Investigation of Silymarin Encapsulated Liposomal Nanoparticles Against Copper Toxicity Associated Liver Dysfunction and Neurobehavioral Abnormalities in Wistar Rats / (Record no. 608370)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 02917nam a22001577a 4500 |
| 082 ## - DEWEY DECIMAL CLASSIFICATION NUMBER | |
| Classification number | 610 |
| 100 ## - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Maryam, Tuba |
| 245 ## - TITLE STATEMENT | |
| Title | Investigation of Silymarin Encapsulated Liposomal Nanoparticles Against Copper Toxicity Associated Liver Dysfunction and Neurobehavioral Abnormalities in Wistar Rats / |
| Statement of responsibility, etc. | Tuba Maryam |
| 264 ## - PRODUCTION, PUBLICATION, DISTRIBUTION, MANUFACTURE, AND COPYRIGHT NOTICE | |
| Place of production, publication, distribution, manufacture | Islamabad : |
| Name of producer, publisher, distributor, manufacturer | SMME- NUST; |
| Date of production, publication, distribution, manufacture, or copyright notice | 2022. |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 69p. |
| Other physical details | Soft Copy |
| Dimensions | 30cm |
| 500 ## - GENERAL NOTE | |
| General note | The fields of nanomedicine and nano delivery systems, in which nanoscale materials are utilized<br/>as diagnostic instruments or to administer therapeutic medicines to precisely targeted areas, are<br/>new but rapidly developing fields. Through a thorough examination of nanoparticle production<br/>and use, nanomedicines and nano-based drug delivery systems improve the effectiveness of both<br/>new and existing treatments. Recent years have seen a surge in interest in the use of<br/>nanoparticulate structures including stimuli-sensitive polymers and liposomes for the treatment<br/>of liver disorders. Wilson disease is characterized by copper accumulation in both the liver and<br/>extrahepatic organs. The liver is particularly vulnerable to chronic copper poisoning because it is<br/>the first organ to absorb copper from the circulation. Copper's toxicity manifests in several ways,<br/>including liver cirrhosis, hemolytic anemia, renal tubule injury, damage to the brain and other<br/>systems. The available therapies aim to lower copper levels by various means. However, a potent<br/>therapeutic drug that can repair the damaged brain and liver tissue is desperately needed.<br/>Milk thistle (Silybum marianum L.), a member of the Carduus marianum family, has been used<br/>for decades to treat liver and gallbladder problems. Medical researchers have shown silymarin<br/>and silibinin to have hepatoprotective, antioxidant, and cytoprotective properties. The<br/>effectiveness of silymarin as a medication for the liver is diminished by its poor water solubility<br/>and low oral bioavailability.<br/>In order to get around these problems, the "thin film hydration method" was used for<br/>synthesizing liposome nanoparticles that are encapsulated with silymarin and may be used to<br/>combat copper toxicity. Polyethylene glycol (PEG) was employed to coat the liposome<br/>nanoparticles to increase their stability and to induce the stealth effect. After the induction of<br/>copper toxicity in rats, various methods such as serological analysis and behavioral tests were<br/>carried out to assess the effectiveness of the different treatment plans. The silymarin liposome<br/>nanoparticles showed improved treatment as compared to silymarin. The combination therapy of<br/>the liposomes along with zinc proved to be a more effective treatment plan than zinc therapy. |
| 650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | MS Biomedical Sciences (BMS |
| 700 ## - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Supervisor : Dr. Nosheen Fatima Rana |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="http://10.250.8.41:8080/xmlui/handle/123456789/31457">http://10.250.8.41:8080/xmlui/handle/123456789/31457</a> |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | |
| Koha item type | Thesis |
| Withdrawn status | Permanent Location | Current Location | Shelving location | Date acquired | Full call number | Barcode | Koha item type |
|---|---|---|---|---|---|---|---|
| School of Mechanical & Manufacturing Engineering (SMME) | School of Mechanical & Manufacturing Engineering (SMME) | E-Books | 02/27/2024 | 610 | SMME-TH-795 | Thesis |