Khan, Rida Khalid creator Supervisor : Dr. Nosheen Fatima text monographic 68p. Soft Copy 30cm Rida Khalid Khan The development and evaluation of an advanced nanocarrier hydrogel system designed to address the major barriers in diabetic wound healing, specifically targeting chronic inflammation, oxidative stress, bacterial infection, and impaired angiogenesis. This therapeutic system integrates cerium oxide nanoparticles (CeO₂), metal-organic frameworks (MOFs), and a chitosan-gelatin hydrogel platform to create a multifunctional wound dressing. CeO₂ nanoparticles provide strong antioxidant and antibacterial activity, MOFs enable controlled drug release and add antimicrobial properties, while the chitosan-gelatin hydrogel ensures biocompatibility, moisture retention, and accelerated tissue repair. Comprehensive characterization, including Raman spectroscopy, FTIR, UV-Vis, EDX analysis, and optical microscopy, confirmed successful synthesis, structural integrity, and the presence of desired functional groups. Biological assays demonstrated superior antibacterial and antibiofilm performance of the CeZn-Gel composite against E. coli and S. aureus, surpassing individual system components and controls. The integrated approach not only enhances wound healing outcomes but also reduces infection and inflammation, with significant potential for improving patient quality of life in chronic wound care. Future work will focus on optimizing formulation and advancing toward clinical testing for broader therapeutic impact. MS Biomedical Sciences (BMS) 610 http://10.250.8.41:8080/xmlui/handle/123456789/55616 http://10.250.8.41:8080/xmlui/handle/123456789/55616