Sohail, Sana creator Supervisor : Dr. Adeeb Shehzad text monographic 59p. Soft Copy 30cm Sana Sohail Vaccination was the only method available to stop the COVID-19 epidemic once it had started. There is skepticism about the efficacy and safety of current COVID-19 vaccination around the world. Because glycemic alterations have been observed after immunization, there were significant worries regarding post-vaccination unfavorable consequences in the diabetic community. The purpose of this study is to examine the adverse effects of post-COVID-19 vaccination in diabetic and non-diabetic subjects who received various types of vaccinations, including inactivated viral vaccines (Sinopharm and Sinovac), RNA-based vaccines (Moderna and Pfizer), and nonreplicating-viral vaccines (AstraZeneca and Casino bio). This study aims to investigate the concomitant side effects caused by different COVID-19 vaccines in diabetic and non-diabetic populations by questionnaire, interviews, and analysis of blood samples for different biomarkers. Data collected was analyzed using IBM-SPSS by applying an independent sample T-test, chi-square test, and binary logistic regression. Most of the side effects were reported within the age group 31-40 and 41-50. There is no significant difference in side effects after vaccination in diabetic and non-diabetic individuals. The glycemic imbalance was seen high in individuals vaccinated with RNA-based vaccine with n=27(31.2%) reporting high blood sugar levels. Concluded that these vaccines are safe for diabetic individuals but keeping results in view RNA-based vaccines should be administered with blood glycemic levels in check. MS Biomedical Sciences (BMS) 610 http://10.250.8.41:8080/xmlui/handle/123456789/31044 http://10.250.8.41:8080/xmlui/handle/123456789/31044