NUST Institutions Library Catalogue Search for 'kw,wrdl: su-br:an:"1290"'

Therapeutic Potential of Light Flicker for Schizophrenia - A Comparative Study

By Ihsan ,Faryal. . 93p. ; , Schizophrenia is a serious neuropsychiatric condition that affects cognition, perception, and behavior. Current pharmacological treatments are successful in treating symptoms but can have serious adverse effects, especially in susceptible populations such as children and the elderly. These negative consequences, which range from metabolic problems to cognitive impairment, underline the critical need for alternate, non-invasive therapeutic techniques. One promising approach is neuromodulation by gamma entrainment with sensory stimulation, which uses an external stimulus to restore broken neuronal synchronization. This study looks at the combined effects of Clozapine and light flicker therapy in a ketamine-induced schizophrenia mouse model, with the hypothesis that their synergistic action will lead to improved recovery. Mice were classified into five groups: control, diseased, Clozapine-treated, light flicker-treated, and combination therapy. Behavioral examinations, such as the open field test, elevated plus maze, forced swim test, tail suspension test, novel object recognition, and Y-maze, demonstrated that combination therapy improved cognitive and affective deficiencies the most significantly. Histological analysis with hematoxylin and eosin staining of the cortex and hippocampus (CA1 and CA3) revealed severe neuronal disorganization in the diseased group, partial restoration in the individual treatment groups, and near-control level preservation in the combination therapy group. RT-PCR analysis using Pvalb and BDNF primers indicated abnormalities in PV interneurons and neuroplasticity markers, which corroborated the histological and behavioral findings. Our approach to schizophrenia combines neuroscience and psychology. Restoring gamma oscillations with light flicker improves PV interneuron function, BDNF production, and cognitive stability. This neuronal synchronization minimizes ego fragmentation, improves self perception, and promotes cognitive integration for a more comprehensive treatment. 30cm..

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ENHANCED NOVEL VIEW SYTHESIS VIA DEEP LEARNING-BASED 3D GAUSSIAN SPLATTING /

By Ullah Noor, Zabeeh . . 83p. ; , 3D Gaussian Splatting (3DGS) has emerged as a breakthrough in explicit radiance fields and computer graphics which has enabled precise scene representation, real time rendering, and efficient novel view synthesis. This paper explores the evolution of 3D rendering and recent advancements in 3DGS, with a particular focus on different techniques for synthesizing novel views with the incorporation of deep learning architectures especially transformers. To enhance scene quality, this research investigates the integration of monocular depth information during rendering and refines the loss function to improve reconstruction accuracy. By incorporating depth information our method enhances geometric details by capturing intricate details and reduction of artifacts. The findings contribute to the reconstruction of 3D scene with high fidelity, offering insights to optimize Gaussian Splatting technique for more efficient and realistic 3D rendering applications. 30cm..

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Bridging AI and Psychiatry: Comparative Insights from Transformer Models for Depression Diagnosis and Treatment/

By Shahnawaz Zahra .

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