2000 in oral treatment.<br/>PEG-2000 also shows positive role in the oral administration to match the effectiveness of<br/>previously used vitexin-loaded nanoparticles for intravenous treatment of liver cirrhosis. |
| 650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | MS Biomedical Sciences |
| 700 ## - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Supervisor : Dr. Nosheen Fatima Rana |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="http://10.250.8.41:8080/xmlui/handle/123456789/31846">http://10.250.8.41:8080/xmlui/handle/123456789/31846</a> |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | |
| Koha item type | Thesis |
| Withdrawn status | Permanent Location | Current Location | Shelving location | Date acquired | Full call number | Barcode | Koha item type |
|---|---|---|---|---|---|---|---|
| School of Mechanical & Manufacturing Engineering (SMME) | School of Mechanical & Manufacturing Engineering (SMME) | E-Books | 02/20/2024 | 610 | SMME-TH-807 | Thesis |