02283nam a22001577a 4500 610 Hadiqa Shahid 132706 Cinnamon-derived Carbon Dots as Therapeutic Intervention for Cognitive Impairment and Neuropathy Associated With Diabetes / Shahid, Hadiqa Islamabad : SMME- NUST; 2025. 151p. Soft Copy 30cm Diabetes mellitus, a chronic metabolic disorder affecting over 589 million adults globally, induces diabetes-associated cognitive impairment and peripheral neuropathy through sustained hyperglycemia, oxidative stress, neuroinflammation, and blood-brain barrier dysfunction. Existing therapies inadequately target both central and peripheral neural damage due to poor blood-brain barrier penetration. This study developed cinnamon barkderived carbon nanodots (CIN-CNDs) conjugated with chenodeoxycholic acid (CINCDCA) via green hydrothermal synthesis as a novel nanotherapeutic for diabetesassociated complications. Characterization using UV-Visible spectroscopy, Fourier Transform Infrared spectroscopy (FTIR), Atomic Force Microscopy (AFM), and Scanning Electron Microscopy (SEM) confirmed nanoscale particle formation (average 4.4 nm), successful functionalization, and surface morphology suitable for biomedical applications. Physicochemical testing demonstrated excellent hemocompatibility (<5% hemolysis), high drug loading efficiency (85 ± 3%), pH-stable hydrolytic stability across physiological ranges, and controlled sustained release profile over 72 hours. In streptozotocin-induced diabetic mice, CIN-CDCA nanoconjugates (10 mg/kg, i.p., 1, 4, 14 days) showed significant improvements across comprehensive neuropathic pain assessments (cold allodynia, hot plate, paw pressure, tail immersion; all p<0.01) and cognitive function tests (Morris water maze, Y-maze, novel object recognition, open field).CIN-CDCA nanoconjugates demonstrate biocompatibility, targeted delivery, and disease-modifying efficacy for diabetes-associated neural complications, warranting clinical translation. MS Biomedical Sciences (BMS) Supervisor : Dr. Aneeqa Noor 119519 http://10.250.8.41:8080/xmlui/handle/123456789/57138 ddc THE 615768 615768 0 0 0 0 SMME SMME EB 2026-01-05 0 610 SMME-TH-1203 2026-01-05 2026-01-05 THE