NUST Institutions Library Catalogue Search for 'au:"Supervisor : Dr. Nosheen Fatima Rana"'

Bioactive Polymer Membranes From Cannabis Sative

By Ismara Nadir . Islambad SMME NUST 2015 . 55P. 30cm.

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Effect of Berberis lycium flavonoids on colonization of Enteroccus faecalis in mice /

By Sundas Riaz. Islamabad : SMME - NUST, 2015 . ill, 63 p. ; , Hardcover.

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Doxorubicin & Disulfiram-metabolite Loaded Nanocarriers for The Effective Combination Therapy Against Acute Myeloid Leukaemia /

By Tariq, Urooba . . 150p. 30cm.

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Nanoencapsulation of Ferrocene Incorporated Thiourea and Doxorubicin for Treatment of Acute Myeloid Leukemia /

By Idrees, Nimra . . 102p. 30cm.

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Elucidation of Therapeutic Potential of Caffeine Nanoparticles against Acute Myeloid Leukemia / Usama Sabir

By Sabir, Usama. . 88p. 30cm.

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Evaluation of the anti-cancerous effect of ciprofloxacin loaded liposomes against leukemia in rat model /

By Fatima, Sahar. . 86p. 30cm.

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Potential Inhibition of Lactate Dehydrogenase by Oxamate in Enterococcus faecalis /

By Raza, Laiba Hareem . . 72p. 30cm.

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Ciprofloxacin-Gold Nanoparticles Loaded Polymeric Membrane as a Novel Antibacterial Wound Dressing against Diabetic Foot Ulcer Infection /

By Malik, Hadiya . . 77p. 30cm.

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Effect of Etoposide loaded Nanoparticles in the Treatment of Advanced Liver Diseases /

By Iqbal, Zarqa . . 76p. , Advanced liver diseases (ALD) continue to pose significant health challenges due to their high global prevalence and limited currently available curative options, besides liver transplantation. Liver disease therapeutics include many substances that may have insufficient effectiveness and severe adverse effects, such as Etoposide, having toxic nature with low compatibility and solubility in an aqueous solution. Nanoparticle-based therapeutics emerged as an efficient and safe treatment option to minimize side effects. Etoposide used for ALD is more toxic with low biocompatibility and solubility in an aqueous solution which makes it less efficient. The purpose of the study is to use nanoparticle-based etoposide for the treatment of ALD by improving its biocompatibility and solubility which makes this target-based therapy less toxic and more effective. Rat models used in this study were introduced with CCL4 and Urethane co-administration to develop liver cirrhosis. The thin film hydration method was used to synthesize etoposideencapsulated liposomal nanoparticles. The stability and stealth effect of liposomes were enhanced by polyethylene glycol (PEG) coating. Etoposides and PEG-coated etoposide liposomes were administered intravenously, into diseased rats. Results showed that etoposide and PEG-coated liposomal encapsulation are highly effective as compared to etoposide alone and blank nanoparticles and hence, be a substantial strategy for the treatment of ALD through intravenous drug delivery system. 30cm.

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Formation of Ciprofloxacin Loaded Transethosomes to Check the Antibacterial Activity Against Skin Infections /

By Tariq, Huraira. . 67p. , One of the serious challenges in the treatment of infectious diseases is the presence of bacterial infections in subcutaneous wound tissue. Staphylococcus epidermidis (S. epidermidis) and Propionibacterium acne (P. acne) are resistant bacterial strains that cause severe disease in humans when penetrating the deeper layer of skin. Antibacterial drugs with a nonspecific target have more difficulty in penetrating the deeper layer of infected skin. Broad spectrum antibiotics are best to treat the infection but are not commonly used because bacteria’s make resistance against them. To overcome these issues, a combined strategy of broad-spectrum antibacterial drug and nanoparticle was formulated for targeted delivery, enhanced penetration to the infection site specifically. The ciprofloxacin was entrapped in transethosomes and formulation was synthesized by using the cold method. Transethosomes are very small in size that can reach the deeper layer of skin to give potential effects. In the layers of skin, ciprofloxacin works by binding to the enzymes topoisomerase IV and DNA gyrase and inhibit the DNA replication in bacteria. The antibacterial activity of ciprofloxacin loaded transethosomes against skin infections was assessed using Staphylococcus epidermidis and Propionibacterium acne and the method used was well diffusion method. The characterization of ciprofloxacin loaded transethosomes was done through, zeta potential, particle size evaluation, and drug release efficiency. Loaded transethosomes displayed substantially have more potential effect than ciprofloxacin alone. The in-vitro studies show that ciprofloxacin loaded transethosomes boost the antibacterial activity of ciprofloxacin against gram positive. 30cm.

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LIPOSOMAL DOXORUBICIN FOR THE TREATMENT OF ADVANCED LIVER DISEASE /

By Khan, Faryal . . 59p. , Nanoscale materials are utilized as diagnostic instruments or to administer therapeutic substances to specific targeted regions in a controlled manner in the fields of nanomedicine and nano drug carriers, which are still relatively young but are quickly evolving. Nanoparticles can potentially deliver medications more accurately because they are currently made from biocompatible materials. The treatment of advanced liver disease has benefited greatly from nanomedicine in previous decades. Nano-based drug delivery systems improve the effectiveness of medications. Today, advanced liver disease is being treated with liposomal nanoparticles. Nano-based drug delivery systems increase the efficacy of both new and existing treatments through a detailed investigation of nanoparticle manufacturing and utilization. One of the most often used anticancer medications is doxorubicin. Doxorubicin (DOX) is a medication that is frequently used to treat HCC. Doxorubicin is a medicine that belongs to the anthracyclines class and is commonly used to treat different types of cancers, including lymphomas, leukemias, breast, ovary, thyroid, and lungs. Doxorubicin interacts with nitrogen - containing bases of DNA and prevents the production of macromolecules. This, in turn, prevents the action of the enzyme topoisomerase II (Top II), which inhibits the replication process. Consequently, malignant cells are prevented from proliferating. According to early research, doxorubicin's cardiotoxicity is reduced when it is encapsulated inside liposomes. Due to its cardiotoxicity, the "thin film hydration approach" was utilized to create doxorubicinencapsulated liposome nanoparticles, which were then used to treat advanced liver disease. The liposome nanoparticles were coated with polyethylene glycol (PEG) to boost their stability and provide a stealth effect. Pegylation improves steric repulsion and is therefore regarded as a superior stabilizer for various kinds of nanoparticles. PEG adopts the drug's erosion-controlled release mechanism, which led to continuous release. It is noted that a significant technique to treat NAFLD is to encapsulate the doxorubicin drug within liposomes and modify these liposome nanoparticles via PEG. 30cm.

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Oral Administration of Fluoxetine Incorporated Liposomal Nanoparticles coated with PEG in Treatment of Chronic Mild stress (CMS) /

By Sadiq, Nadia . . 55p. , Depression is one of the most increasing psychological mood disorders, depression does not have some specific physical symptoms, but it negatively affects the person mood, way of living and thinking chronic mild stress (CMS) is one of its type, depression is affecting more than 300million people in the world. Shortness of breath, headache, being miserable, stomach disturbance and physical tensions are some of the common symptoms of depression that is reported according to National Alliance of Mental Health, Anti-depressant are used for altering the neurotransmitters those are serotonin, dopamine and norepinephrine that are primarily involved in regulating and mood alleviating mood. Despite the availability of large number of drugs, many of patients are resistant to the current mode of treatment that are available now adays. The obstacle that is significant for the transportation of beneficial therapeutic entities to the nervous system is BBB that is the blood brain barrier. There are junctions that are present in the endothelial cells of the blood brain barrier that stop the drugs passage. Now nanoparticles are receiving significant limelight owing to their small size and efficient brain targeting activity, making them likely to cross the blood brain barrier while carrying the intact drug molecule otherwise incapable of permeation. In this study the fluoxetine loaded liposomal nanoparticle coated with PEG were developed to transport the drug across the BBB to the central nervous system having much greater efficiency. For testing its delivery, the animal that is mice model of depression is used with the specific name that is designed in order to induce depression like symptoms in mice. Before and After treatment great differences between the physical behaviors like Elevated maze, open field test, force swim test etc and sucrose consumption test were identified and plotted, as liposomes that having capabilities to carry the anti-depressant drug molecule that is administered through the Oral route of administration or the better and improved method of treatment. 30cm.

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Validation of Antibacterial Activity of Gossypol against Enterococcus faecalis /

By Rasool, Misbah . . 54p. , Antibiotic resistance is a growing concern today that affects the entire world, necessitating the development of new antibacterial medications. Nosocomial infections pose a serious challenge for patients and hinder effective treatment. The second most common cause of nosocomial infections is Enterococcus faecalis, and it depends on the lactate dehydrogenase enzyme's capacity to maintain redox balance for growth, resistance, and virulence. As demonstrated before by computational technique, our study attempted to assess the antibacterial effect of Gossypol on Enterococcus faecalis by inhibiting Lactate Dehydrogenase Enzyme. We used six different stressors, including 0.01% SDS, 2.5mM H2O2, 8% Ethanol, 10% DMSO, 10% Glucose, and 0.25% HOCl, in addition to our inhibitor Gossypol. Gossypol was employed in the following concentrations: 5, 10, 25, 50, 75, 100, 150, 200 micrograms per milliliter using a large test tube method, absorbance on a UV-visible spectrophotometer, and on a microscale using a 96-well flatbottom plate with a Microplate reader. Between control (Culture Media) and vehicle control, which is DMSO, there is no discernible difference. At higher dosages of Gossypol, such as 100 and 200 micrograms per milliliter, there is significant growth inhibition; nevertheless, 5, 10, 25, 50, 75, and 100 micrograms per milliliter show no significant inhibition. Minimum Inhibitory Concentration is 100 microgram per milliliter. We used our six different stress factors with MIC value of Gossypol. There is no discernible growth inhibition when Gossypol is employed in conjunction with stress factors such 0.01% SDS, 2.5mM H2O2, and 0.25% HOCl. However, at 100 micrograms per milliliter at the fourth and fifth hours, glucose 10% exhibits a strong inhibitory impact, though not by a great deal. Along with MIC value of Gossypol, 100 micrograms per milliliter, 8% ethanol and 10% DMSO significantly slowed the development of the bacteria. The lactate dehydrogenase enzyme in Enterococcus faecalis was effectively inhibited by gossypol. Future in vivo studies are required to demonstrate the antibacterial activity of Gossypol in greater detail, as well as to compare it to antibiotics as an adjunctive treatment. 30cm.

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Effect of PEG coating on the Vitexin liposomes for Oral treatment of ALD /

By Iqbal, Arfa . . 56p. , Vitexin a natural flavonoid, occasionally used in pharmaceutics due to its variety of medicinal effects and its roles in fat metabolism, hepatoprotection, and anticancer therapies. It has been rendered important for diseases leading to chronic liver disease, such as NASH/NAFLD, diabetes, cardiovascular ailments, and Liver cirrhosis. Recently, it has been administered in pure drug formulation, in combination with other chemicals, and nanoparticulate form mostly intravenously for various types of liver diseases. In its pure form it shows lower bioavailability due to its insolubility in aqueous environments and a lower rate of intestinal absorption. Since vitexin is known for its role in reducing and reversing the complications arising from decompensated liver cirrhosis, liposomal nanoparticles encapsulating vitexin were prepared by the ‘thin-film hydration’ process along with passive drug loading. Polyethylene glycol (PEG) coating of vitexin-loaded nanoparticles was used in the oral treatment of advanced liver disease in this research. Wistar rat models of intense liver injury was prepared and treated with vitexinloaded liposomal nanoparticles coated with PEG-1000 and PEG-2000. Histopathological, serological analysis and various other parameters observed and analyzed during and after the disease induction and completion of the treatment protocol presented better results and a possible reversal of liver cirrhosis when nanoparticles were coated with PEG-2000 in oral treatment. PEG-2000 also shows positive role in the oral administration to match the effectiveness of previously used vitexin-loaded nanoparticles for intravenous treatment of liver cirrhosis. 30cm.

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Essential Oil (Eo) Blend Loaded Solid Lipid Nanoparticles (Slns) As Novel Deodorant /

By Zahra Rehman, Zahra Rehman. . 66p. , Human odors have been of great concern to society. The generation of malodor on the skin surface of modern humans is caused by the biotransformation of naturally secreted non-odorous precursor molecules into volatile odorants by members of the commensal microbiome. Culture-based microbiological studies revealed that the axillary microbiota consists primarily of Gram-positive bacteria of the genera Staphylococcus, Corynebacterium, and Propionibacterium. Currently there is need to study the selective suppression of the growth of microorganisms involved in diseases and unpleasant odors may result in the establishment of a good symbiotic relationship between microorganisms and humans. As the growth of axillary microbiota which causes odor can be controlled by several ways including hygiene and antimicrobial skin friendly essential oils. Given the limitations in currently available products, a deodorant/antiperspirant formulation that effectively prevents body odor without producing skin sensitivity or perceived undesirable consequences is required. Our work is the deodorant production which is made from all naturally extracted products which includes the lipid which sources from whale fish and is completely alcohol and toxins free. This deodorant is fabricated using lecithin, solid lipid nanoparticles, natural essential oils, and fragrance which are incorporated in a gel. The gel phase contains triethanolamine, TEA and Carbopol-940. TEA is used in safer limits for the polymerization of Carbopol-940 to form a clear gel. The essential oils used possess antibacterial properties which are effective against sweat bacteria. The deodorant is aluminium and parabens free as they contribute to cancer development and hormonal imbalance. 30cm.

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In-Vivo Evaluation Of Silymarin Encapsulated Liposomal Nanoparticles In Chronic Mild Stress (Cms) Model And Depression Induced Liver Disorders /

By Fatima, Misha. . 77p. , Depression is categorized as one of the most prevalent psychological disorders that affect personal wellbeing and social life of individuals. Symptoms vary from anhedonia to suicide commitment. The molecular mechanism behind is the low concentration of neurotransmitters serotonin, dopamine and norepinephrine in central nervous system. These are primarily responsible for regulating and alleviating mood. In the chronic mild stress (CMS) model of depression, silymarin, a plant-derived polyphenolic flavonoid of Silybum marianum, elicited strong antidepressant-like action. It increased the levels of monoamines, particularly 5-hydroxytryptamine (5-HT) in the cortex and dopamine (DA) in the mice hippocampal region and prefrontal cortex. The objective of the current research was to investigate silymarin's antidepressant potential in CMS-induced depressive-like behavior in mice and to identify its potential mechanism(s) of action. The mice were given silymarin and silymarin loaded liposomal nanoparticles (SLNPs) for two weeks after following CMS protocol for 28 days (4 weeks). Animals were assessed for behavioral alterations, including exploratory activity in an open field test, behavioral despair in a forced swim test, and anxiety-like behaviors in an elevated plus maze test. There lies a close relationship between depression and inflammatory liver diseases. Hence the effect of depression on liver has also been checked. Silymarin is a commercially available hepatoprotective drug but due to its antioxidant properties, research has been conducted to evaluate its neuroprotective effect and hence its prescription as antidepressant drug. However, due to its poor solubility and bioavailability there is delay in the onset of treatment outcomes in many individuals. Certain side effects and contraindications are also important regimen opponents. In this study, Silymarin loaded liposomal nanoparticles (SLNPs) are prepared, characterized, and realized for the depression treatment in Chronic Mild Stress (CMS) mice model of depression and its treatment efficiency on symptoms of inflammatory liver diseases in mice as well. It presented face construct and validity response. As such the SLNPs present improvement in depression measurement parameters as compared to the simple silymarin. The SLNPs also positively impacted the aggression, anhedonia and rearing in mice, however simple silymarin treated mice did not show improvement in social and personal behavior. As such SLNPs compensated for delayed onset of fluoxetine response. 30cm.

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Investigation of Silymarin Encapsulated Liposomal Nanoparticles Against Copper Toxicity Associated Liver Dysfunction and Neurobehavioral Abnormalities in Wistar Rats /

By Maryam, Tuba . . 69p. , The fields of nanomedicine and nano delivery systems, in which nanoscale materials are utilized as diagnostic instruments or to administer therapeutic medicines to precisely targeted areas, are new but rapidly developing fields. Through a thorough examination of nanoparticle production and use, nanomedicines and nano-based drug delivery systems improve the effectiveness of both new and existing treatments. Recent years have seen a surge in interest in the use of nanoparticulate structures including stimuli-sensitive polymers and liposomes for the treatment of liver disorders. Wilson disease is characterized by copper accumulation in both the liver and extrahepatic organs. The liver is particularly vulnerable to chronic copper poisoning because it is the first organ to absorb copper from the circulation. Copper's toxicity manifests in several ways, including liver cirrhosis, hemolytic anemia, renal tubule injury, damage to the brain and other systems. The available therapies aim to lower copper levels by various means. However, a potent therapeutic drug that can repair the damaged brain and liver tissue is desperately needed. Milk thistle (Silybum marianum L.), a member of the Carduus marianum family, has been used for decades to treat liver and gallbladder problems. Medical researchers have shown silymarin and silibinin to have hepatoprotective, antioxidant, and cytoprotective properties. The effectiveness of silymarin as a medication for the liver is diminished by its poor water solubility and low oral bioavailability. In order to get around these problems, the "thin film hydration method" was used for synthesizing liposome nanoparticles that are encapsulated with silymarin and may be used to combat copper toxicity. Polyethylene glycol (PEG) was employed to coat the liposome nanoparticles to increase their stability and to induce the stealth effect. After the induction of copper toxicity in rats, various methods such as serological analysis and behavioral tests were carried out to assess the effectiveness of the different treatment plans. The silymarin liposome nanoparticles showed improved treatment as compared to silymarin. The combination therapy of the liposomes along with zinc proved to be a more effective treatment plan than zinc therapy. 30cm.

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Analyzing The Hepatoprotective Effects Of Silymarin Encapsulated Pegylated Liposomal Nanoparticles And Vitamin D & E For Targeted Nafld Treatment In Wistar Rats /

By Batool, Farhat . . 78p. , Nanotechnology-based therapeutics have recently emerged as an inventive and optimistic replacement for traditional therapy. Currently, biocompatible materials are used to create nanoparticles and they have the potential to deliver drugs more precisely, either inactively by enhancing the drug nanocarriers' physicochemical characteristics or actively by applying homing technologies tailored to particular tissues or cells that enable disease site targeting while minimising side effects. Because of their ability to overcome a wide range of biomedical, biological or biophysical constraints, NPs can be developed as nanoplatforms for efficient drug delivery. Silymarin has a diverse set of in vitro and in vivo actions, including antioxidant, antiinflammatory, dose-dependent anti-apoptotic, and cell transporter altering properties. As a result, it has the potential to be a promising medication in alternative medicine. However, oral silymarin has a low bioavailability, which restricts its medical applications. But the bioavailability of silymarin can be increased by using liposomes as drug delivery systems. In the current study, the silymarin-loaded pegylated liposomal nanoparticle was successfully created and employed as a treatment for NAFLD. Liposomal NPs can be created as nanoplatforms for the effective and targeted delivery of drugs due to their ability to pass through a number of biological, biophysical, and biomedical barriers To overcome the drawbacks, silymarin encapsulated liposome nanoparticles were synthesized utilizing DPPE by the ‘thin film hydration method’ and used against liver cirrhosis for the first time. To enhance the stability, Polyethylene glycol (PEG) was used to enhance stability and for inducing the stealth effect, by coating the liposomes nanoparticles. Pegylation enhances the steric repulsion and is hence known a as better stabilizer for different types of nanoparticles. PEG follows the erosion-controlled release mechanisthe m of drug that resulta ed in sustained release. Hence, it is noteworthy that encapsulating the silymarin drug within liposomes and tailoring these liposome nanoparticles by PEG, is a substantial strategy to combat NAFLD. 30cm.

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DESIGN AND FABRICATION OF SUTURE-LESS WOUND CLOSURE DEVICE /

By ASHRAF ,USMAN . . 59p. ; 33cm..

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Ciprofloxacin Loaded Gold Nanoparticles for the Eradication of Enterococcus faecalis in Liver and Kidney of Mice /

By ALI ,SYED MOHSIN. . 65p. ; 30cm..

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Administration of Fluoxetine incorporated Liposomal Nanoparticles in the treatment of Learned Helplessness model of Depression /

By Ali , Mariyam . . 66p. ; 30cm..

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Discovery of Potent LasR Inhibitor Using Pharmacophore Informatics Strategy /

By Sadiq , Suhaib. . 103p. ; 30cm..

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LIPOSOMAL ENCAPSULATION OF VITEXIN AND ITS IN VIVO ANALYSIS AGAINST LIVER CIRRHOSIS /

By Farooq , Adil . . 70p .; 30cm..

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Role of Vitexin Liposomes in Treatment of Depression /

By ATHAR, RIDA . . 62p. ; 30cm..

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Role of Schisandrin-A against Enterococcus faecalis in-vitro studies /

By Bibi, Sabina . . 98p. , This study delves into the investigation of Schisandrin-A's antibacterial efficacy against Enterococcus faecalis jh2-2, a pathogenic strain associated with escalating concerns of antibiotic resistance. Recognizing the pressing need for alternative treatments, we employed a multifaceted approach, including Minimum Inhibitory Concentration (MIC) testing, DNA extraction, Time-Kill Kinetics assays, and Scanning Electron Microscopy. Through meticulous MIC testing, concentration-dependent antibacterial effects of Schisandrin-A were revealed, showcasing its potential as a potent agent against Enterococcus faecalis. Drug DNA interaction techniques provided insights into the molecular dynamics of the compound's interaction, unraveling potential structural changes and binding modes with bacterial DNA. The Time-Kill Kinetics assays further elucidated the bactericidal activity of Schisandrin-A over varying concentrations and time intervals. These assays offered a comprehensive understanding of the compound's impact on bacterial viability, providing valuable data for assessing its therapeutic potential. Scanning Electron Microscopy unveiled morphological changes induced by SchisandrinA, shedding light on its mechanisms of action at a microscopic level. These findings collectively contribute to a nuanced comprehension of Schisandrin-A's antibacterial effects, offering insights into its potential application in combating antibiotic-resistant strains, particularly Enterococcus faecalis jh2-2. This research holds significant implications for public health, addressing the challenges posed by antibiotic-resistant bacterial strains. The identified antibacterial properties of Schisandrin-A provide a foundation for further exploration and development of alternative therapeutic strategies, aiming to mitigate the risks associated with conventional antibiotic treatments. By vii unraveling the complex interplay between Schisandrin-A and Enterococcus faecalis jh2- 2, this study contributes to the ongoing efforts to confront the global issue of antibiotic resistance and enhance the arsenal of effective antibacterial agents. 30cm.

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Encapsulation of Lauric Acid inside the Polymers and use against Sweat Bacteri /

By Shah, Wajeeha . . 63p. , In society, the problem of human odor has caused serious problems. The development of Disagreeable odor on the skin of contemporary humans is the consequence of the commensal microbiota converting naturally released, odourless precursor molecules into Volatile odorants. Human odour is a major problem in society which originates from commensal bacteria that converts odourless compounds into volatile odorants on the skin that cause bad smell. The majority of the axillary bacteria consist of gram-positive bacteria such as Corynebacterium, Propionibacterium and Staphylococcus. There is a need for a deodorant/antiperspirant composition that successfully avoids body odor without irritating skin or having unfavourable effects, considering the shortcomings of current solutions. Use of essential oils and maintaining good hygiene play vital role in maintaining the microbiota development. The existing deodorants are problematic because they contain aluminium and other toxins that can affect the skin so a natural alternative that avoids irritants like aluminium and toxins is recommended. This research paper emphasized the synthesis of deodorants containing the naturally occurring fatty acids like Lauric acid, which is well known for its antibacterial properties. Polymers e.g. Chitosan, Polyvinyl alcohol and Gelatin is use in this formulation. Lecithin and Ethanol are used to dissolve lauric acid in the gel. Remarkably, neither aluminium nor parabens are present in the deodorant because they are connected to cancer and hormone imbalance. 30cm.

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Administration of Fluoxetine incorporated Liposomal Nanoparticles in Chronic Mild Stress (CMS) Animal Model for the treatment of Depression /

By Farwa Mehmood. . 56p. ; 30cm..

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Synthesis and Characterization of Etoposide Loaded Nanostructured Lipid Carriers and Their Targeted Delivery to Cancerous Cells /

. 52p, ; 30cm..

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Effectiveness of Se/ZnO NPs in enhancing antibacterial activity of resin based dental composite /

By Saleem, Iqra. . 65p. , Biofilm formation in the resin-composite interface is a major challenge of resin based dental composites that may lead to secondary caries formation. The use of nanoparticles (NPs) to enhance the antibacterial properties of resin composites are highly desired. The present study focused on effectiveness of Se doped ZnO (Se/ZnO) NPs as an antibacterial nanofiller and its impact of mechanical properties of the resin composites. Pristine and Se/ZnO NPs were synthesized by the mechanochemical method, and confirmed through UV-Vis Spectroscopy, FTIR (Fourier Transform Infrared) analysis, X-ray Diffraction (XRD) crystallography, Scanning Electron Microscopy (SEM), Energy Dispersive Spectroscopy (EDS), and Zeta analysis. The resin composites were then modified by varying concentrations of pristine and Se/ZnO NPs. For the antibacterial analysis, a single specie (S. mutans and E. faecalis) and a saliva microcosm model was utilized. Hemolytic assay and compressive strength tests were also performed to test the cytotoxicity and mechanical strength of modified composite resin. 1% Se/ZnO NPs when incorporated in composite resin showed higher antibacterial activity, higher biocompatibility, and higher mechanical strength when compared to composites with 1% ZnO NPs. Mechanical strength was unaffected by addition of Se/ZnO NPs. Furthermore, the hemolytic activity was also within the safe limit. Se/ZnO NPs can be used as efficient antibacterial nanofiller for resin composites and are effective in preventing secondary caries formation. 30cm.

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Antibacterial Activity of Dental Composite integrated with Ciprofloxacin loaded Silver Nanoparticles /

By Arif, Wafa. . 68p. , Resin composites have been widely used in dental restoration. However, polymerization shrinkage and resultant bacterial microleakage is a major limitationthat may leads to secondary caries. To overcome this, a new type of antibacterial resincomposites containing ciprofloxacin loaded silver nanoparticles were synthesized. Ciprofloxacin loaded silver nanoparticles were successfully synthesized withchemical reduction method which was confirmed by Ultraviolet–visible (UV-Vis) spectroscopy, Scanning Electron Microscopy (SEM), Fourier-transforminfraredspectroscopy (FTIR) and Zeta potential. Ciprofloxacin loaded silver nanoparticles were added into resin composites. The antibacterial properties of these ciprofloxacinloaded silver nanoparticles modified resin composites against Enterococcus faecalis, Streptococcus mutans and Saliva Microcosm model were evaluated. Cytotoxicityof these modified resin composites was determined by performing hemolytic assay. Compressive strength (CS) of these modified resin composites was assessed byauniversal testing machine. The results indicated that the antibacterial activityandcompressive strength of resin composites containing Ciprofloxacin loaded silver nanoparticles were superior to the control group and also exhibited less cytotoxicityas compared to the resin composites containing silver nanoparticles. In short, theseresults established strong ground applications for CIP-AgNPs modified dental composite resins. 30cm.

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DEAE-Dextran coated AgNPs for antibacterial composite based dental fillings /

By Azhar, Shabia . . 59p. , The major dental problem now a days is occurrence of dental caries. To cope with them, the best treatment option considered today is restorative material fillings. There is observed few problems with utilization of composite material. The accumulation of biofilm over these dental composite resins is a major cause of secondary caries. Antibacterial restorative resins are an effective option to avoid biofilm accumulation. The aim of this research was to synthesize novel Diethylaminoethyl (DEAE)-dextran silver nanoparticles (AgNPs) and to modify dental composite resins utilizing these NPs. The antibacterial and antibiofilm properties of these composites were evaluated and compared with unmodified composites. Furthermore, these modified composite resins were assessed for their mechanical and cytotoxic activity. DEAEDextran AgNPs of mean size i.e., 170nm were successfully synthesized with chemical reduction method which was confirmed by Ultraviolet–visible (UV-Vis) spectroscopy, Scanning electron microscopy (SEM), Fourier-transform infrared spectroscopy (FTIR), Zeta potential and Energy-dispersive X-ray spectroscopy (EDS). Antibacterial activity of modified composite disc specimens was tested against Streptococcus mutans (S. Mutans), Enterococcus faecalis (E. Faecalis) and microcosm biofilms. The composite discs prepared with DEAEDextran AgNPs exhibited excellent antibacterial activity when compared with composite resin reinforced with simple AgNPs. Also, composite resins with DEAE-Dextran AgNPs exhibited enhanced antibiofilm properties when compared with the silver modified resin composites (P<0.05). The mechanical properties were significantly enhanced by the addition of DEAEDextran into composite resin(P<0.05). Moreover, unlike AgNPs, DEAE-Dextran AgNPs were less haemolytic. In short, these results established strong ground applications for DEAEDextran modified dental composite resins 30cm.

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Calcium Phosphate Based Coating of Hard tissue implants /

By Tariq ,Komel. . 77p. ; , Implant-associated infections remain a significant challenge in orthopaedic and dental implants because they frequently result in implant failure, higher patient morbidity and significant healthcare costs. One of the primary pathogens responsible for these IAIs is Staphylococcus aureus, known for its potential to make biofilms on the surfaces of implants. Hard tissue implants play a crucial role in modern medicine, facilitating the restoration of damaged or lost tissues and improving the quality of life for millions of patients worldwide. In this research, we propose a novel approach to enhance the antibacterial properties of hard tissue implants by fortifying their surfaces with calciumdoped zinc oxide (Ca-ZnO) nanoparticles through biomimetic calcium phosphate coating. Hydroxyapatites [Ca10(PO4)6(OH)2, Hap] are the main constituents of bones and tissues. Calcium phosphate has been playing a role in human hard tissue bio-engineering because of its high biocompatibility and biodegradability. This study aimed to develop Ca2+-dopedZnO nanoparticles (NPs) and investigate their antibacterial properties against microorganisms like Staphylococcus aureus. Ca/ZnO NPs are synthesized by the coprecipitation method and subsequently characterized by scanning electron microscopy (SEM), X-ray diffraction (XRD), UV-vis spectroscopy, and Fourier transform infrared spectroscopy (FT-IR).Significant enhancement in the antibacterial properties was observed in alkaline and heat treated disc coated with Ca-doped ZnO NPs for 14 days compared to 7 days and discs coated with bare ZnO NPs (Staphylococcus aureus, p=<0.0001).These findings suggest that calcium phosphate-based biomimetic coatings, doped with calcium-doped ZnO NPs show great potential for reducing the risk for implant-associated infections. 30cm..

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Silymarin silver nanoparticles loaded biomimetic coating for titanium implants /

By Shahid ,Eman . . 79p. ; , Titanium is most frequently utilized for making orthopedic and orthodontic implants. Titanium implants are most extensively used because of their anti-corrosive properties, having high success rate. Despite high success rate, there still are number of cases in which implant rejection is observed. Surface modification techniques for improving surface properties, surface roughness and their interaction with biological environment has been explored to overcome the risk of implant associated infections. This research aims at designing a silymarin silver nanoparticles loaded biomimetic coating for titanium implants which results in implants having improved anti-biofilm activity, improved osseointegration and biocompatibility. Green synthesis approach is employed for silver nanoparticles synthesis using Silybum marianum L. plant extract, which is rich in free hydroxyl groups which can reduce Ag+ ions into Ag nanoparticles. Titanium implants are bio-inert they cannot interact with the bone to form a bond that limits their osseointegration. Bone like apatite coating on the titanium surface is being explored for improving osseointegration potential of the surface. The potential of silymarin as a reducing agent is confirmed by the UV spectrometry, XRD, FTIR, SEM and zeta potential analysis of silver nanoparticle. Anti-biofilm crystal violet assay confirmed the anti-biofilm potential of the coated titanium discs. SEM analysis showed uniform coating of calcium phosphate and silver nanoparticles on the titanium surface. Decrease in contact angle of the coated titanium disc confirmed increase in the hydrophilicity of the titanium disc, which denotes increase in the osseointegration of titanium discs. 30cm..

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In vitro evaluation of antithrombotic and anticoagulant properties of Silymarin-Silver Nanoparticles using human blood samples /

By Rehman ,Sannan ur. . 113p. ; , This study investigates the anticoagulant and antithrombotic properties of Silymarin Silver Nanoparticles (Sily-Ag NPs) using in vitro human blood samples. Silymarin, a natural flavonoid, was utilized for silver nanoparticles green synthesis, where it served as a reducing as well as a stabilizing agent. Comprehensive characterization of Sily-Ag NPs was done using UV-Vis spectroscopy, Fourier Transform Infrared spectroscopy (FTIR), X-ray Diffraction (XRD), Atomic Force Microscopy (AFM), Zeta potential analysis and Scanning Electron Microscopy (SEM). These analyses confirmed the nanoscale size, crystalline structure, stable surface charge, and effective capping by silymarin, suggesting the potential of these nanoparticles in biomedical applications. The study further evaluated the properties of antithrombosis and anticoagulation of Sily-Ag NPs using a series of coagulation assays, including Activated Partial Thromboplastin Time (aPTT), Fibrinogen levels, Prothrombin Time (PT), International Normalization Ratio (INR), and Thrombin time (TT) assessment. The results demonstrated that Sily-Ag NPs significantly prolonged PT, APTT, and INR, indicating a strong anticoagulant effect by interfering with both pathways of the coagulation cascade be it intrinsic or extrinsic. The findings also suggested that Sily-Ag NPs could effectively inhibit thrombin generation, a critical enzyme in the coagulation process. Interestingly, the Thrombin Time assay did not show any significant change, indicating that the nanoparticles do not directly interfere with concluding step of clot formation, the transformation of fibrinogen to fibrin. However, a modest reduction in fibrinogen levels was seen, which aligns with the overall anticoagulant and antithrombotic effects. The study concludes that Silymarin Silver Nanoparticles possess significant anticoagulant and antithrombotic properties, making them promising candidates for the development of new anticoagulant therapies. These nanoparticles demonstrated the ability to modulate multiple steps in the coagulation pathways without affecting the final fibrinogen-fibrin conversion, potentially offering a targeted therapeutic approach with fewer side effects compared to conventional anticoagulants. To determine Sily-Ag NPs' safety and effectiveness in clinical settings as well as to fully explore their therapeutic potential, more investigation is required, including in vivo experiments and clinical trials. 30cm..

Place Hold on In vitro evaluation of antithrombotic and anticoagulant properties of Silymarin-Silver Nanoparticles using human blood samples /

In vitro evaluation of antithrombotic and anticoagulant properties of Silymarin-Silver Nanoparticles using human blood samples /

By Rehman ,Dr. Sannan ur. . 113p ; , Nanoparticles (Sily-Ag NPs) using in vitro human blood samples. Silymarin, a natural flavonoid, was utilized for silver nanoparticles green synthesis, where it served as a reducing as well as a stabilizing agent. Comprehensive characterization of Sily-Ag NPs was done using UV-Vis spectroscopy, Fourier Transform Infrared spectroscopy (FTIR), X-ray Diffraction (XRD), Atomic Force Microscopy (AFM), Zeta potential analysis and Scanning Electron Microscopy (SEM). These analyses confirmed the nanoscale size, crystalline structure, stable surface charge, and effective capping by silymarin, suggesting the potential of these nanoparticles in biomedical applications. The study further evaluated the properties of antithrombosis and anticoagulation of Sily-Ag NPs using a series of coagulation assays, including Activated Partial Thromboplastin Time (aPTT), Fibrinogen levels, Prothrombin Time (PT), International Normalization Ratio (INR), and Thrombin time (TT) assessment. The results demonstrated that Sily-Ag NPs significantly prolonged PT, APTT, and INR, indicating a strong anticoagulant effect by interfering with both pathways of the coagulation cascade be it intrinsic or extrinsic. The findings also suggested that Sily-Ag NPs could effectively inhibit thrombin generation, a critical enzyme in the coagulation process. Interestingly, the Thrombin Time assay did not show any significant change, indicating that the nanoparticles do not directly interfere with concluding step of clot formation, the transformation of fibrinogen to fibrin. However, a modest reduction in fibrinogen levels was seen, which aligns with the overall anticoagulant and antithrombotic effects. The study concludes that Silymarin Silver Nanoparticles possess significant anticoagulant and antithrombotic properties, making them promising candidates for the development of new anticoagulant therapies. These nanoparticles demonstrated the ability to modulate multiple steps in the coagulation pathways without affecting the final fibrinogen-fibrin conversion, potentially offering a targeted therapeutic approach with fewer side effects compared to conventional anticoagulants. To determine Sily-Ag NPs' safety and effectiveness in clinical settings as well as to fully explore their therapeutic potential, more investigation is required, including in vivo experiments and clinical trials. 30cm..

Place Hold on In vitro evaluation of antithrombotic and anticoagulant properties of Silymarin-Silver Nanoparticles using human blood samples /

Thymol-loaded hydrogels for diabetic wound treatment /

By Shafique ,Maria. , Diabetic wound (DW) healing remains a significant healthcare concern due to prolonged healing times and high infection rates, leading to inadequate treatment outcomes for many patients. Current therapies often fail to address the complex requirement of diabetic wounds, necessitating novel approaches. This study explores the development of a thymolloaded hydrogel as an innovative therapeutic strategy to accelerate the wound healing and prevent infections in patients with diabetes. Thymol, naturally occurring compound with well-documented anti-inflammatory and antibacterial properties, was encapsulated in liposomes to enhance its stability and ensure sustained release at the wound site. These thymol-loaded liposomes were then incorporated into a hydrogel matrix, synthesized through cross-linking polymerization optimized for stability, controlled release, and maintaining a moist wound environment. The hydrogel’s antibacterial efficacy was assessed using the well diffusion method against Staphylococcus aureus and Enterococcus faecalis. Additionally, anti-biofilm assays demonstrated the hydrogel's ability to prevent biofilm formation. In-vivo experiments conducted on a diabetic rat model revealed that wounds treated with this hydrogel exhibited significantly faster healing and improved tissue regeneration compared to untreated controls. These findings suggest that thymolloaded hydrogel represents a promising approach for managing diabetic wounds (DW), offering both accelerated healing and effective infection control. This novel therapeutic approach holds potential for clinical application, improving outcomes for diabetic patients suffering from chronic wounds. 30cm..

Place Hold on Thymol-loaded hydrogels for diabetic wound treatment /

DEAE-Dextran silver nanoparticles-based biomimetic coating for titanium-based hard tissue implant applications /

By Mahmood ,Nawal. . 64p. ; , The improved biomimetic coatings for titanium-based implants have attracted a lot of attention concerning their potential to improve osseointegration and lower the risk of infection. The production, characterisation, and use of DEAE-Dextran silver nanoparticles (AgNPs) as a novel biomimetic covering for titanium-based hard tissue implants are the subjects of this thesis. The DEAE-Dextran, a biocompatible polymer, serves as both a stabilizing and functionalizing agent, facilitating the homogeneous dispersion of AgNPs on the titanium surface. The study employs a comprehensive experimental approach, including chemical synthesis, surface characterization, and in vitro biological assessments. Characterization methods include fourier transform infrared (FTIR), Zeta potential, X-ray diffraction (XRD), raman spectroscopy, ultraviolet-visible (UV-Vis) spectroscopy, and scanning electron microscopy (SEM). Results indicate that the DEAE-Dextran silver nanoparticle coating exhibits a uniform and stable layer on the titanium substrate, with significant antimicrobial activity against Staphylococcus aureus. The study concludes that DEAE-Dextran AgNPs-based coatings present a promising approach for enhancing the performance of titanium-based implants, offering a dual function of infection prevention and improved biocompatibility. This work contributes to the field of biomaterials by providing a novel coating strategy that combines the mechanical robustness of titanium with the biological functionalities of DEAEDextran and silver nanoparticles, potentially leading to improved clinical outcomes in orthopedic and dental implant applications. 30cm..

Place Hold on DEAE-Dextran silver nanoparticles-based biomimetic coating for titanium-based hard tissue implant applications /

ZnO Based Dental Restorative Materials and Support Membranes to Combat Diabetes Associated Oral Manifestations /

By Tanweer, Tahreem . . 234p. , Diabetes mellitus is a common metabolic disease characterized by sustained hyperglycemia. In diabetic patients, biofouling, microbial oral dysbiosis and chronic inflammation work together to create a powerful trifecta that makes it difficult for dental materials to effectively treat oral complications. This study aims to develop doped zinc oxide based dental restorative materials and support membranes to address diabetes associated oral complications i.e. caries and periodontitis. Silver, copper, and magnesium doped zinc oxide nanoparticles were synthesized via the coprecipitation method and characterized using scanning electron microscopy, energy-dispersive X-ray spectroscopy, fourier-transform infrared spectroscopy, and X-ray diffraction to assess structural, morphological, and chemical properties. The antibacterial potential of these NPs was tested against Streptococcus mutans using microbial assays. To explore doped Zinc oxide for caries management, zinc oxide and doped zinc oxide nanoparticles (1, 2.5, 5% w/w) were incorporated into commercial resin composite and tested for antibacterial activity against Streptococcus mutans, Enterococcus faecalis, and a normal and diabetic saliva microcosm. Key material properties such as aesthetics, compressive strength, depth of cure, pH response, and hemocompatibility were evaluated. The most promising formulation was tested in diabetic rodent model with secondary caries. For periodontitis management, a synthetic biodegradable support membrane incorporating selected doped zinc oxide was synthesized and characterized using scanning electron microscopy and fourier-transform infrared spectroscopy. Antibacterial efficacy was assessed against Streptococcus mutans, Enterococcus faecalis, and normal and diabetic saliva microcosms. Material properties such as tensile strength, swelling profile, and in vitro degradation were analyzed. The membrane’s bacterial adhesion was evaluated against Fusobacterium nucleatum, a major contributor to biofilm formation in diabetes-related oral conditions. Cell viability of h400 cells was assessed using trypan blue and calcein/propidium iodide assays, while antiinflammatory responses were evaluated by measuring interleukin-8 levels released by h400 cells after exposure to heat-killed F. nucleatum. In vivo testing was conducted on diabetic xi wistar rats with periodontal infection, examining lipid profiles, complete blood count, histology, and radiological findings over 54 days of treatment. Hexagonal silver doped zinc oxide, copper doped zinc oxide, and magnesium doped zinc oxide nanoparticles were prepared. Scanning electron microscopy analysis revealed simple zinc oxide nanoparticles with a uniform size of 23.6 nm, while doped nanoparticles had average sizes of 20.5 nm (silver doped zinc oxide), 39.56 nm (copper doped zinc oxide), and 22.37 ± 2.07 nm (magnesium doped zinc oxide). Antibacterial evaluation against Streptococcus mutans (initial count: 9.68 ± 0.02 log₁₀ CFU/mL) showed reductions to 9.603 ± 0.005 (zinc oxide, p = 0.0056), 9.3 ± 0.009 (silver doped zinc oxide, p < 0.0001), 9.207 ± 0.051 (copper doped zinc oxide, p = 0.002), and 9.43 ± 0.03 (magnesium doped zinc oxide, p = 0.0012) after 6 hours at 10 µg/mL. When incorporated into restorative composites, 2.5% w/w magnesium doped zinc oxide nanoparticles exhibited the best overall performance, showing superior antibacterial efficacy with mean bacterial counts reduced to 5.533 log₁₀ CFU/mL for Streptococcus mutans, 5.200 log₁₀ CFU/mL for Enterococcus faecalis, and 4.533 log₁₀ CFU/mL for diabetic saliva-derived microcosms (p < 0.0001 for all). The 2.5% magnesium doped zinc oxide composite also maintained significantly higher compressive strength (26.18 ± 0.67 MPa) compared to the pristine composite (22.84 ± 0.095 MPa, p < 0.0001), demonstrated stable pH elevation across immersion durations, and preserved acceptable aesthetics despite a statistically significant reduction in depth of cure (p = 0.0002). Furthermore, hemolysis percentages remained within safe limits (<5%), confirming biocompatibility according to ISO/TR 7406 standards. In the secondary caries assessment, 2 out of 3 rats in the pristine group and all 3 rats in the zinc oxide group exhibited carious lesions, whereas 0 out of 3 rats in the magnesium doped zinc oxide group showed any signs of secondary caries. For application in treatment of periodontitis, biodegradable polycaprolactone/sodium alginate/magnesium doped zinc oxide membranes were prepared that exhibited a thickness of approximately 145 ± 20 μm, with a smooth surface and visible aggregates indicating magnesium doped zinc oxide incorporation. Antibacterial testing revealed that xii polycaprolactone/sodium alginate/magnesium doped zinc oxide membrane showed the highest activity against Enterococcus faecalis (8.364 ± 0.05 log₁₀ CFU/mL), Streptococcus mutans (9.13 ± 0.06 log₁₀ CFU/mL), and normal saliva microcosm (7.9 ± 0.17 log₁₀ CFU/mL) compared to polycaprolactone/sodium alginate and polycaprolactone/sodium alginate/silver doped zinc oxide membranes. The ultimate tensile strength was highest in polycaprolactone/sodium alginate/magnesium doped zinc oxide (11.67 ± 0.19 MPa) compared to polycaprolactone/sodium alginate/ zinc oxide (9.94 ± 0.tact angle analysis showed that the addition of magnesium doped zinc oxide reduced the water contact angle to 48.3° ± 0.28, enhancing hydrophilicity compared to polycaprolactone/sodium alginate (55.36° ± 0.924). Moreover, polycaprolactone/sodium alginate/magnesium doped zinc oxide demonstrated an improved swelling capacity (25.1% ± 0.65) after 24 hours of immersion, higher than polycaprolactone/sodium alginate/zinc oxide (23.1% ± 1.37) and polycaprolactone/sodium alginate (17% ± 2.5). After 8 months, degradation analysis revealed the highest degradation in polycaprolactone/sodium alginate/magnesium doped zinc oxide (54.80%), compared to polycaprolactone/sodium alginate/ zinc oxide (44.15%) and polycaprolactone/sodium alginate (37.94%). Hemolysis assays confirmed the biocompatibility of all membranes, with hemolysis rates of 4.8 ± 0.11% for polycaprolactone/sodium alginate, 4.5 ± 0.25% for polycaprolactone/sodium alginate/silver doped zinc oxide, and 4.1 ± 0.21% for polycaprolactone/sodium alginate/magnesium doped zinc oxide, all remaining below the 5% safety limit. The study on diabetic wistar rat showed elevated triglyceride and low density lipopolysachride levels in the diabetic + periodontitis group, reflecting a dysregulated lipid profile associated with systemic inflammation. Treatment with the polycaprolactone/sodium alginate/magnesium doped zinc oxide membrane resulted in a statistically significant reduction in total cholesterol, triglycerides, and LDL levels. This improvement in lipid parameters was accompanied by a marked decrease in periodontal infection and inflammation. Radiological evaluations also showed visible signs of regeneration in treated rats. xiii The Fusobacterium nucleatum adhesion values varied significantly across the membranes, with polycaprolactone/sodium alginate showing a mean adhesion of 9.38% ± 5.18, while polycaprolactone/sodium alginate/magnesium doped zinc oxide exhibited the lowest mean adhesion of 0.7% ± 0.6. Cell viability testing showed untreated cells had 89.45% ± 2.051 viability, with polycaprolactone/sodium alginate, and polycaprolactone/sodium alginate/magnesium doped zinc oxide membranes resulting in 69.15%, 75.67%, and 76.90% viability, respectively. After 18 h of incubation, the control group having cells treated with health killed Fusobacterium nucleatum indicated a significant enhancement in CXCL8 levels (537 + 356 ng/mL). Both PCL/SA/ZnO and PCL/SA/MgZnO membranes were found to eliminate the release of CXCL8 in H400 cells following the same 18-hour exposure period.This study concludes that magnesium doped zinc oxide-based dental materials offer promising antibacterial and anti-inflammatory properties, along with enhanced mechanical strength, to address the oral health challenges associated with diabetes. In the future, these materials hold great potential for advancing dental care in high-risk populations such as diabetic patients. 30cm.

Place Hold on ZnO Based Dental Restorative Materials and Support Membranes to Combat Diabetes Associated Oral Manifestations /

Lipid based Nanoparticles for Wound Healing /

By Kazmi, Syeda Saira Haider. . 66p. , The rapid rise of antimicrobial resistance and the persistence of biofilm-associated infections present a critical challenge in wound care. Thymol, a natural monoterpenoid phenol, exhibits potent antibacterial and antibiofilm activity but suffers from low solubility, volatility, and poor stability, limiting its therapeutic application. In this study, thymolloaded nanostructured lipid carriers (T-NLCs) were developed using a solvent-free hot homogenization and sonication method.The formulations were comprehensively characterized by SEM, EDX, and FTIR,Zeta Potential and PDI confirming successful encapsulation of thymol and establishing strong drug–lipid interactions. Thymol loading reduced particle size and enhanced surface charge compared to empty NLCs, but increased heterogeneity. Antibacterial activity was evaluated against Staphylococcus aureus and Escherichia coli using agar well diffusion, biofilm inhibition, and time-kill kinetics. T-NLCs demonstrated significantly enhanced antibacterial effects compared to free thymol, with pH-responsive behavior amplifying their inhibitory zones under acidic conditions mimicking skin environments. Time-kill assays confirmed sustained bactericidal activity of T-NLCs, while biofilm inhibition studies revealed superior efficacy in reducing biomass formation for both Gram-positive and Gram-negative bacteria. Stability testing further demonstrated improved resistance of T-NLCs to phase separation and precipitation compared to free thymol. Overall, the findings establish thymol-loaded NLCs as a promising platform for wound infection management by combining improved stability, controlled release, and enhanced antimicrobial and antibiofilm activity. This eco-friendly, solvent-free nanocarrier system offers translational potential for topical wound care applications and provides a sustainable strategy to reduce reliance on conventional antibiotics. 30cm.

Place Hold on Lipid based Nanoparticles for Wound Healing /

Complex Materialsfor Skin Diseases /

By Riaz, Aqsa . . 65p. , For the development of complex multifunctional materials as advanced wound dressings for the treatment of skin diseases, particularly chronic and infected wounds. By integrating cerium oxide nanoparticles and thymol-based deep eutectic solvent hydrogels into a chitosan-gelatin matrix, the study addresses pressing challenges in wound care, including antimicrobial resistance, limited drug stability, and poor localization at wound sites. Engineered hydrogels provide sustained release of active compounds, effectively disrupt biofilms from resistant bacteria such as Staphylococcus aureus and Escherichia coli, and deliver combined antimicrobial, antioxidant, and antiinflammatory effects. Laboratory evaluations demonstrated significant antibacterial activity, enhanced biofilm inhibition, and improved healing potential compared to conventional therapies. The results establish these materials as strong candidates for next generation wound dressings, with future research focused on optimizing formulation stability and validating in vivo safety. This work contributes to advancements in wound management by offering promising solutions for minimizing antimicrobial resistance and enhancing healing outcomes in chronic skin infections. 30cm.

Place Hold on Complex Materialsfor Skin Diseases /