NUST Institutions Library Catalogue Search for 'kw,wrdl: su-br:an:"6090"'

Nanomanufacturing handbook /

By Busnaina, Ahmed. Boca Raton, FL : CRC Press/Taylor & Francis, 2007 . 408 p. : , Includes Index http://www.amazon.com/Nanomanufacturing-Handbook-Ahmed-Busnaina/dp/0849333261/ref=sr_1_1?s=books&ie=UTF8&qid=1412244080&sr=1-1&keywords=0849333261 25 cm.. 9780849333262 (alk. paper) | 0849333261

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Design and Development of a System for Pressure Measurement in Patients using Lower Limb Prosthetic and Orthotic Appliances /

By Javaid, Ajla . . 68p. , Pain and pressure sensation as parts of somatosensory system provides sense of awareness of joint position & body orientation in space. Proprioception works like a constant feedback loop where human beings are very well aware of body position and forces acting on it. Any abnormality in pressure especially for amputees would result in skin break down, joint disorders and noncompliance of prosthetic limb. In order to avoid problems related to skin & joints along with psychological satisfaction of patient, pressure mapping is performed with improved device compliance. Due to unavailability and high cost of MEMS based bubble sensors and TEKSCAN system, an effective and low-cost solution to problems related to pressure mapping before and after prosthetic fittings is introduced wherein a device capable of being incorporated within stump and prosthesis with minimal chances of breakage due to its flexibility is designed. Twelve pressure tolerant & sensitive areas of stump were marked upon silicon-based stump liner of 3mm thickness for TTP socket. FSR are attached to those specified areas and a Bluetooth module is used in PCB to send data through PLX-DAQ into MS-Excel. When a patient wears his/her prosthesis along with specially designed silicon liner having FSR and bears weight or walk, data is sent back into excel sheet recording the pressure values from 12 locations of a stump. Then adjustments can be made in prosthesis on the exact locations that showed increased pressure values so to eliminate pain and pinch and relieve the patient. Data from 7 patients during standing/ loading response of gait cycle was taken at Rehabilitation department of hospitals and required adjustments were made in prosthetic socket and alignment by the clinician/prosthetist. Comparison between means of pressure values before (27N/m2 ) and after making adjustment in prosthesis was made which showed improved values of pressure on distal tibia (<17N/m2 ) Data from 1 patient was obtained through all phases of his gait cycle and plotted on MS-Excel to find out exact phase of gait cycle causing more pressure on stump. The results showed significantly increased values of pressure on sensitive regions of stump during mid-stance phases of gait cycle (>75N/m2 ). While during early stance and swing phases the pressure values were significantly low (<28.7N/m2 30cm.

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Study the effect of shallow cryogenic treatment on mechanical and microstructural properties of 30CrMnSiA steel heat treated in vacuum furnace and Box Type conventional air furnace /

By Aslam, Muhammad Danyal . . 50p. , Heat treatment plays a major role in improving the material properties. With the addition of cryogenic treatment these properties can be further improved. In this paper heat treatment is carried out on low carbon low alloy structural steel in two different types of furnaces conventional box type air furnace and vacuum furnace along with shallow cryogenic treatment with the purpose to investigate the outcome of shallow cryogenic treatment on the material properties and to find out which type of furnace is more suitable with shallow cryogenic treatment. For this purpose, structural steel 30CrMnSiA was selected, and heat treatment was carried out in conventional box type air furnace (900°C × 40mins) and vacuum furnaces (900°C × 70mins), shallow cryogenic treatment (-75°C × 125mins) was carried out after the quenching and before tempering. For the physical properties of the material, hardness (HRC) was investigated using Brinell hardness tester HBD-62-5AP. Tensile samples were prepared as per ASTM E8/E8M and investigated using 100kN WAW-100B Electro-Hydraulic Servo Computer Control Universal Testing Machine. Impact toughness was measured by using electronic pendulum impact testing machine CBD-300 and specimens were prepared using ASTM standard E23-12c. Microstructural analysis for grain structure was carried out using Olympus DSX1000 optical microscope. 30cm.

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COVID-19 (6LU7) predictive binding association with Aβ oligomers and possible link to Alzheimer's disease /

By Khan, Areej Sohail . . 74p. , The high rise pandemic of Coronavirus Disease 2019 (COVID-19) makes the world face medical challenges associated with multifaceted nature of its pathology. SARSCoV-2 affects several organs and systems as it enters the host’s body one of which is the brain. Over 80 million humans around the globe, including those with neurodegenerative disease (NDD), have been diagnosed with coronavirus disease 2019 (COVID-19) to date. COVID-19 affects the brain in many ways including direct infection of neural cells with SARS-CoV-2, severe systemic inflammation that floods the brain with pro-inflammatory agents leading to damaging cells and leading to symptoms presenting cognitive impairment. COVID-19 positive patients showcase neurological symptoms leading to the belief that coronavirus disease plays a role in neurodegenerative diseases. The most common NDD, Alzheimer’s disease (AD) is characterized by its multifactorial nature leading to research on risk factors that emphasizes on the inflammation of toxicity and mutual death of cells due to amyloid beta and its conformers, namely monomeric and oligomeric forms. Amyloid beta oligomers initiate toxicity and neural death of cells in AD. The main aim of this study is to decipher the interactive association between toxic forms of amyloid beta oligomer against COVID-19 main protease. We used PDB and Pubchem for library retrieval that was loaded in to discovery studio to extract the active binding site of main protease of SARS-CoV-2 and prepare ligands for docking. Furthermore, we utilized PyRx for docking to investigating binding energies of conformations attained, the best affinity ligands were formed into a complex by the use of Pymol that were than visualized using Discovery studio where 2D interactions were also observed that later were further analyzed using Ligplot+ to get an insight on bond length and strength along with bond types. Aβ oligomer 31-35 binds actively to the active site of M-pro of SARS-CoV-2 at a high affinity rate of -6.3kcal/mol. 6LU7 complex with amyloid 31-35 (Complex 1) when docked XII with the receptor of apoptotic pathway showed enhanced predictive association. Bioinformatics tools in this research substantiated the important interactive partners amongst amyloid oligomers to COVID-19 highlighting that SARS-Cov-2 may play a role in apoptotic demise of cells ultimately leading to neurodegeneration. 30cm.

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Development of High-Resolution Imaging System for Blood Activity Monitoring /

By Qasim, Syed Muhammad Ali . . 46p. , fNIRS is a non-invasive, portable & easy to use brain imaging modality. It can estimate the hemodynamic response of the brain by measuring the absorption of IR light with respect to time. The standard channel separation between source & detector in fNIRS is 3cm but this distance has a disadvantage of higher channel noise. To resolve the issue, we have presented a new fNIRS design with small channel separation to minimize the channel noise. In this research, we have designed the fNIRS device using 2 sources & 14 detectors in a circular configuration. The detectors are placed in two circles each circle having 7 LEDs with a radius of 1.5cm & 2.25cm respectively. After the software design, we implemented it on a hardware & tested the device using occlusion. Once the device got tested through occlusion, we acquired the brain signals by placing it on the left frontal cortex. After placing the device on the frontal cortex, we reverse counted for 200sec with rest & count intervals. The whole experimental design is described in the sections below. We applied Modified Beer Lambert Law (MBLL) to deduce results. The results proved to be promising as the channel noise reduced & we got better signals. The results can be improved further by using the high-power IR LEDs having better penetrating ability 30cm.

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Stream Classification & Brand Recognition for Media Analysis /

By Ijaz, M Adeel . . 55p. 30cm.

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