| 000 -LEADER |
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| fixed length control field |
03475nam a22001577a 4500 |
| 082 ## - DEWEY DECIMAL CLASSIFICATION NUMBER |
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| Classification number |
621 |
| 100 ## - MAIN ENTRY--PERSONAL NAME |
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| Personal name |
Abid, Zeeshan |
| 245 ## - TITLE STATEMENT |
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| Title |
Numerical Analysis on 3D Microfluidic Paper Based Analytical Device / |
| Statement of responsibility, etc. |
Zeeshan Abid |
| 264 ## - PRODUCTION, PUBLICATION, DISTRIBUTION, MANUFACTURE, AND COPYRIGHT NOTICE |
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| Place of production, publication, distribution, manufacture |
Islamabad : |
| Name of producer, publisher, distributor, manufacturer |
SMME- NUST; |
| Date of production, publication, distribution, manufacture, or copyright notice |
2022. |
| 300 ## - PHYSICAL DESCRIPTION |
|---|
| Extent |
56p. |
| Other physical details |
Soft Copy |
| Dimensions |
30cm |
| 500 ## - GENERAL NOTE |
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| General note |
Paper-based microfluidics are microfluidic devices that consist of a series of hydrophilic<br/>cellulose or nitrocellulose fibers that transport fluid from an inlet through the porous medium to<br/>a desired outlet or region of the device, by means of capillary action. Paper is abundant and<br/>compatible with many chemical/biochemical/medical applications, it is easy to use, disposable,<br/>equipment free, and its high surface area improves detection limits for colorimetric method, its<br/>ability to store reagents in active form within the fiber network. It provides a novel system for<br/>fluid handling and fluid analysis for a variety of applications including health diagnostics,<br/>environmental monitoring as well as food testing. It has been used from spot tests for metals and<br/>paper chromatography to lateral flow immunoassays and later now as multilayered (µPADs).<br/>Different technologies has been adopted in past for fabrication of (µPADs). The fundamental<br/>principle underlying these fabrication techniques is to pattern hydrophilic-hydrophobic contrast<br/>on a sheet of paper in order to create micron-scale (i.e., hundreds to thousands of micrometers)<br/>capillary channels on paper. Their widespread adoption has been limited by slow flow rates of<br/>fluid passing through it, shelf life of enzyme/reagent stored on paper, coffee ring effect in which<br/>there is non-uniform distribution of reagent due to hydrophobic boundary, theoretical modeling<br/>which accurately depicts behavior of fluid flow through multilayered µPADs considering all<br/>design parameters, non-homogenous paper causes anisotropic properties. In counter to that in<br/>this present work, numerical analysis of impact of various design parameters on the performance<br/>of single and multilayered paper based microfluidic analytical devices (µPADs) is performed, in<br/>order to find effect of different design parameters on velocity of fluid e.g. porosity, permeability,<br/>capillary angle, gap height, surface tension, dynamic viscosity, paper thickness, paper width etc.<br/>Based on the results of numerical analysis, it is concluded that permeability, gap height,<br/>interfacial tension, paper thickness are directly proportional with the velocity of fluid and the<br/>remaining design parameters dynamic viscosity, capillary angle are inversely proportional with<br/>the velocity of fluid, porosity doesn’t affect velocity value. Whatman filter paper grade 4 is<br/>recommended for single layered and multilayered microPADs, because velocity of fluid is found<br/>to be 1.3 mm/s in case of single layered microPADs. Maximum gap height that is beneficial for<br/>velocity enhancement in multilayered microPADs is 400 µm. Optimum value of paper width is<br/>found to be 0.02m for enhanced velocity. Based on these findings one can manufacture paper<br/>material of certain desired properties to get favorable results and can also fabricate multilayered<br/>microPADs while keeping gap height behavior under consideration. |
| 650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name entry element |
MS Mechanical Engineering |
| 700 ## - ADDED ENTRY--PERSONAL NAME |
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| Personal name |
Supervisor : Dr. Zaib Ali |
| 856 ## - ELECTRONIC LOCATION AND ACCESS |
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| Uniform Resource Identifier |
<a href="http://10.250.8.41:8080/xmlui/handle/123456789/30607">http://10.250.8.41:8080/xmlui/handle/123456789/30607</a> |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) |
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| Source of classification or shelving scheme |
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| Koha item type |
Thesis |
