Association of Cognitive Impairment with the Presence of Fusobacterium nucleatum in Oral Microbiome of Pakistani Population / (Record no. 608669)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 03013nam a22001577a 4500 |
| 082 ## - DEWEY DECIMAL CLASSIFICATION NUMBER | |
| Classification number | 610 |
| 100 ## - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Adeel, Maha |
| 245 ## - TITLE STATEMENT | |
| Title | Association of Cognitive Impairment with the Presence of Fusobacterium nucleatum in Oral Microbiome of Pakistani Population / |
| Statement of responsibility, etc. | Maha Adeel |
| 264 ## - PRODUCTION, PUBLICATION, DISTRIBUTION, MANUFACTURE, AND COPYRIGHT NOTICE | |
| Place of production, publication, distribution, manufacture | Islamabad : |
| Name of producer, publisher, distributor, manufacturer | SMME- NUST; |
| Date of production, publication, distribution, manufacture, or copyright notice | 2024. |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 135p. |
| Other physical details | Soft Copy |
| Dimensions | 30cm |
| 500 ## - GENERAL NOTE | |
| General note | World Health Organization (WHO) states that the global prevalence of dementia is<br/>estimated to be 55 million, making it a significant public health concern. A person’s daily life<br/>is greatly impacted by dementia, a severe form of cognitive impairment. Cognitive impairment<br/>is the word used to characterize problems with learning, memory loss, concentration issues,<br/>and trouble making decisions. With declining changes in cognitive capacities as people age,<br/>cognitive impairment is another age-related degenerative disorder. Cognitive impairment in<br/>middle-aged and older adults can advance from subjective cognitive impairment (SCI) to mild<br/>cognitive impairment (MCI). Significantly, studies indicate that dental and cognitive health are<br/>correlated. Dysbiosis of the oral microbiome, which shows up as a shift toward excess growth<br/>of pathobiont within the typical microflora and an increase in local inflammation, has a<br/>substantial impact on the onset and progression of periodontitis. Numerous systemic disorders<br/>have been associated with Fusobacterium nucleatum, an infection that greatly grows in<br/>periodontitis. As far as cognitive impairment is concerned, this study is the first to assess the<br/>prevalence of F. nucleatum in the Pakistani population across various age groups. In Pakistan,<br/>no previous study of this kind has been conducted. A comprehensive survey was also carried<br/>out in this investigation to determine the prevalence of F. nucleatum that causes cognitive<br/>impairment. The bacterial load among the cognitively impaired group of participants with<br/>lower MMSE scores was higher as compared to the healthy group of participants. The results<br/>indicate that F. nucleatum may be involved in cognitive alterations. Consequently, the probable<br/>contribution of F. nucleatum provides information about a potential link between cognitive<br/>decline and its prevalence. The present study suggests that the occurrence of bleeding and<br/>redness in those with lower MMSE scores emphasizes the connection between dental health<br/>and cognitive function. Due to significant cognitive loss, poor oral hygiene was more common<br/>in participants with lower MMSE scores. This made it challenging for the cognitively impaired<br/>group of participants to maintain good oral hygiene. Thus, the prevalence of F. nucleatum in<br/>addition to other oral health issues can contribute towards a greater decline in MMSE scores in<br/>the aging population. |
| 650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | MS Biomedical Sciences (BMS) |
| 700 ## - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Supervisor : Dr. Aneeqa Noor |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="http://10.250.8.41:8080/xmlui/handle/123456789/42580">http://10.250.8.41:8080/xmlui/handle/123456789/42580</a> |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | |
| Koha item type | Thesis |
| Withdrawn status | Permanent Location | Current Location | Shelving location | Date acquired | Full call number | Barcode | Koha item type |
|---|---|---|---|---|---|---|---|
| School of Mechanical & Manufacturing Engineering (SMME) | School of Mechanical & Manufacturing Engineering (SMME) | E-Books | 03/12/2024 | 610 | SMME-TH-1000 | Thesis |