Saikosaponin B2 Protects Against LPS Induced Inflammation In Neuronal Cell Lines / (Record no. 611381)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 01388nam a22001697a 4500 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | NUST |
| 082 ## - DEWEY DECIMAL CLASSIFICATION NUMBER | |
| Classification number | 610 |
| 100 ## - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Sajjad ,Aleena |
| 245 ## - TITLE STATEMENT | |
| Title | Saikosaponin B2 Protects Against LPS Induced Inflammation In Neuronal Cell Lines / |
| Statement of responsibility, etc. | Aleena Sajjad |
| 264 ## - PRODUCTION, PUBLICATION, DISTRIBUTION, MANUFACTURE, AND COPYRIGHT NOTICE | |
| Place of production, publication, distribution, manufacture | Islamabad : |
| Name of producer, publisher, distributor, manufacturer | SMME- NUST; |
| Date of production, publication, distribution, manufacture, or copyright notice | 2024. |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 76p. ; |
| Other physical details | Soft Copy |
| Dimensions | 30cm. |
| 500 ## - GENERAL NOTE | |
| General note | This study explores the protective effects of Saikosaponin B2, a triterpenoid extracted from the roots of Radix bupleurum against lipopolysaccharide-induced inflammation, a common model for studying neurodegenerative diseases. LPS induces strong immune reactions, activating pro-inflammatory cytokines, increases ROS generation, ultimately leading to neuronal damage and loss. We theorized that Saikosaponin B2 holds an anti-inflammatory and anti-oxidant profile capable of mitigating LPS-induced effects. An in-vitro model was used to determine the extract’s effectiveness in reducing inflammatory gene expression, ROS generation and activation of injury mechanisms. Our results show that Saikosaponin B2 reduces LPS-induced inflammation, signifying its possible utilization as a therapeutic agent against neurodegenerative diseases. |
| 650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | MS Biomedical Sciences (BMS) |
| 700 ## - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Supervisor: Dr. Adeeb Shehzad |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href=" http://10.250.8.41:8080/xmlui/handle/123456789/46178"> http://10.250.8.41:8080/xmlui/handle/123456789/46178</a> |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | |
| Koha item type | Thesis |
| Withdrawn status | Permanent Location | Current Location | Shelving location | Date acquired | Full call number | Barcode | Koha item type |
|---|---|---|---|---|---|---|---|
| School of Mechanical & Manufacturing Engineering (SMME) | School of Mechanical & Manufacturing Engineering (SMME) | E-Books | 09/04/2024 | 610 | SMME-TH-1062 | Thesis |