Metal Nanoparticles Enhances Sorafenib Activity against Cancerous Cell Lines / (Record no. 610779)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 02647nam a22001577a 4500 |
| 082 ## - DEWEY DECIMAL CLASSIFICATION NUMBER | |
| Classification number | 610 |
| 100 ## - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Jamil, Muhammad Ammad |
| 245 ## - TITLE STATEMENT | |
| Title | Metal Nanoparticles Enhances Sorafenib Activity against Cancerous Cell Lines / |
| Statement of responsibility, etc. | Muhammad Ammad Jamil |
| 264 ## - PRODUCTION, PUBLICATION, DISTRIBUTION, MANUFACTURE, AND COPYRIGHT NOTICE | |
| Place of production, publication, distribution, manufacture | Islamabad : |
| Name of producer, publisher, distributor, manufacturer | SMME- NUST; |
| Date of production, publication, distribution, manufacture, or copyright notice | 2024. |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 108p. |
| Other physical details | Soft Copy |
| Dimensions | 30cm |
| 500 ## - GENERAL NOTE | |
| General note | Globally, cancer prevalence is increasing rapidly, requiring urgent development of effective<br/>therapeutics strategies. Cancer is characterized by uncontrolled cell growth and is categorized into<br/>various stages and types, each with different epidemiology. Cancer cell lines are derived from<br/>many tumor types, then cultured in vitro, and are essential for studying cancer genetic and drug<br/>testing. Sorafenib is a multi-kinase inhibitor drug, widely used in treatment of hepatocellular<br/>carcinoma and renal cell carcinoma, but has limitations such as low bioavailability and solubility.<br/>This study deals with the use of bacopa monnieri for the synthesis of copper formulated and zinc<br/>formulated nano-coated drugs; and investigates their effect of on cancer cell line (MCF-7). Both<br/>nano-coated drugs were characterized by various techniques; UV-Vis spectrometry confirmed the<br/>drug absorbance at 262nm and 263nm, Fourier transform infrared spectroscopy (FTIR) confirmed<br/>the presence of interaction between the sorafenib drug and nanoparticles, X-ray diffraction (XRD)<br/>confirmed their crystallinity nature, Scanning electron microscopy (SEM) revealed that copper<br/>formulated nano-coated drug was stable with good coating and surface morphology and zinc<br/>formulated nano-coated drug was less stable due to irregular shape morphology, Dynamic light<br/>scattering (DSL) confirmed that copper formulated nano-coated drug size ranged from 12nm to<br/>13nm and zinc formulated nano-coated drug size ranged from 9nm to 10nm, Zeta potential<br/>confirmed that copper formulated nano-coated drug was stable (fit values ranged between (-21mV ̶<br/>-18mV)) and zinc formulated nano-coated drug was slightly less stable (fit values ranges -7.12mV ̶<br/>+12.35mV). MTT assay showed that copper formulated nano-coated drug has the cell viability of<br/>64.8% with IC50 value of 4.599µM and zinc formulated nano-coated drug has the cell viability of<br/>68.5% with IC50 value of 34.50µM. Both nano-coated drugs exhibited less cell viability than the<br/>actual drug and are stable, thus, making them suitable for the cancer treatment. |
| 650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | MS Biomedical Sciences (BMS) |
| 700 ## - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Supervisor : Dr. Adeeb Shehzad |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="http://10.250.8.41:8080/xmlui/handle/123456789/45204">http://10.250.8.41:8080/xmlui/handle/123456789/45204</a> |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | |
| Koha item type | Thesis |
| Withdrawn status | Permanent Location | Current Location | Shelving location | Date acquired | Full call number | Barcode | Koha item type |
|---|---|---|---|---|---|---|---|
| School of Mechanical & Manufacturing Engineering (SMME) | School of Mechanical & Manufacturing Engineering (SMME) | E-Books | 08/06/2024 | 610 | SMME-TH-1036 | Thesis |