NUST Institutions Library Catalogue Search for 'kw,wrdl: (su-br:"Models, Neurological.")'

Recent Advances in Biomedical Engineering (E-Book)

By Dr Ganesh R Naik. India In-Teh 2009 . xii,660 P;

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Characterization of the Role of Neurexin-1 in MPTP Induced Parkinsonism in Mice Model /

By Naeem, Mahnoor . . 62p. 30cm.

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Characterization of atrial natriuretic peptide (ANP) response in depression-induced mice models /

By Ali, Saman . . 71p. , Depression is a complex psychological disorder that is also often link to the hormonal imbalances. Our research delves into the intricate relationship between depression and atrial Natriuretic Peptide (ANP), considering the multifaceted influences of neurological, genetic, and environmental factors. With a focus on hormonal imbalances as key contributors to depression, our investigation explores the potential therapeutic effects of Levothyroxine (LT4) in the context of ANP. Utilizing an early weaning mouse model involving maternal separation, we conducted a detailed examination of the anxiolytic effects of LT4, aiming to evaluate its efficacy in alleviating symptoms associated with anxiety and depression. Behavioral assessments and histological analyses were employed to comprehensively evaluate the impact of LT4 on ANP. This study also extends to molecular investigations using RT-PCR to analyze the distribution and expression of ANP within the mouse central nervous system, highlighting the cortex region. Our findings reveal significant differences in brain expression levels of ANP between treated mice and those exhibiting depressive symptoms. This insight suggests potential therapeutic applications of ANP for mitigating depression, presenting intriguing avenues for further research, particularly in the context of depression-induced mouse models through parental separation. This research contributes to an enriched understanding of the complex factors influencing depression and proposes interventions that extend beyond conventional approaches. The integration of behavioral assessments, histological analyses, and molecular investigations offers a holistic perspective, laying the groundwork for future exploration in the critical realm of mental health research. 30cm.

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Investigating Chrysoeriol-Mediated Protection in MPTP-Induced Mouse Model of Parkinson's Disease /

By Ali ,Mehak. . 105p. ; , Parkinson's disease (PD) is a neurodegenerative condition characterized by the progressive loss of dopamine-producing neurons in the substantia nigra pars compacta, which results in severe motor impairments. While the precise cause of PD remains unknown, research indicates that factors such as oxidative stress, mitochondrial dysfunction, and the triggering of apoptotic pathways play key roles in the degeneration of these neurons. Current treatments focus on stabilizing dopamine levels but do not halt disease progression. Therefore, exploring compounds that can mitigate apoptotic neuronal loss is promising for therapy. Chrysoeriol, a 3’-O-methoxy flavone and luteolin derivative, is known for its anti-cancer, anti-diabetic, antioxidant, anti-inflammatory, and neuroprotective properties. Despite extensive research, its effect on PD mouse models is still unclear. This study examines the neuroprotective effects of 5 mg/kg of Chrysoeriol administered intraperitoneally for 14 days in an in vivo sub-acute PD model, established using 20 mg/kg MPTP administered via intraperitoneal injections at two-hour intervals for a total of four doses in one day. Behavioral tests, including the Pole test, Y-maze test, forced swim test, and tail suspension test, showed significant recovery from PD-induced neurological deficits in Chrysoeriol-treated mice. Hematoxylin and Eosin staining confirmed reduced neuronal damage in Chrysoeriol-treated mice in different areas of the brain, including the midbrain, cerebellum, cortex, and hippocampus. qPCR analysis was used to detect the relative expression of α-Synuclein, Bcl-2 (anti-apoptotic) and Bax (pro-apoptotic) proteins. The levels of α-synuclein, a major protein implicated in PD pathology, were significantly downregulated in the treatment group compared to the diseased group, indicating that Chrysoeriol plays a role in the downregulation of α-synuclein. Moreover, in the diseased group, Bax levels were up-regulated, and Bcl-2 levels were downregulated, reducing the Bcl-2/Bax ratio. Chrysoeriol treatment significantly reversed this downregulation. Our results demonstrated that Chrysoeriol treatment significantly reduced MPP+- induced toxicity, downregulated α-synuclein expression levels, and improved Bcl-2/Bax ratio expression levels in in vivo mouse models. Our research indicates that Chrysoeriol offers protection against MPP+-induced apoptosis in mice by activating the PI3K/Akt signaling pathway. This finding suggests that Chrysoeriol could be a promising therapeutic option for PD. 30cm..

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Algorithms in advanced artificial intelligence /

New Yprk CRC Press 2024 . xxiii,520 Pages.; 9781032867984

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