01762nam a22001577a 4500 610 Abbasi, Aliza Anwaar 133194 Novel Bioactive Dental Fillings for Secondary Caries / Aliza Anwaar Abbasi Islamabad : SMME- NUST; 2026. 64p. Soft Copy 30cm Secondary caries rests as the most important challenge in resin-based dental composites, encouraging search of bioactive fillers like silanized hydroxyapatites and fluorides to increase antibacterial performance without negotiating mechanical integrity. This study developed and verified novel UDMA-based composites: a control with camphorquinone photoinitiator, whereas the experimental group integrating APTES-silanized hydroxyapatite plus calcium fluoride. Antibacterial efficacy was evaluated via disk diffusion assays against Staphylococcus aureus and Escherichia coli, revealing clear zones of inhibition nearby experimental disks greater than controls representing fluoride-driven disruption of bacterial growth. Wide-ranging characterization, including SEM, FTIR, EDX analysis, water absorption and solubility done by the use of artificial saliva confirmed efficacious synthesis, structural integrity, and the existence of preferred functional groups. Outcomes highlight these formulations potential to limit oral biofilms and improve restorative durability, with silanization helping filler dispersion and ion release; future work should measure mechanical properties and continuing fluoride kinetics for medical translation. MS Biomedical Sciences (BMS) Supervisor: Dr. Sabah Javaid 128370 http://10.250.8.41:8080/xmlui/handle/123456789/57400 ddc THE 616199 616199 0 0 0 0 SMME SMME EB 2026-02-13 0 610 SMME-TH-1209 2026-02-13 2026-02-13 THE