01724nam a22001577a 4500 610 Riaz, Aqsa 121483 Complex Materialsfor Skin Diseases / Aqsa Riaz Islamabad : SMME- NUST; 2025. 65p. Soft Copy 30cm For the development of complex multifunctional materials as advanced wound dressings for the treatment of skin diseases, particularly chronic and infected wounds. By integrating cerium oxide nanoparticles and thymol-based deep eutectic solvent hydrogels into a chitosan-gelatin matrix, the study addresses pressing challenges in wound care, including antimicrobial resistance, limited drug stability, and poor localization at wound sites. Engineered hydrogels provide sustained release of active compounds, effectively disrupt biofilms from resistant bacteria such as Staphylococcus aureus and Escherichia coli, and deliver combined antimicrobial, antioxidant, and antiinflammatory effects. Laboratory evaluations demonstrated significant antibacterial activity, enhanced biofilm inhibition, and improved healing potential compared to conventional therapies. The results establish these materials as strong candidates for next generation wound dressings, with future research focused on optimizing formulation stability and validating in vivo safety. This work contributes to advancements in wound management by offering promising solutions for minimizing antimicrobial resistance and enhancing healing outcomes in chronic skin infections. MS Biomedical Sciences (BMS) Supervisor : Dr. Nosheen Fatima Rana http://10.250.8.41:8080/xmlui/handle/123456789/55614 ddc THE 615166 615166 0 0 0 0 SMME SMME EB 2025-10-14 0 610 SMME-TH-1188 2025-10-14 2025-10-14 THE