Characterization of atrial natriuretic peptide (ANP) response in depression-induced mice models / (Record no. 608667)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 02345nam a22001577a 4500 |
| 082 ## - DEWEY DECIMAL CLASSIFICATION NUMBER | |
| Classification number | 610 |
| 100 ## - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Ali, Saman |
| 245 ## - TITLE STATEMENT | |
| Title | Characterization of atrial natriuretic peptide (ANP) response in depression-induced mice models / |
| Statement of responsibility, etc. | Saman Ali |
| 264 ## - PRODUCTION, PUBLICATION, DISTRIBUTION, MANUFACTURE, AND COPYRIGHT NOTICE | |
| Place of production, publication, distribution, manufacture | Islamabad : |
| Name of producer, publisher, distributor, manufacturer | SMME- NUST; |
| Date of production, publication, distribution, manufacture, or copyright notice | 2024. |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 71p. |
| Other physical details | Soft Copy |
| Dimensions | 30cm |
| 500 ## - GENERAL NOTE | |
| General note | Depression is a complex psychological disorder that is also often link to the hormonal<br/>imbalances. Our research delves into the intricate relationship between depression and<br/>atrial Natriuretic Peptide (ANP), considering the multifaceted influences of neurological,<br/>genetic, and environmental factors. With a focus on hormonal imbalances as key<br/>contributors to depression, our investigation explores the potential therapeutic effects of<br/>Levothyroxine (LT4) in the context of ANP. Utilizing an early weaning mouse model<br/>involving maternal separation, we conducted a detailed examination of the anxiolytic<br/>effects of LT4, aiming to evaluate its efficacy in alleviating symptoms associated with<br/>anxiety and depression. Behavioral assessments and histological analyses were employed<br/>to comprehensively evaluate the impact of LT4 on ANP. This study also extends to<br/>molecular investigations using RT-PCR to analyze the distribution and expression of ANP<br/>within the mouse central nervous system, highlighting the cortex region. Our findings<br/>reveal significant differences in brain expression levels of ANP between treated mice and<br/>those exhibiting depressive symptoms. This insight suggests potential therapeutic<br/>applications of ANP for mitigating depression, presenting intriguing avenues for further<br/>research, particularly in the context of depression-induced mouse models through parental<br/>separation. This research contributes to an enriched understanding of the complex factors<br/>influencing depression and proposes interventions that extend beyond conventional<br/>approaches. The integration of behavioral assessments, histological analyses, and<br/>molecular investigations offers a holistic perspective, laying the groundwork for future<br/>exploration in the critical realm of mental health research. |
| 650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | MS Biomedical Sciences (BMS) |
| 700 ## - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Supervisor : Dr. Aneeqa Noor |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="http://10.250.8.41:8080/xmlui/handle/123456789/42576">http://10.250.8.41:8080/xmlui/handle/123456789/42576</a> |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | |
| Koha item type | Thesis |
| Withdrawn status | Permanent Location | Current Location | Shelving location | Date acquired | Full call number | Barcode | Koha item type |
|---|---|---|---|---|---|---|---|
| School of Mechanical & Manufacturing Engineering (SMME) | School of Mechanical & Manufacturing Engineering (SMME) | E-Books | 03/12/2024 | 610 | SMME-TH-998 | Thesis |