Psoriasis & Neuroinflammation: Exploring Cytokine Release in Barrier and Metabolic Organs / (Record no. 616895)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 03075nam a22001577a 4500 |
| 082 ## - DEWEY DECIMAL CLASSIFICATION NUMBER | |
| Classification number | 610 |
| 100 ## - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Perveen, Anita |
| 245 ## - TITLE STATEMENT | |
| Title | Psoriasis & Neuroinflammation: Exploring Cytokine Release in Barrier and Metabolic Organs / |
| 264 ## - PRODUCTION, PUBLICATION, DISTRIBUTION, MANUFACTURE, AND COPYRIGHT NOTICE | |
| Place of production, publication, distribution, manufacture | Islamabad : |
| Name of producer, publisher, distributor, manufacturer | SMME- NUST; |
| Date of production, publication, distribution, manufacture, or copyright notice | 2026. |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 99p. |
| Other physical details | Islamabad : SMME- NUST; Soft Copy |
| Dimensions | 30cm |
| 500 ## - GENERAL NOTE | |
| General note | Psoriasis is a chronic systemic inflammatory disease with its effects beyond skin. One<br/>major comorbidity reported to be highly prevalent in psoriatic patients is cognitive<br/>impairment. Moreover, overexpression of pro-inflammatory cytokines plays a central role<br/>in development and progression of psoriasis and neuroinflammation. This study aims to<br/>explore the role of inflammatory cytokines in neurodegeneration and disease progression<br/>in psoriatic patients. Furthermore, it assesses the therapeutic effect of curcumin-chamomile<br/>based plant extract loaded onto PVA nanoparticles via wet lab and bioinformatics tools.<br/>Curcumin and Chamomile Plant extract-based drug was designed and loaded with Nanoparticles to use as treatment. The drug was tested on various parameters to check its toxicity<br/>and reactivity before using in-vivo. Psoriatic animal model was designed by imiquimod<br/>(IMQ) application on male BALB/c mice. The complete In-Vivo study from disease<br/>induction to treatment followed by collection of cortex, hippocampus, Eyes, Skin and Liver<br/>was done which were later used for gene expression analysis. Protein hallmarks of<br/>neurodegeneration; α-Syn, and inflammatory cytokines like IL‐1β, TNF‐α, PEBP-1 and<br/>HSP-90AB1 were measured at transcriptional level in cortex, hippocampus, Eyes, Skin<br/>and Liver. Disease induction using IMQ resulted in excessive production of keratinocytes.<br/>Pro-inflammatory cytokines were over-expressed whereas α-Syn showed a moderate<br/>increase in hippocampus, eyes, cortex, liver and skin. Both treatment groups showed a<br/>significant decline in α-Syn and normalization and downregulation of pro-inflammatory<br/>cytokines. Molecular docking revealed potential interactions between proteins and<br/>cytokines, and proteins and phytochemicals exhibiting potential roles in alleviating the<br/>disease pathology. Pathway enrichment analysis was carried out to understand the<br/>underlying mechanisms involved in disease progression and roles of these proteins. The<br/>increased expression of inflammatory markers causes neuroinflammation and contribute to<br/>depression and cognitive impairment, which can be reversed using the novel designed drug.<br/>In psoriatic conditions, elevated levels of inflammatory cytokines cause chronic<br/>inflammation, which trigger neuroinflammatory transcription factors. The Curcuminchamomile based novel drug encapsulated with nanoparticles comes as a new promising<br/>approach to cure neurodegenerative diseases, and the comorbidities arising from psoriasis. |
| 650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | MS Biomedical Sciences (BMS) |
| 700 ## - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Supervisor : Dr. Saima Zafar |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="http://10.250.8.41:8080/xmlui/handle/123456789/57525">http://10.250.8.41:8080/xmlui/handle/123456789/57525</a> |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | |
| Koha item type | Thesis |
| Withdrawn status | Permanent Location | Current Location | Shelving location | Date acquired | Full call number | Barcode | Koha item type |
|---|---|---|---|---|---|---|---|
| School of Mechanical & Manufacturing Engineering (SMME) | School of Mechanical & Manufacturing Engineering (SMME) | E-Books | 04/08/2026 | 610 | SMME-TH-1211 | Thesis |