01318nam a22001457a 4500003000500000082000800005100002000013245010300033264003800136300002900174500084100203650003601044700003401080856005801114NUST  a610  a Sajjad ,Aleena  aSaikosaponin B2 Protects Against LPS Induced Inflammation In Neuronal Cell Lines /cAleena Sajjad   aIslamabad : bSMME- NUST; c2024.  a76p. ;bSoft Copyc30cm.  aThis study explores the protective effects of Saikosaponin B2, a triterpenoid extracted from the roots of Radix bupleurum against lipopolysaccharide-induced inflammation, a common model for studying neurodegenerative diseases. LPS induces strong immune reactions, activating pro-inflammatory cytokines, increases ROS generation, ultimately leading to neuronal damage and loss. We theorized that Saikosaponin B2 holds an anti-inflammatory and anti-oxidant profile capable of mitigating LPS-induced effects. An in-vitro model was used to determine the extract’s effectiveness in reducing inflammatory gene expression, ROS generation and activation of injury mechanisms. Our results show that Saikosaponin B2 reduces LPS-induced inflammation, signifying its possible utilization as a therapeutic agent against neurodegenerative diseases.  aMS Biomedical Sciences (BMS)     aSupervisor: Dr. Adeeb Shehzad  u http://10.250.8.41:8080/xmlui/handle/123456789/46178