Enhancing the Functionality of Polyethersulfone Hemodialysis Membranes Using Water-Soluble Hydrophilic Additives / (Record no. 608763)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 02526nam a22001577a 4500 |
| 082 ## - DEWEY DECIMAL CLASSIFICATION NUMBER | |
| Classification number | 610 |
| 100 ## - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Manzoor, Saira |
| 245 ## - TITLE STATEMENT | |
| Title | Enhancing the Functionality of Polyethersulfone Hemodialysis Membranes Using Water-Soluble Hydrophilic Additives / |
| Statement of responsibility, etc. | Saira Manzoor |
| 264 ## - PRODUCTION, PUBLICATION, DISTRIBUTION, MANUFACTURE, AND COPYRIGHT NOTICE | |
| Place of production, publication, distribution, manufacture | Islamabad : |
| Name of producer, publisher, distributor, manufacturer | SMME- NUST; |
| Date of production, publication, distribution, manufacture, or copyright notice | 2024. |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 84p. |
| Other physical details | Soft Copy |
| Dimensions | 30cm |
| 500 ## - GENERAL NOTE | |
| General note | The kidneys play a critical part in maintaining internal equilibrium of the body. However,<br/>renal diseases present a significant public health concern, affecting millions of individuals<br/>worldwide. Polyethersulfone (PES) based hemodialysis membranes can provide a lifesustaining treatment procedure for patients suffering from renal disease. Nevertheless, the<br/>intrinsic hydrophobic nature of PES contributes to an inefficiency of uremic toxin<br/>clearance and a compromised hemocompatibility. This work evaluates the individual and<br/>combined effects of two water-soluble hydrophilic additives, polyethylene glycol (PEG)<br/>and polyvinylpyrrolidone (PVP), on the functionality of polyethersulfone (PES)<br/>membranes. The membranes were synthesized by the non-solvent phase inversion method<br/>by using NMP as the solvent. The fabricated membranes were characterized by using<br/>Scanning Electron Microscopy, ATR-FTIR, tensile testing, porosity, and contact angle<br/>analysis. The SEM images demonstrated the successful fabrication of the membranes. Each<br/>membrane possessed a thin skin layer and an asymmetric porous framework. As a result of<br/>the synergistic effect, the membrane with dual WSP—2.5% PVP and 2.5% PEG—<br/>performed better than membranes with a single water-soluble hydrophilic additive. The<br/>membranes comprising the two additives had excellent hydrophilicity, increased porosity,<br/>and a high-water retention capacity. Moreover, they showed a urea clearance of 77.3%, a<br/>pure water flux of 96 L/m²/h, and an outstanding BSA rejection of 99.10%. RSM modelling<br/>was employed to determine the urea clearance that verified the ideal conditions for urea<br/>removal were concentrations of 1200 mg/L and 0.6 MPa. The effectiveness of membrane<br/>containing dual WSP for hemodialysis was further demonstrated by hemocompatibility<br/>xv<br/>tests, which provided promising results (APTT 32s, PT 14s, plasma recalcification time<br/>205.5s, and hemolysis rate 1.32%). |
| 650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | MS Biomedical Sciences (BMS) |
| 700 ## - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Supervisor : Dr. Muhammad Nabeel Anwar |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="http://10.250.8.41:8080/xmlui/handle/123456789/42792">http://10.250.8.41:8080/xmlui/handle/123456789/42792</a> |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | |
| Koha item type | Thesis |
| Withdrawn status | Permanent Location | Current Location | Shelving location | Date acquired | Full call number | Barcode | Koha item type |
|---|---|---|---|---|---|---|---|
| School of Mechanical & Manufacturing Engineering (SMME) | School of Mechanical & Manufacturing Engineering (SMME) | E-Books | 04/01/2024 | 610 | SMME-TH-1007 | Thesis |