Analyzing The Hepatoprotective Effects Of Silymarin Encapsulated Pegylated Liposomal Nanoparticles And Vitamin D & E For Targeted Nafld Treatment In Wistar Rats / (Record no. 608372)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 02836nam a22001577a 4500 |
| 082 ## - DEWEY DECIMAL CLASSIFICATION NUMBER | |
| Classification number | 610 |
| 100 ## - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Batool, Farhat |
| 245 ## - TITLE STATEMENT | |
| Title | Analyzing The Hepatoprotective Effects Of Silymarin Encapsulated Pegylated Liposomal Nanoparticles And Vitamin D & E For Targeted Nafld Treatment In Wistar Rats / |
| Statement of responsibility, etc. | Farhat Batool |
| 264 ## - PRODUCTION, PUBLICATION, DISTRIBUTION, MANUFACTURE, AND COPYRIGHT NOTICE | |
| Place of production, publication, distribution, manufacture | Islamabad : |
| Name of producer, publisher, distributor, manufacturer | SMME- NUST; |
| Date of production, publication, distribution, manufacture, or copyright notice | 2022. |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 78p. |
| Other physical details | Soft Copy |
| Dimensions | 30cm |
| 500 ## - GENERAL NOTE | |
| General note | Nanotechnology-based therapeutics have recently emerged as an inventive and optimistic<br/>replacement for traditional therapy. Currently, biocompatible materials are used to create<br/>nanoparticles and they have the potential to deliver drugs more precisely, either inactively by<br/>enhancing the drug nanocarriers' physicochemical characteristics or actively by applying<br/>homing technologies tailored to particular tissues or cells that enable disease site targeting<br/>while minimising side effects. Because of their ability to overcome a wide range of<br/>biomedical, biological or biophysical constraints, NPs can be developed as nanoplatforms for<br/>efficient drug delivery.<br/>Silymarin has a diverse set of in vitro and in vivo actions, including antioxidant, antiinflammatory, dose-dependent anti-apoptotic, and cell transporter altering properties. As a<br/>result, it has the potential to be a promising medication in alternative medicine. However,<br/>oral silymarin has a low bioavailability, which restricts its medical applications. But the<br/>bioavailability of silymarin can be increased by using liposomes as drug delivery systems. In<br/>the current study, the silymarin-loaded pegylated liposomal nanoparticle was successfully<br/>created and employed as a treatment for NAFLD. Liposomal NPs can be created as<br/>nanoplatforms for the effective and targeted delivery of drugs due to their ability to pass<br/>through a number of biological, biophysical, and biomedical barriers<br/>To overcome the drawbacks, silymarin encapsulated liposome nanoparticles were synthesized<br/>utilizing DPPE by the ‘thin film hydration method’ and used against liver cirrhosis for the<br/>first time. To enhance the stability, Polyethylene glycol (PEG) was used to enhance stability<br/>and for inducing the stealth effect, by coating the liposomes nanoparticles. Pegylation<br/>enhances the steric repulsion and is hence known a as better stabilizer for different types of<br/>nanoparticles. PEG follows the erosion-controlled release mechanisthe m of drug that resulta<br/>ed in sustained release. Hence, it is noteworthy that encapsulating the silymarin drug within<br/>liposomes and tailoring these liposome nanoparticles by PEG, is a substantial strategy to<br/>combat NAFLD. |
| 650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | MS Biomedical Sciences (BMS) |
| 700 ## - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Supervisor : Dr. Nosheen Fatima Rana |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="http://10.250.8.41:8080/xmlui/handle/123456789/31456">http://10.250.8.41:8080/xmlui/handle/123456789/31456</a> |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | |
| Koha item type | Thesis |
| Withdrawn status | Permanent Location | Current Location | Shelving location | Date acquired | Full call number | Barcode | Koha item type |
|---|---|---|---|---|---|---|---|
| School of Mechanical & Manufacturing Engineering (SMME) | School of Mechanical & Manufacturing Engineering (SMME) | E-Books | 02/27/2024 | 610 | SMME-TH-794 | Thesis |