Human Placental-Derived Extracellular Matrix Sheets as Scaffolds for Cell Growth in Cornea Transplantation: A Promising Approach in Regenerative medicine / (Record no. 608258)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 03109nam a22001577a 4500 |
| 082 ## - DEWEY DECIMAL CLASSIFICATION NUMBER | |
| Classification number | 610 |
| 100 ## - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Khan, Unaiza Ali |
| 245 ## - TITLE STATEMENT | |
| Title | Human Placental-Derived Extracellular Matrix Sheets as Scaffolds for Cell Growth in Cornea Transplantation: A Promising Approach in Regenerative medicine / |
| Statement of responsibility, etc. | Unaiza Ali Khan |
| 264 ## - PRODUCTION, PUBLICATION, DISTRIBUTION, MANUFACTURE, AND COPYRIGHT NOTICE | |
| Place of production, publication, distribution, manufacture | Islamabad : |
| Name of producer, publisher, distributor, manufacturer | SMME- NUST; |
| Date of production, publication, distribution, manufacture, or copyright notice | 2024. |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 121p. |
| Other physical details | Soft Copy |
| Dimensions | 30cm |
| 500 ## - GENERAL NOTE | |
| General note | Eye is a sensory organ designed for human vision. Its intricate components work<br/>together to make the process of sight possible. The cornea is a critical part of the eye<br/>responsible for clear vision, and corneal diseases or injuries can lead to visual impairment<br/>or blindness. However, the limited availability of suitable donor tissue poses a significant<br/>challenge. There is a significant influence on the quality of life when the visual acuity is<br/>reduced. In terms of the overall prevalence of blindness and visual impairment Pakistan<br/>ranks third position, following the India and Bangladesh across all age groups, totaling<br/>21.78 million. Placenta-derived extracellular matrix (ECM) sheets have become an<br/>effective therapeutic approach due to their rich composition of bioactive molecules, growth<br/>factors, and supportive microenvironment for tissue regeneration. The unique composition<br/>of placental-derived ECM sheets can provide a favorable microenvironment for the growth<br/>of corneal cell and promote the regeneration of corneal tissue. In this study amniotic<br/>membrane sheets, have been prepared by decellularizing placental tissue and different<br/>characterization techniques have been used for a thorough examination of the human<br/>amniotic membrane. Scanning Electron Microscopy (SEM) reveals intricate surface<br/>features, while Hematoxylin and Eosin (H&E) staining provides insights into tissue<br/>architecture. Fourier Transform Infrared Spectroscopy (FTIR) offers a detailed<br/>examination of biochemical composition. Microbial activity testing provides valuable<br/>information of the membrane's antimicrobial properties. A p-value < 0.05 in the ANOVA<br/>analysis indicated a significant difference in antimicrobial activity among the three<br/>bacterial strains. The characterization approaches utilized in this study contribute to a betterxx<br/>knowledge of the biological characteristics of the human amniotic membrane, paving the<br/>path for advances in regenerative medicine and tissue engineering. In this study a human<br/>placental-derived extracellular matrix (ECM) sheets have been used to investigate the<br/>integration potential of the ECM sheets with host corneal tissue. The positive outcome was<br/>associated with a noticeable reduction in size of corneal defect due to the application of<br/>amniotic membrane transplant. The use of AM proved to be essential in reducing notable<br/>subjective symptoms like pain, as well as clinical signs such as redness and the size of<br/>corneal ulcers. |
| 650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | MS Biomedical Sciences (BMS) |
| 700 ## - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Supervisor : Dr. Muhammad Asim Waris |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="http://10.250.8.41:8080/xmlui/handle/123456789/42270">http://10.250.8.41:8080/xmlui/handle/123456789/42270</a> |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | |
| Koha item type | Thesis |
| Withdrawn status | Permanent Location | Current Location | Shelving location | Date acquired | Full call number | Barcode | Koha item type |
|---|---|---|---|---|---|---|---|
| School of Mechanical & Manufacturing Engineering (SMME) | School of Mechanical & Manufacturing Engineering (SMME) | E-Books | 02/26/2024 | 610 | SMME-TH-993 | Thesis |