pH-Responsive Aloe Vera Hydrogels Loaded with Imatinib for Targeting Drug Resistance in Cancer / (Record no. 611346)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 02296nam a22001697a 4500 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | NUST |
| 082 ## - DEWEY DECIMAL CLASSIFICATION NUMBER | |
| Classification number | 610 |
| 100 ## - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Hasan Khan ,Aroob |
| 245 ## - TITLE STATEMENT | |
| Title | pH-Responsive Aloe Vera Hydrogels Loaded with Imatinib for Targeting Drug Resistance in Cancer / |
| Statement of responsibility, etc. | Aroob Hasan Khan |
| 264 ## - PRODUCTION, PUBLICATION, DISTRIBUTION, MANUFACTURE, AND COPYRIGHT NOTICE | |
| Place of production, publication, distribution, manufacture | Islamabad, |
| Name of producer, publisher, distributor, manufacturer | SMME-NUST ; |
| Date of production, publication, distribution, manufacture, or copyright notice | 2024. |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 77p. ; |
| Other physical details | softcopy |
| Dimensions | 30cm. |
| 500 ## - GENERAL NOTE | |
| General note | Cancer and its reoccurrence have become a major health problem affecting the<br/>quality of life for millions of individuals every year. The currently available strategies,<br/>radiotherapy, and chemotherapy have non-specific targets, lower solubility, and severe<br/>side effects. Hydrogels are crosslinked polymeric networks with higher swelling<br/>properties, degradation, biocompatibility, and flexibility which can be manipulated based<br/>on the desired application. Incorporating AV can elevate the antioxidant, and anticancer<br/>properties of the hydrogel based drug delivery system (DDS) also warranting enhanced<br/>swelling, drug release, and environmental degradability of the system. Acrylic acid (AA)<br/>induces pH-responsive properties in the hydrogels. The PVA/SA and PVA/SA/AV<br/>hydrogels were synthesized with a pH responsive behavior and investigated at different<br/>pH conditions. The unloaded and loaded PVA/SA and PVA/SA/AV hydrogels with<br/>imatinib (IM) were characterized for their structural morphology, physiochemical<br/>characteristics, and antioxidant and anticancer activity. The IM loaded PVA/SA/AV<br/>hydrogels showed increased pore size in SEM micrographs, enhanced swelling abilities<br/>up to 400%, 100% degradation, 56% encapsulation efficiency, and drug release profiles<br/>of up to 94% in 24 h, compared to PVA/SA hydrogels loaded with IM. Dpph radical<br/>scavenging activity was also observed to be enhanced in PVA/SA/AV hydrogels. Finally,<br/>the cell viability analysis in resistant MCF-7 breast cancer cell lines exhibited 41% cell<br/>viability of the PVA/SA/AV hydrogels loaded with IM implying a promising potential of<br/>AV to be incorporated in a hydrogel based drug delivery system for targeting drug<br/>resistance in cancer. |
| 650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | MS Biomedical Sciences (BMS) |
| 700 ## - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Supervisor: Dr. Adeeb Shehzad |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="http://10.250.8.41:8080/xmlui/handle/123456789/45792">http://10.250.8.41:8080/xmlui/handle/123456789/45792</a> |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | |
| Koha item type | Thesis |
| Withdrawn status | Permanent Location | Current Location | Shelving location | Date acquired | Full call number | Barcode | Koha item type |
|---|---|---|---|---|---|---|---|
| School of Mechanical & Manufacturing Engineering (SMME) | School of Mechanical & Manufacturing Engineering (SMME) | E-Books | 09/03/2024 | 610 | SMME-TH-1052 | Thesis |