02216nam a22001577a 4500 610 Iqbal, Arfa 120890 Effect of PEG coating on the Vitexin liposomes for Oral treatment of ALD / Arfa Iqbal Islamabad : SMME- NUST; 2022. 56p. Soft Copy 30cm Vitexin a natural flavonoid, occasionally used in pharmaceutics due to its variety of medicinal effects and its roles in fat metabolism, hepatoprotection, and anticancer therapies. It has been rendered important for diseases leading to chronic liver disease, such as NASH/NAFLD, diabetes, cardiovascular ailments, and Liver cirrhosis. Recently, it has been administered in pure drug formulation, in combination with other chemicals, and nanoparticulate form mostly intravenously for various types of liver diseases. In its pure form it shows lower bioavailability due to its insolubility in aqueous environments and a lower rate of intestinal absorption. Since vitexin is known for its role in reducing and reversing the complications arising from decompensated liver cirrhosis, liposomal nanoparticles encapsulating vitexin were prepared by the ‘thin-film hydration’ process along with passive drug loading. Polyethylene glycol (PEG) coating of vitexin-loaded nanoparticles was used in the oral treatment of advanced liver disease in this research. Wistar rat models of intense liver injury was prepared and treated with vitexinloaded liposomal nanoparticles coated with PEG-1000 and PEG-2000. Histopathological, serological analysis and various other parameters observed and analyzed during and after the disease induction and completion of the treatment protocol presented better results and a possible reversal of liver cirrhosis when nanoparticles were coated with PEG-2000 in oral treatment. PEG-2000 also shows positive role in the oral administration to match the effectiveness of previously used vitexin-loaded nanoparticles for intravenous treatment of liver cirrhosis. MS Biomedical Sciences 119475 Supervisor : Dr. Nosheen Fatima Rana http://10.250.8.41:8080/xmlui/handle/123456789/31846 ddc THE 607922 607922 0 0 0 0 SMME SMME EB 2024-02-20 0 610 SMME-TH-807 2024-02-20 2024-02-20 THE