Development Of Novel Diagnostic Angiographic Catheter, Evaluation of Its Efficacy, Precision, And Ease of Application / (Record no. 610791)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 03617nam a22001577a 4500 |
| 082 ## - DEWEY DECIMAL CLASSIFICATION NUMBER | |
| Classification number | 610. |
| 100 ## - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Inam, Hafsa |
| 245 ## - TITLE STATEMENT | |
| Title | Development Of Novel Diagnostic Angiographic Catheter, Evaluation of Its Efficacy, Precision, And Ease of Application / |
| Statement of responsibility, etc. | Hafsa Inam |
| 264 ## - PRODUCTION, PUBLICATION, DISTRIBUTION, MANUFACTURE, AND COPYRIGHT NOTICE | |
| Place of production, publication, distribution, manufacture | Islamabad : |
| Name of producer, publisher, distributor, manufacturer | SMME- NUST; |
| Date of production, publication, distribution, manufacture, or copyright notice | 2023. |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 220p. |
| Other physical details | Soft Copy |
| Dimensions | 30cm. |
| 500 ## - GENERAL NOTE | |
| General note | Cardiovascular diseases are a leading cause of death globally, accounting for approximately onethird of all deaths. The prevalence of coronary disease continues to rise, resulting in increased<br/>mortality rates and escalating healthcare costs. The gold standard for diagnosing coronary<br/>blockages and recommending therapeutic interventions is angiography. Currently, braided<br/>reinforced shafts are the most common construction material for catheters used in angiographic<br/>procedures. However, recent research has focused on the development of laser-cut reinforced<br/>shaft catheters. The aim of this study was to assess the potential usage of laser-cut reinforced<br/>shaft-based angiographic catheters for coronary angiographic procedures by analyzing their<br/>design, performance, and behaviour.<br/>The commercially available state-of-the-art angiographic catheters comprise of braidedreinforced shafts, while the laser-cut reinforced shaft technique has never been used to develop<br/>angiographic catheters despite its potential to reduce the wall thickness and consequently the<br/>profile of the catheters without compromising pushability and flexibility. Therefore, the<br/>objective of this study was twofold: (I) designing and manufacturing a laser-cut metallic<br/>reinforced shaft in a novel way and (II) configuring this novel laser-cut metallic shaft as a lasercut reinforced angiography catheter to improve the existing state-of-the-art (braided catheter) by<br/>reducing profile (wall-thickness), enhancing flow rate, flexural and tensile strength, and<br/>decreasing pushability force required. The developed laser-cut angiographic catheter (having an<br/>outer diameter of 2.00 mm) has a wall thickness of 0.2 mm which is approximately 33% less<br/>than that of the commercially available braided catheters (having a wall thickness of 0.3mm).<br/>Furthermore, the pushability force analysis results prove that laser-cut reinforced shaft catheter<br/>exerts a minimal resistive force (625g) which is approximately 1/3rd times less than that of the<br/>braided catheter. Needless to mention that the novel Laser-cut catheter exhibits 2x more tensile<br/>strength than the commercially available braided catheter. The fabrication route employed in this<br/>study also increased the catheter's hydrophilicity (contact angle of 71.3°); as a result, an<br/>additional hydrophilic coating is not required. The outcome of the comparative analysis, based<br/>on the results obtained from the manufacturing route and bench testing, clearly shows that the<br/>laser cutting method is an effective and rapid way of producing flexible, lower-profile reinforced<br/>shaft. It is also established that the use of this method to produce flexible lower profile reinforced<br/>shaft will overcome the problem of compromised radial strength during a diagnostic procedure<br/>xxvii<br/>and would help maintain continuous ovality throughout. Therefore, the developed laser-cut<br/>reinforced catheter may potentially be used as the next state-of-the-art angiographic catheter after<br/>further in vivo and clinical testing. |
| 650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | PhD Biomedical Sciences |
| 700 ## - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Supervisor : Dr. Murtaza Najabat Ali |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="http://10.250.8.41:8080/xmlui/handle/123456789/42483">http://10.250.8.41:8080/xmlui/handle/123456789/42483</a> |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | |
| Koha item type | Thesis |
| Withdrawn status | Permanent Location | Current Location | Shelving location | Date acquired | Full call number | Barcode | Koha item type |
|---|---|---|---|---|---|---|---|
| School of Mechanical & Manufacturing Engineering (SMME) | School of Mechanical & Manufacturing Engineering (SMME) | E-Books | 08/06/2024 | 610. | SMME-Phd-28 | Thesis |