Therapeutic Potential of Galantamine for Managing the Complications Associated with Ischemic Stroke / (Record no. 608668)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 02412nam a22001577a 4500 |
| 082 ## - DEWEY DECIMAL CLASSIFICATION NUMBER | |
| Classification number | 610 |
| 100 ## - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Ahsan, Mehwish |
| 245 ## - TITLE STATEMENT | |
| Title | Therapeutic Potential of Galantamine for Managing the Complications Associated with Ischemic Stroke / |
| Statement of responsibility, etc. | Mehwish Ahsan |
| 264 ## - PRODUCTION, PUBLICATION, DISTRIBUTION, MANUFACTURE, AND COPYRIGHT NOTICE | |
| Place of production, publication, distribution, manufacture | Islamabad : |
| Name of producer, publisher, distributor, manufacturer | SMME- NUST; |
| Date of production, publication, distribution, manufacture, or copyright notice | 2024. |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 104p. |
| Other physical details | Soft Copy |
| Dimensions | 30cm |
| 500 ## - GENERAL NOTE | |
| General note | Ischemic stroke remains the leading cause of illness and second leading cause of death<br/>worldwide. Previous research has shown that galantamine has neuroprotective properties,<br/>reducing neuronal death and damage in neurodegenerative conditions and improving cognitive<br/>function in Alzheimer's disease patients. The investigation looked into the possible<br/>mechanisms by which this medication could reduce cell death. Wistar rats were subjected to a<br/>temporary 30-minute occlusion of the right middle cerebral artery (MCA) and given an oral<br/>dose of 5mg/kg for three weeks. After 18 days of surgery, behavioral assessments were carried<br/>out. Galantamine enhanced grip strength, motor function, and muscle strength in rats. Spatial<br/>memory and object recognition examinations revealed cognitive improvements, thus indicating<br/>enhanced cognitive abilities and memory retention. Moreover, rats subjected to galantamine<br/>treatment displayed increased sociability and heightened locomotor activity during social<br/>interaction and open-field assessments. Molecular analysis of galantamine treatment in rats<br/>showed an upregulation of SOD2 expression, suggesting enhanced antioxidant defense, and a<br/>downregulation of TLR4 expression, suggesting a reduction in neuroinflammation, supporting<br/>the anti-inflammatory properties of galantamine. The histological analysis done with H&E<br/>staining of brain tissue revealed enhanced tissue morphology in the galantamine-treated group,<br/>signifying the neuroprotective effects of galantamine. The reduction in neuronal damage,<br/>edema, and inflammatory cell infiltration further supported this observation. The results<br/>demonstrate that galantamine, potentially through the preservation of a functional cholinergic<br/>system, mitigated the impairments caused by stroke in a basic learning and memory test by<br/>decreasing cellular death. |
| 650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | MS Biomedical Sciences (BMS) |
| 700 ## - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Supervisor : Dr. Aneeqa Noor |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="http://10.250.8.41:8080/xmlui/handle/123456789/42579">http://10.250.8.41:8080/xmlui/handle/123456789/42579</a> |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | |
| Koha item type | Thesis |
| Withdrawn status | Permanent Location | Current Location | Shelving location | Date acquired | Full call number | Barcode | Koha item type |
|---|---|---|---|---|---|---|---|
| School of Mechanical & Manufacturing Engineering (SMME) | School of Mechanical & Manufacturing Engineering (SMME) | E-Books | 03/12/2024 | 610 | SMME-TH-999 | Thesis |