NUST Institutions Library Catalogue Search for 'kw,wrdl: su-br:an:"425"'

Production Management Systems : An Integrated Perspective /

By Browne, Jimmie.. Harlow, England ; | Reading, Mass. : Addison-Wesley Pub. Co., 1996 . xxiv, 425 p. : 24 cm.. 0201422972 (alk. paper)

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A brief introduction to circuit analysis /

By Irwin, J. David,. Hoboken, NJ : Wiley, 2008 . xviii, 425 p. : , Includes a supplement : "Chapter 9, Steady-state power analysis to accompany a brief introduction to circuit analysis" (45 p.). | Includes index. 26 cm.. 0471455466

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Mobile Computing /

By Tomasz Imielinski. London Kluwer Academic Publishers 1996 . xxii,728p.

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Biomedical Engineering (E-Book)

By Carlos Alexandre Barros de Mello. India In-Teh 2009 . x,658 P;

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Career Planning for the 21st Century :

By McGraw-Hill.. [S.l.] : Glencoe/McGraw-Hill, 1999 . 222p. ; , Paperback. 27 cm.. 0314129936 | 9780314129932

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Popular English Grammar and Composition With a Textbook Supplement

By Prof. Sh. Karim-ud-Din. Lahore, Pakistan Mukhtar Brothers 1994 . 663

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Prediction versus performance in geotechnical engineering : proceedings of the symposium on prediction versus performance in geotechnical engineering, Bangkok, 30 November-4 December 1992 /

Rotterdam ; | Brookfield, VT : A.A. Balkema, 1994 . ix, 341 p. : , Proceedings of the annual Geotechnical Symposium sponsored by the Asian Institue of Technology and the Southeast Asian Geotechnical Society. 26 cm.. 9054103558

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Basic soil mechanics /

By Whitlow, R.. Harlow, Essex, England : | New York : Longman Scientific & Technical ; | Wiley, 1995 . xxi, 559 p. : 24 cm.. 0470234997 (Wiley) | 0582236312

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Bridges : Analysis, Design, Structural Health Monitoring, and Rehabilitation /

By Bakht, Baidar,. . 1 online resource (XV, 425 pages 325 illustrations, 79 illustrations in color.) 9783319178431

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Schwartz's Principles of Surgery /

New York : McGraw-Hill Education, 2019 . volume; 28 cm.. 9781259835353

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Browse's Introduction to The Symptoms and Signs of Surgical Disease /

Boca Raton : CRC Press Taylor & Francis Group, 2021 . 644 p. ; 25 cm.. 9780367246952

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Critical psychology praxis : psychosocial non-alignment to modernity/coloniality /

. pages cm. 9780367635640 | 9780367634636

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Media voice space and power : essays in refraction /

By Couldry, Nick,. . pages cm 9780367182052 | 9780367182069

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Characterization of atrial natriuretic peptide (ANP) response in depression-induced mice models /

By Ali, Saman . . 71p. , Depression is a complex psychological disorder that is also often link to the hormonal imbalances. Our research delves into the intricate relationship between depression and atrial Natriuretic Peptide (ANP), considering the multifaceted influences of neurological, genetic, and environmental factors. With a focus on hormonal imbalances as key contributors to depression, our investigation explores the potential therapeutic effects of Levothyroxine (LT4) in the context of ANP. Utilizing an early weaning mouse model involving maternal separation, we conducted a detailed examination of the anxiolytic effects of LT4, aiming to evaluate its efficacy in alleviating symptoms associated with anxiety and depression. Behavioral assessments and histological analyses were employed to comprehensively evaluate the impact of LT4 on ANP. This study also extends to molecular investigations using RT-PCR to analyze the distribution and expression of ANP within the mouse central nervous system, highlighting the cortex region. Our findings reveal significant differences in brain expression levels of ANP between treated mice and those exhibiting depressive symptoms. This insight suggests potential therapeutic applications of ANP for mitigating depression, presenting intriguing avenues for further research, particularly in the context of depression-induced mouse models through parental separation. This research contributes to an enriched understanding of the complex factors influencing depression and proposes interventions that extend beyond conventional approaches. The integration of behavioral assessments, histological analyses, and molecular investigations offers a holistic perspective, laying the groundwork for future exploration in the critical realm of mental health research. 30cm.

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Therapeutic Potential of Galantamine for Managing the Complications Associated with Ischemic Stroke /

By Ahsan, Mehwish . . 104p. , Ischemic stroke remains the leading cause of illness and second leading cause of death worldwide. Previous research has shown that galantamine has neuroprotective properties, reducing neuronal death and damage in neurodegenerative conditions and improving cognitive function in Alzheimer's disease patients. The investigation looked into the possible mechanisms by which this medication could reduce cell death. Wistar rats were subjected to a temporary 30-minute occlusion of the right middle cerebral artery (MCA) and given an oral dose of 5mg/kg for three weeks. After 18 days of surgery, behavioral assessments were carried out. Galantamine enhanced grip strength, motor function, and muscle strength in rats. Spatial memory and object recognition examinations revealed cognitive improvements, thus indicating enhanced cognitive abilities and memory retention. Moreover, rats subjected to galantamine treatment displayed increased sociability and heightened locomotor activity during social interaction and open-field assessments. Molecular analysis of galantamine treatment in rats showed an upregulation of SOD2 expression, suggesting enhanced antioxidant defense, and a downregulation of TLR4 expression, suggesting a reduction in neuroinflammation, supporting the anti-inflammatory properties of galantamine. The histological analysis done with H&E staining of brain tissue revealed enhanced tissue morphology in the galantamine-treated group, signifying the neuroprotective effects of galantamine. The reduction in neuronal damage, edema, and inflammatory cell infiltration further supported this observation. The results demonstrate that galantamine, potentially through the preservation of a functional cholinergic system, mitigated the impairments caused by stroke in a basic learning and memory test by decreasing cellular death. 30cm.

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Effectivity of Rutin-bound Carbon dots in preventing the aggregation of Amyloid beta /

By Noor Afza. . 78p. , According to the World Health Organization up to 55 million people have dementia resulting in concerning socio-economic implications. About 60-80% cases of dementia are associated with Alzheimer's disease. With all the advances in medicine, there still is no cure. Blood-brain barrier monitors the entry and exit of nutrients and molecules which makes it difficult for various drugs and therapeutic molecules to cross it. Carbon dots are made from glucose to overcome the BBB. Rutin is a naturally existing flavonoid extracted from plants and has therapeutic effects in neuroprotection. This study aims to improve the effectiveness of rutin combined with targeted delivery of carbon dots. Carbon dots were loaded with Rutin to make CD-Rutin, a nano-sized combination with a targeted drug. FTIR, UV-IR, and SEM analysis have produced positive results regarding the doping of CDs with Rutin. Administration of CD-Rutin was done in AD-like rat models at eight to twelve months of age. Alzheimer's was induced in rats with Aluminum Chloride and D-galactose through IP administration for two weeks. Behavioral tests were performed to check the progression of the disease. In silico analysis was also done to check ligand-protein interaction to check variation in the binding of Aβ isoforms with Rutin. Afterward, a single injection of CD-Rutin (10 mg/kg) was given intraperitoneally as well. Behavioral testing was done after the administration of the drug. Characterization techniques revealed the successful formation of CDs and subsequent loading of Rutin onto the CDs resulting in a CD-Rutin combination. In silico analysis provided strong binding affinities of Rutin with Aβ isoforms affirming Rutin as a favorable treatment to target amyloid aggregates. 3D configuration showed binding of Rutin with hydrophobic domains of protein oligomers Behavioral testing provided significant difference in the treated group with better memory retention and performance in activities involved in behavioral testing. After behavioral testing, rats were dissected for molecular analysis including H&E to assess cell degeneration and Thioflavin T staining to assess amyloid aggregates in the brain tissues. Results provided positive data in terms of cell count in the cortex. Overall results suggest that memory impairment and cognitive abilities were significantly improved after injections. The results demonstrate the positive therapeutic potential of CD-Rutin in Alzheimer's treatment. 30cm.

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Therapeutic Potential of Rivastigmine for Managing Complications Associated with Ischemic Stroke /

By Abbasi, Irum Naeem . . 80p. , Stroke continues to be the world’s primary cause of morbidity and mortality, frequently with incapacitating consequences like movement dysfunction, cognitive decline, and neurological impairments. It is essential to manage stroke effectively to lessen its negative effects and enhance patient outcomes. The potential neuroprotective benefits of acetylcholinesterase inhibitors may assist maintain the integrity of brain tissue and lessen the damage that neurons may sustain after a stroke, making them a promising option in this situation. This comprehensive thesis explores the neuroprotective benefits of an acetylcholinesterase inhibitor, Rivastigmine, in relation to stroke outcomes in a variety of ways. Using an advanced integrative methodology, this study includes behavioral evaluations, in silico analysis, histopathological results, and molecular studies to give a comprehensive picture of the possible mechanisms behind therapeutic effects of Rivastigmine. Within the field of computer modelling, the docking interactions between SOD2 and TLR4, the target proteins of Rivastigmine, provide detailed structural information that directs further experimental validations. Following Rivastigmine treatment, the behavioral tests conducted exhibited improvements in cognitive, motor, and social domains. These results were further corroborated by histopathological analysis, which shows neuroprotective effects in Rivastigmine treated group as opposed to surgery (MCAO) group. Post Rivastigmine treatment, real-time PCR data showed a rise in SOD2 and a decrease in TLR4 levels in surgery (MCAO) rats, exhibiting antioxidant and anti-inflammatory effects of Rivastigmine. These findings provide interesting directions for future neuroprotective approaches and shed light on the possible therapeutic implications of Rivastigmine in reducing neurodegeneration that occurs in stroke. 30cm.

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