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Breast cancer is the most common cancer among women even though numerous
treatment options for breast cancer have been documented. Panobinostat, A histone
deacetylase inhibitor, modifies gene expression through epigenetic pathways and
prevents protein breakdown. The focus of this study is to enhance drug distribution to the
tumor site and boost the efficiency of Panobinostat by using silver nanoparticles as
controlled drug delivery system. Here we report the green synthesis of silver
nanoparticles by using Rhazya stricta extract, as a nanocarriers for drug delivery. These
drugs loaded nanoparticles were characterized by UV-Vis spectroscopy, XRD, FTIR,
SEM, and EDX techniques. The overall findings demonstrated that AgNPs synthesized
through Rhazya stricta has the high potential for sustained release of Panobinostat for
cancer therapy. As the successfully synthesized Panobinostat-AgNPs were stable and
exhibited increased in vitro anticancer activity compared with free Panobinostat, our data
demonstrate that the combination of AgNPs with Panobinostat improves the drug's longterm viability, effectiveness, and active targeting as a potential targeted therapeutic
molecule for the treatment of cancer. To strengthen the utilization of this combination
therapy in cancer therapy trials, further research is warranted.