NUST Institutions Library Catalogue Search for 'kw,wrdl: (su-br:"Drug Design.")'

Biosensors (E-Book)

By Pier Andrea Serra. India In-Teh 2010 . viii,302 P;

Mathematical Models in Biology an introduction

UK Cambridge University press 2004 . 370 p. 0-521-61555-0

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Oral Administration of Fluoxetine Incorporated Liposomal Nanoparticles coated with PEG in Treatment of Chronic Mild stress (CMS) /

By Sadiq, Nadia . . 55p. , Depression is one of the most increasing psychological mood disorders, depression does not have some specific physical symptoms, but it negatively affects the person mood, way of living and thinking chronic mild stress (CMS) is one of its type, depression is affecting more than 300million people in the world. Shortness of breath, headache, being miserable, stomach disturbance and physical tensions are some of the common symptoms of depression that is reported according to National Alliance of Mental Health, Anti-depressant are used for altering the neurotransmitters those are serotonin, dopamine and norepinephrine that are primarily involved in regulating and mood alleviating mood. Despite the availability of large number of drugs, many of patients are resistant to the current mode of treatment that are available now adays. The obstacle that is significant for the transportation of beneficial therapeutic entities to the nervous system is BBB that is the blood brain barrier. There are junctions that are present in the endothelial cells of the blood brain barrier that stop the drugs passage. Now nanoparticles are receiving significant limelight owing to their small size and efficient brain targeting activity, making them likely to cross the blood brain barrier while carrying the intact drug molecule otherwise incapable of permeation. In this study the fluoxetine loaded liposomal nanoparticle coated with PEG were developed to transport the drug across the BBB to the central nervous system having much greater efficiency. For testing its delivery, the animal that is mice model of depression is used with the specific name that is designed in order to induce depression like symptoms in mice. Before and After treatment great differences between the physical behaviors like Elevated maze, open field test, force swim test etc and sucrose consumption test were identified and plotted, as liposomes that having capabilities to carry the anti-depressant drug molecule that is administered through the Oral route of administration or the better and improved method of treatment. 30cm.

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Nelson essentials of pediatrics /

. xv, 829 pages; 29 cm.. 9780323775632 | 9780323775625

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Advanced nanocarriers for skin diseases /

By Khan, Rida Khalid. . 68p. , The development and evaluation of an advanced nanocarrier hydrogel system designed to address the major barriers in diabetic wound healing, specifically targeting chronic inflammation, oxidative stress, bacterial infection, and impaired angiogenesis. This therapeutic system integrates cerium oxide nanoparticles (CeO₂), metal-organic frameworks (MOFs), and a chitosan-gelatin hydrogel platform to create a multifunctional wound dressing. CeO₂ nanoparticles provide strong antioxidant and antibacterial activity, MOFs enable controlled drug release and add antimicrobial properties, while the chitosan-gelatin hydrogel ensures biocompatibility, moisture retention, and accelerated tissue repair. Comprehensive characterization, including Raman spectroscopy, FTIR, UV-Vis, EDX analysis, and optical microscopy, confirmed successful synthesis, structural integrity, and the presence of desired functional groups. Biological assays demonstrated superior antibacterial and antibiofilm performance of the CeZn-Gel composite against E. coli and S. aureus, surpassing individual system components and controls. The integrated approach not only enhances wound healing outcomes but also reduces infection and inflammation, with significant potential for improving patient quality of life in chronic wound care. Future work will focus on optimizing formulation and advancing toward clinical testing for broader therapeutic impact. 30cm.

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