Therapeutic Effects of Light Flicker Stimulation in a Mouse Model of Depression - A Comparative Study / (Record no. 615167)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 02488nam a22001577a 4500 |
| 082 ## - DEWEY DECIMAL CLASSIFICATION NUMBER | |
| Classification number | 610 |
| 100 ## - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Hyder, Azan |
| 245 ## - TITLE STATEMENT | |
| Title | Therapeutic Effects of Light Flicker Stimulation in a Mouse Model of Depression - A Comparative Study / |
| Statement of responsibility, etc. | Azan Hyder |
| 264 ## - PRODUCTION, PUBLICATION, DISTRIBUTION, MANUFACTURE, AND COPYRIGHT NOTICE | |
| Place of production, publication, distribution, manufacture | Islamabad : |
| Name of producer, publisher, distributor, manufacturer | SMME- NUST; |
| Date of production, publication, distribution, manufacture, or copyright notice | 2025. |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 80p. |
| Other physical details | Soft Copy |
| Dimensions | 30cm |
| 500 ## - GENERAL NOTE | |
| General note | Depression is a common neuropsychiatric condition, characterized by behavioral deficiencies,<br/>mood swings, and cognitive impairments. Although fluoxetine is still a commonly prescribed<br/>antidepressant, its drawbacks, including systemic side effects and delayed therapeutic results,<br/>make it necessary to look at alternative treatments. Using a chronic restraint stress mouse model,<br/>this study examines the effectiveness of 40 Hz light flicker therapy as a novel, non-invasive<br/>neuromodulatory treatment for depression by directly contrasting it with fluoxetine treatment.<br/>Behavioral tests such as the Light-Dark Box, Forced Swim, and Sucrose Preference tests showed<br/>that 40 Hz light stimulation dramatically reduced depressive-like behaviors, frequently<br/>outperforming the effects of fluoxetine. Histopathological examinations showed that parvalbuminexpressing interneurons, which are necessary for gamma oscillatory activity and inhibitory<br/>circuitry, had been protected in the prefrontal cortex (PFC) and hippocampal regions. Increased<br/>expression of brain-derived neurotrophic factor (BDNF) and parvalbumin (PV) was further<br/>validated by molecular experiments, suggesting improved interneuron integrity and<br/>neuroplasticity. These results demonstrate that 40 Hz light flicker therapy facilitates the functional<br/>restoration of brain regions damaged in depression, pointing to distinct mechanisms from those of<br/>traditional medication. Subsequent research endeavors ought to concentrate on refining<br/>stimulation parameters, evaluating long-term safety and effectiveness, and clarifying<br/>electrophysiological mechanisms via supplementary imaging and neurophysiological studies.<br/>Promising translational potential is indicated by ongoing clinical investigations. To conclude, 40<br/>Hz light flicker therapy might prove to be a useful supplement or substitute therapy, providing a<br/>customized, side-effect-free choice for managing depression. |
| 650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | MS Biomedical Sciences (BMS) |
| 700 ## - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Supervisor : Dr. Aneeqa Noor |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="http://10.250.8.41:8080/xmlui/handle/123456789/55408">http://10.250.8.41:8080/xmlui/handle/123456789/55408</a> |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | |
| Koha item type | Thesis |
| Withdrawn status | Permanent Location | Current Location | Shelving location | Date acquired | Full call number | Barcode | Koha item type |
|---|---|---|---|---|---|---|---|
| School of Mechanical & Manufacturing Engineering (SMME) | School of Mechanical & Manufacturing Engineering (SMME) | E-Books | 10/14/2025 | 610 | SMME-TH-1185 | Thesis |