Role of Schisandrin-A against Enterococcus faecalis in-vitro studies / (Record no. 608761)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 02694nam a22001577a 4500 |
| 082 ## - DEWEY DECIMAL CLASSIFICATION NUMBER | |
| Classification number | 610 |
| 100 ## - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Bibi, Sabina |
| 245 ## - TITLE STATEMENT | |
| Title | Role of Schisandrin-A against Enterococcus faecalis in-vitro studies / |
| Statement of responsibility, etc. | Sabina Bibi |
| 264 ## - PRODUCTION, PUBLICATION, DISTRIBUTION, MANUFACTURE, AND COPYRIGHT NOTICE | |
| Place of production, publication, distribution, manufacture | Islamabad : |
| Name of producer, publisher, distributor, manufacturer | SMME- NUST; |
| Date of production, publication, distribution, manufacture, or copyright notice | 2024. |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 98p. |
| Other physical details | Islamabad : SMME- NUST; Soft Copy |
| Dimensions | 30cm |
| 500 ## - GENERAL NOTE | |
| General note | This study delves into the investigation of Schisandrin-A's antibacterial efficacy against<br/>Enterococcus faecalis jh2-2, a pathogenic strain associated with escalating concerns of<br/>antibiotic resistance. Recognizing the pressing need for alternative treatments, we<br/>employed a multifaceted approach, including Minimum Inhibitory Concentration (MIC)<br/>testing, DNA extraction, Time-Kill Kinetics assays, and Scanning Electron Microscopy.<br/>Through meticulous MIC testing, concentration-dependent antibacterial effects of<br/>Schisandrin-A were revealed, showcasing its potential as a potent agent against<br/>Enterococcus faecalis. Drug DNA interaction techniques provided insights into the<br/>molecular dynamics of the compound's interaction, unraveling potential structural<br/>changes and binding modes with bacterial DNA. The Time-Kill Kinetics assays further<br/>elucidated the bactericidal activity of Schisandrin-A over varying concentrations and time<br/>intervals. These assays offered a comprehensive understanding of the compound's impact<br/>on bacterial viability, providing valuable data for assessing its therapeutic potential.<br/>Scanning Electron Microscopy unveiled morphological changes induced by SchisandrinA, shedding light on its mechanisms of action at a microscopic level. These findings<br/>collectively contribute to a nuanced comprehension of Schisandrin-A's antibacterial<br/>effects, offering insights into its potential application in combating antibiotic-resistant<br/>strains, particularly Enterococcus faecalis jh2-2. This research holds significant<br/>implications for public health, addressing the challenges posed by antibiotic-resistant<br/>bacterial strains. The identified antibacterial properties of Schisandrin-A provide a<br/>foundation for further exploration and development of alternative therapeutic strategies,<br/>aiming to mitigate the risks associated with conventional antibiotic treatments. By<br/>vii<br/>unraveling the complex interplay between Schisandrin-A and Enterococcus faecalis jh2-<br/>2, this study contributes to the ongoing efforts to confront the global issue of antibiotic<br/>resistance and enhance the arsenal of effective antibacterial agents. |
| 650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | MS Biomedical Sciences (BMS) |
| 700 ## - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Supervisor : Dr. Nosheen Fatima Rana |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="http://10.250.8.41:8080/xmlui/handle/123456789/42790">http://10.250.8.41:8080/xmlui/handle/123456789/42790</a> |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | |
| Koha item type | Thesis |
| Withdrawn status | Permanent Location | Current Location | Shelving location | Date acquired | Full call number | Barcode | Koha item type |
|---|---|---|---|---|---|---|---|
| School of Mechanical & Manufacturing Engineering (SMME) | School of Mechanical & Manufacturing Engineering (SMME) | E-Books | 04/01/2024 | 610 | SMME-TH-1005 | Thesis |