For the development of complex multifunctional materials as advanced wound dressings for the treatment of skin diseases, particularly chronic and infected wounds. By integrating cerium oxide nanoparticles and thymol-based deep eutectic solvent hydrogels into a chitosan-gelatin matrix, the study addresses pressing challenges in wound care, including antimicrobial resistance, limited drug stability, and poor localization at wound sites. Engineered hydrogels provide sustained release of active compounds, effectively disrupt biofilms from resistant bacteria such as Staphylococcus aureus and Escherichia coli, and deliver combined antimicrobial, antioxidant, and antiinflammatory effects. Laboratory evaluations demonstrated significant antibacterial activity, enhanced biofilm inhibition, and improved healing potential compared to conventional therapies. The results establish these materials as strong candidates for next generation wound dressings, with future research focused on optimizing formulation stability and validating in vivo safety. This work contributes to advancements in wound management by offering promising solutions for minimizing antimicrobial resistance and enhancing healing outcomes in chronic skin infections.