| 000 -LEADER |
|---|
| fixed length control field |
02283nam a22001577a 4500 |
| 082 ## - DEWEY DECIMAL CLASSIFICATION NUMBER |
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| Classification number |
610 |
| 100 ## - MAIN ENTRY--PERSONAL NAME |
|---|
| Personal name |
Kayani, Hooreen |
| 245 ## - TITLE STATEMENT |
|---|
| Title |
Evaluating the Synergistic Role of Insulin and Photobiomodulation in alleviating Diabetic Neuropathy and Cognitive Impairment / |
| Statement of responsibility, etc. |
Hooreen Kayani |
| 264 ## - PRODUCTION, PUBLICATION, DISTRIBUTION, MANUFACTURE, AND COPYRIGHT NOTICE |
|---|
| Place of production, publication, distribution, manufacture |
Islamabad : |
| Name of producer, publisher, distributor, manufacturer |
SMME- NUST; |
| Date of production, publication, distribution, manufacture, or copyright notice |
2025. |
| 300 ## - PHYSICAL DESCRIPTION |
|---|
| Extent |
88p. |
| Other physical details |
Soft Copy |
| Dimensions |
30cm |
| 500 ## - GENERAL NOTE |
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| General note |
Diabetic neuropathy and cognitive impairment are debilitating complications of diabetes, yet<br/>effective multi-targeted therapies remain limited. This study investigated the synergistic effects<br/>of Insulin and Photobiomodulation (PBM) in a streptozotocin (STZ) induced diabetic mouse<br/>model. Mice were divided into five groups: healthy control, diseased, PBM-treated, Insulintreated, and PBM + Insulin-treated, and received treatments for seven days. Functional<br/>outcomes were assessed through behavioural and biochemical analyses, while<br/>histopathological and molecular evaluations examined tissue integrity and the expression of<br/>neuroprotective markers, including Brain-derived Neurotrophic Factor (BDNF) and Myelin<br/>Protein Zero (MPZ), with β-actin as a reference. The combination of PBM and Insulin<br/>produced the most pronounced improvements, demonstrating enhanced cognitive performance,<br/>reduced neuropathic pain, and preservation of neuronal structure, peripheral nerve integrity,<br/>and multi-organ morphology, including the brain, sciatic nerve, heart, liver, kidney, and lungs.<br/>PBM or Insulin alone provided partial protection, with moderate amelioration of functional<br/>deficits and tissue pathology. Mechanistically, combination therapy upregulated BDNF and<br/>MPZ expression, suggesting a molecular basis for enhanced neuroprotection and<br/>remyelination. These findings highlight the potential of PBM combined with Insulin as a<br/>synergistic intervention to mitigate diabetes-induced neuropathy and cognitive decline.<br/>Incorporating such multi-modal strategies may offer a promising avenue for managing<br/>diabetes-related multi-organ complications and improving overall outcomes in diabetic<br/>patients. |
| 650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM |
|---|
| Topical term or geographic name entry element |
MS Biomedical Sciences (BMS) |
| 700 ## - ADDED ENTRY--PERSONAL NAME |
|---|
| Personal name |
Supervisor : Dr. Aneeqa Noor |
| 856 ## - ELECTRONIC LOCATION AND ACCESS |
|---|
| Uniform Resource Identifier |
<a href="http://10.250.8.41:8080/xmlui/handle/123456789/55406">http://10.250.8.41:8080/xmlui/handle/123456789/55406</a> |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) |
|---|
| Source of classification or shelving scheme |
|
| Koha item type |
Thesis |
