NUST Institutions Library Catalogue Search for 'kw,wrdl: su-br:an:"119503"'

Isolation, Phytochemical Analysis and Antibacterial Activity of Rumex acetosella Plant /

By Abbasi, Zoya Orangzeb . . 62p. 30cm.

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Saikosaponin B2 modulate oxidative stress in scopolamine induced murine model of Alzheimer’s Disease /

By Malik, Mehreen Nadeem . . 80p. , One of the initial pathological hallmarks of Alzheimer's disease is cognitive decline and memory loss by disruption of cholinergic neurons and oxidative brain damage. A postsynaptic muscarinic receptor blocker, scopolamine impairs cholinergic transmission and impairs cognition. Here, we observed the physiological processes underlying Saikosaponin b2's impact on memory deficits in mice that had been given scopolamine repeatedly. Scopolamine (1 mg/kg) administration for 15 days caused severe deficits in working and short-term memory in mice, as determined by the elevated plus maze, Morris water maze, and novel object recognition tests. However, scopolamine administered mice who were additionally given Saikosaponin b2 did not experience either deficit. This effect was associated with an increase in antioxidant enzymes (superoxide dismutase, Glutathione reductase, glutathione s transferase and catalase), followed by reduction in lipid peroxidation and myeloperoxidase activity. 30cm.

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Green Synthesized Silver Nanoparticles Enhances Anticancer Activity of HDAC Inhibitor Panobinostat /

By Nawaz, Tayyaba . . 80p. , Breast cancer is the most common cancer among women even though numerous treatment options for breast cancer have been documented. Panobinostat, A histone deacetylase inhibitor, modifies gene expression through epigenetic pathways and prevents protein breakdown. The focus of this study is to enhance drug distribution to the tumor site and boost the efficiency of Panobinostat by using silver nanoparticles as controlled drug delivery system. Here we report the green synthesis of silver nanoparticles by using Rhazya stricta extract, as a nanocarriers for drug delivery. These drugs loaded nanoparticles were characterized by UV-Vis spectroscopy, XRD, FTIR, SEM, and EDX techniques. The overall findings demonstrated that AgNPs synthesized through Rhazya stricta has the high potential for sustained release of Panobinostat for cancer therapy. As the successfully synthesized Panobinostat-AgNPs were stable and exhibited increased in vitro anticancer activity compared with free Panobinostat, our data demonstrate that the combination of AgNPs with Panobinostat improves the drug's longterm viability, effectiveness, and active targeting as a potential targeted therapeutic molecule for the treatment of cancer. To strengthen the utilization of this combination therapy in cancer therapy trials, further research is warranted. 30cm.

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Liposomal Formulation of Lapatinib for the Treatment of Breast Cancer /

By Idrees, Maria . . 70p. , Breast cancer is the most common type of cancer among global women, even though numerous treatment options for breast cancer have been documented. Lapatinib, a tyrosine kinase inhibitor, modifies the cellular pathways and halts cell proliferation. The focus of this study includes the distribution of the drug to the tumor site in high amount and boost the efficiency of Lapatinib-loaded liposomes as a controlled drug delivery system against breast cancer. The synthesis of liposomes was followed by drug loading. The cargo was characterized under XRD, FTIR, SEM, EDX, and zeta analysis techniques. The overall findings demonstrated that the Liposomal formulation of Lapatinib has a high potential for sustained release of the drug for cancer therapy. As the successfully synthesized Lapatinibliposomes were stable and exhibited increased in vitro anticancer activity as compared to free Lapatinib. Our study demonstrates that the combination of Lapatinib with liposomes improves the drug's long-term viability, effectiveness, and active targeting as a potential targeted therapeutic molecule for breast cancer treatment. To strengthen the utilization of this combination therapy in cancer therapy trials, further research is warranted. 30cm.

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Endocrine Dysregulation Adversely Effects Female Reproductive Health in South Punjab Pakistan /

By Rao, Marium Tufail . . 101p. , Endocrine disorders have severe consequences for reproductive health and, overall, the woman’s condition. The role of this research is to establish the level of hormonal imbalance resulting in reproductive and other diseases among women in south Punjab, Pakistan. Thus, the present study has adopted a cross-sectional, observational research design in choosing 430 females from Bahawalpur Victoria hospital. Serum samples were also taken from females and hormonal assays performed on the collected samples in endocrine lab. The collected data were analyzed statistically to compare hormonal levels with health status of the women. The findings of the study were that the common symptoms were fatigue, cravings for food, and the high level of obesity among the participants. Hormonal level was correlated with amenorrhea, oligomenorrhea, type 2 diabetes, and insomnia at the considerable level. Serum levels of CA- 125 and AFP were also raised significantly with ovarian cancer. Some other common manifestations were psychological, such as depression, anxiety, increased, and insomnia. Also, the most frequent reproductive symptoms identified were pain and swelling of the breasts, benign breast diseases, and night sweating. The survey work showed high prevalence of hair loss and hirsutism to above the norms, therefore pointing at dermatological consequences of hormonal disturbances. Another group of marriage-related problems that were also identified were fertility problems which were also common affecting a large percentage of the population. No significant associations were found between hormonal levels and certain conditions such as cardiovascular disease and liver disease. The hormonal testing showed dysregulation in FSH and LH and estrogen and progesterone and thyroid hormones. Women of south Punjab are undergoing hormonal imbalance, which includes reproductive health problems and other health related concerns. Focused education on symptoms, early checkups, and encompassing medical approaches are useful in reducing effects of hormonal fluctuations in this group of ladies. 30cm.

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pH-Responsive Aloe Vera Hydrogels Loaded with Imatinib for Targeting Drug Resistance in Cancer /

By Hasan Khan ,Aroob. . 77p. ; , Cancer and its reoccurrence have become a major health problem affecting the quality of life for millions of individuals every year. The currently available strategies, radiotherapy, and chemotherapy have non-specific targets, lower solubility, and severe side effects. Hydrogels are crosslinked polymeric networks with higher swelling properties, degradation, biocompatibility, and flexibility which can be manipulated based on the desired application. Incorporating AV can elevate the antioxidant, and anticancer properties of the hydrogel based drug delivery system (DDS) also warranting enhanced swelling, drug release, and environmental degradability of the system. Acrylic acid (AA) induces pH-responsive properties in the hydrogels. The PVA/SA and PVA/SA/AV hydrogels were synthesized with a pH responsive behavior and investigated at different pH conditions. The unloaded and loaded PVA/SA and PVA/SA/AV hydrogels with imatinib (IM) were characterized for their structural morphology, physiochemical characteristics, and antioxidant and anticancer activity. The IM loaded PVA/SA/AV hydrogels showed increased pore size in SEM micrographs, enhanced swelling abilities up to 400%, 100% degradation, 56% encapsulation efficiency, and drug release profiles of up to 94% in 24 h, compared to PVA/SA hydrogels loaded with IM. Dpph radical scavenging activity was also observed to be enhanced in PVA/SA/AV hydrogels. Finally, the cell viability analysis in resistant MCF-7 breast cancer cell lines exhibited 41% cell viability of the PVA/SA/AV hydrogels loaded with IM implying a promising potential of AV to be incorporated in a hydrogel based drug delivery system for targeting drug resistance in cancer. 30cm..

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