In-Vivo Evaluation Of Silymarin Encapsulated Liposomal Nanoparticles In Chronic Mild Stress (Cms) Model And Depression Induced Liver Disorders / (Record no. 608369)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 03187nam a22001577a 4500 |
| 082 ## - DEWEY DECIMAL CLASSIFICATION NUMBER | |
| Classification number | 610 |
| 100 ## - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Fatima, Misha |
| 245 ## - TITLE STATEMENT | |
| Title | In-Vivo Evaluation Of Silymarin Encapsulated Liposomal Nanoparticles In Chronic Mild Stress (Cms) Model And Depression Induced Liver Disorders / |
| Statement of responsibility, etc. | Misha Fatima |
| 264 ## - PRODUCTION, PUBLICATION, DISTRIBUTION, MANUFACTURE, AND COPYRIGHT NOTICE | |
| Place of production, publication, distribution, manufacture | Islamabad : |
| Name of producer, publisher, distributor, manufacturer | SMME- NUST; |
| Date of production, publication, distribution, manufacture, or copyright notice | 2022. |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 77p. |
| Other physical details | Islamabad : SMME- NUST; Soft Copy |
| Dimensions | 30cm |
| 500 ## - GENERAL NOTE | |
| General note | Depression is categorized as one of the most prevalent psychological disorders that affect personal<br/>wellbeing and social life of individuals. Symptoms vary from anhedonia to suicide commitment.<br/>The molecular mechanism behind is the low concentration of neurotransmitters serotonin,<br/>dopamine and norepinephrine in central nervous system. These are primarily responsible for<br/>regulating and alleviating mood. In the chronic mild stress (CMS) model of depression, silymarin,<br/>a plant-derived polyphenolic flavonoid of Silybum marianum, elicited strong antidepressant-like<br/>action. It increased the levels of monoamines, particularly 5-hydroxytryptamine (5-HT) in the<br/>cortex and dopamine (DA) in the mice hippocampal region and prefrontal cortex. The objective of<br/>the current research was to investigate silymarin's antidepressant potential in CMS-induced<br/>depressive-like behavior in mice and to identify its potential mechanism(s) of action. The mice<br/>were given silymarin and silymarin loaded liposomal nanoparticles (SLNPs) for two weeks after<br/>following CMS protocol for 28 days (4 weeks). Animals were assessed for behavioral alterations,<br/>including exploratory activity in an open field test, behavioral despair in a forced swim test, and<br/>anxiety-like behaviors in an elevated plus maze test. There lies a close relationship between<br/>depression and inflammatory liver diseases. Hence the effect of depression on liver has also been<br/>checked. Silymarin is a commercially available hepatoprotective drug but due to its antioxidant<br/>properties, research has been conducted to evaluate its neuroprotective effect and hence its<br/>prescription as antidepressant drug. However, due to its poor solubility and bioavailability there is<br/>delay in the onset of treatment outcomes in many individuals. Certain side effects and<br/>contraindications are also important regimen opponents. In this study, Silymarin loaded liposomal<br/>nanoparticles (SLNPs) are prepared, characterized, and realized for the depression treatment in<br/>Chronic Mild Stress (CMS) mice model of depression and its treatment efficiency on symptoms<br/>of inflammatory liver diseases in mice as well. It presented face construct and validity response.<br/>As such the SLNPs present improvement in depression measurement parameters as compared to<br/>the simple silymarin. The SLNPs also positively impacted the aggression, anhedonia and rearing<br/>in mice, however simple silymarin treated mice did not show improvement in social and personal<br/>behavior. As such SLNPs compensated for delayed onset of fluoxetine response. |
| 650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | MS Biomedical Sciences (BMS) |
| 700 ## - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Supervisor : Dr. Nosheen Fatima Rana |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="http://10.250.8.41:8080/xmlui/handle/123456789/31458">http://10.250.8.41:8080/xmlui/handle/123456789/31458</a> |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | |
| Koha item type | Thesis |
| Withdrawn status | Permanent Location | Current Location | Shelving location | Date acquired | Full call number | Barcode | Koha item type |
|---|---|---|---|---|---|---|---|
| School of Mechanical & Manufacturing Engineering (SMME) | School of Mechanical & Manufacturing Engineering (SMME) | E-Books | 02/27/2024 | 610 | SMME-TH-796 | Thesis |