Saikosaponin B2 modulate oxidative stress in scopolamine induced murine model of Alzheimer’s Disease / (Record no. 608656)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 01566nam a22001577a 4500 |
| 082 ## - DEWEY DECIMAL CLASSIFICATION NUMBER | |
| Classification number | 610 |
| 100 ## - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Malik, Mehreen Nadeem |
| 245 ## - TITLE STATEMENT | |
| Title | Saikosaponin B2 modulate oxidative stress in scopolamine induced murine model of Alzheimer’s Disease / |
| Statement of responsibility, etc. | Mehreen Nadeem Malik |
| 264 ## - PRODUCTION, PUBLICATION, DISTRIBUTION, MANUFACTURE, AND COPYRIGHT NOTICE | |
| Place of production, publication, distribution, manufacture | Islamabad : |
| Name of producer, publisher, distributor, manufacturer | SMME- NUST; |
| Date of production, publication, distribution, manufacture, or copyright notice | 2022. |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 80p. |
| Other physical details | Soft Copy |
| Dimensions | 30cm |
| 500 ## - GENERAL NOTE | |
| General note | One of the initial pathological hallmarks of Alzheimer's disease is cognitive decline and<br/>memory loss by disruption of cholinergic neurons and oxidative brain damage. A<br/>postsynaptic muscarinic receptor blocker, scopolamine impairs cholinergic<br/>transmission and impairs cognition. Here, we observed the physiological processes<br/>underlying Saikosaponin b2's impact on memory deficits in mice that had been given<br/>scopolamine repeatedly. Scopolamine (1 mg/kg) administration for 15 days caused<br/>severe deficits in working and short-term memory in mice, as determined by the<br/>elevated plus maze, Morris water maze, and novel object recognition tests. However,<br/>scopolamine administered mice who were additionally given Saikosaponin b2 did not<br/>experience either deficit. This effect was associated with an increase in antioxidant<br/>enzymes (superoxide dismutase, Glutathione reductase, glutathione s transferase and<br/>catalase), followed by reduction in lipid peroxidation and myeloperoxidase activity. |
| 650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | MS Biomedical Sciences (BMS) |
| 700 ## - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Supervisor : Dr. Adeeb Shehzad |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="http://10.250.8.41:8080/xmlui/handle/123456789/31386">http://10.250.8.41:8080/xmlui/handle/123456789/31386</a> |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | |
| Koha item type | Thesis |
| Withdrawn status | Permanent Location | Current Location | Shelving location | Date acquired | Full call number | Barcode | Koha item type |
|---|---|---|---|---|---|---|---|
| School of Mechanical & Manufacturing Engineering (SMME) | School of Mechanical & Manufacturing Engineering (SMME) | E-Books | 03/11/2024 | 610 | SMME-TH-789 | Thesis |