NUST Institutions Library Catalogue Search for '(su:"MS Biomedical Sciences BMS ")'

SAIKOSAPONIN B3 PROTECTS AGAINST MPTP-INDUCED PARKINSON'S DISEASE BY PREVENTING MITOCHONDRIAL OXIDATIVE DAMAGE /

By Shahzadi,Neelam . Islamabad : SMME - NUST, 2016 . 57 P. : ill. ; , Hardcover, 30cm..

Place Hold on SAIKOSAPONIN B3 PROTECTS AGAINST MPTP-INDUCED PARKINSON'S DISEASE BY PREVENTING MITOCHONDRIAL OXIDATIVE DAMAGE /

Doxorubicin & Disulfiram-metabolite Loaded Nanocarriers for The Effective Combination Therapy Against Acute Myeloid Leukaemia /

By Tariq, Urooba . . 150p. 30cm.

Place Hold on Doxorubicin & Disulfiram-metabolite Loaded Nanocarriers for The Effective Combination Therapy Against Acute Myeloid Leukaemia /

Nanoencapsulation of Ferrocene Incorporated Thiourea and Doxorubicin for Treatment of Acute Myeloid Leukemia /

By Idrees, Nimra . . 102p. 30cm.

Place Hold on Nanoencapsulation of Ferrocene Incorporated Thiourea and Doxorubicin for Treatment of Acute Myeloid Leukemia /

Detecting Musculoskeletal Co-contraction for Ankle Rehabilitation through Variational Mode Decomposition in sEMG /

By Yasmeen, Sania . . 56p. 30cm.

Place Hold on Detecting Musculoskeletal Co-contraction for Ankle Rehabilitation through Variational Mode Decomposition in sEMG /

Elucidation of Therapeutic Potential of Caffeine Nanoparticles against Acute Myeloid Leukemia / Usama Sabir

By Sabir, Usama. . 88p. 30cm.

Place Hold on Elucidation of Therapeutic Potential of Caffeine Nanoparticles against Acute Myeloid Leukemia /

Evaluation of the anti-cancerous effect of ciprofloxacin loaded liposomes against leukemia in rat model /

By Fatima, Sahar. . 86p. 30cm.

Place Hold on Evaluation of the anti-cancerous effect of ciprofloxacin loaded liposomes against leukemia in rat model /

Potential Inhibition of Lactate Dehydrogenase by Oxamate in Enterococcus faecalis /

By Raza, Laiba Hareem . . 72p. 30cm.

Place Hold on Potential Inhibition of Lactate Dehydrogenase by Oxamate in Enterococcus faecalis /

Biomineralization of PET (Polyethylene terephthalate) plastic through Sporosarcina species for plastic waste management /

By Kamran Shahzad, Muhammad . . 48p. ; 30cm..

Place Hold on Biomineralization of PET (Polyethylene terephthalate) plastic through Sporosarcina species for plastic waste management /

Role of Nucleobindin 1 in Clozapine-Induced Neuroprotection in MPTP-Treated Mice Models /

By Bhatti, Rohama Makmas . . 64p. 30cm.

Place Hold on Role of Nucleobindin 1 in Clozapine-Induced Neuroprotection in MPTP-Treated Mice Models /

Characterization of the Role of Neurexin-1 in MPTP Induced Parkinsonism in Mice Model /

By Naeem, Mahnoor . . 62p. 30cm.

Place Hold on Characterization of the Role of Neurexin-1 in MPTP Induced Parkinsonism in Mice Model /

Plug and play: nnUNet for the Auto-Segmentation of Head & Neck Tumors and Lymph Nodes on 3D FDG PET/CT Scans /

By Basharat, Sonia . . 35p. 30cm.

Place Hold on Plug and play: nnUNet for the Auto-Segmentation of Head & Neck Tumors and Lymph Nodes on 3D FDG PET/CT Scans /

Brain Tumor Segmentation using CT Hybrid

By Siddiqah, Mariyam . . 30p. 30cm.

Place Hold on Brain Tumor Segmentation using CT Hybrid

Effects of Cassia Angustifolia and Nigella Sativa for the prevention of Diabetic Neuropathy /

By Khan, Mahum. . 81p. 30cm.

Place Hold on Effects of Cassia Angustifolia and Nigella Sativa for the prevention of Diabetic Neuropathy /

Therapeutic Potential of Rutin-Bound Glucose Carbon Dots for Alzheimer’s Disease /

By Khan, Sana. . 76p. 30cm.

Place Hold on Therapeutic Potential of Rutin-Bound Glucose Carbon Dots for Alzheimer’s Disease /

Early Diagnosis of AD by Detecting Amyloid-Beta in the Retina of AD-Induced Mice Using IR Spectroscopy /

By Waheed, Zuha. . 66p. 30cm.

Place Hold on Early Diagnosis of AD by Detecting Amyloid-Beta in the Retina of AD-Induced Mice Using IR Spectroscopy /

Mental Workload on the Children in Multilingual Environment /

By Niazi, Anum . . 56p. 30cm.

Place Hold on Mental Workload on the Children in Multilingual Environment /

Isolation, Phytochemical Analysis and Antibacterial Activity of Rumex acetosella Plant /

By Abbasi, Zoya Orangzeb . . 62p. 30cm.

Place Hold on Isolation, Phytochemical Analysis and Antibacterial Activity of Rumex acetosella Plant /

Evaluating Antibacterial And Wound Healing Activity Of Rumex acetosella Leaves /

By Fareed, Laraib. . 60p. ; 30cm..

Place Hold on Evaluating Antibacterial And Wound Healing Activity Of Rumex acetosella Leaves /

Development and Characterization of Biomaterials for Biomedical Applications /

By Zahra, Fatima . . 53p. 30cm.

Place Hold on Development and Characterization of Biomaterials for Biomedical Applications /

Prevention of Diabetes-Associated Cognitive Impairment through the Administration of Herbal Products /

By Riaz, Hibba. . 67p. ; 30cm..

Place Hold on Prevention of Diabetes-Associated Cognitive Impairment through the Administration of Herbal Products /

Cannabinoid Extract Protects Against Valproic Acid Induced Autism Spectrum Disorder /

By Ali, Faiza. . 79p. ; 30cm..

Place Hold on Cannabinoid Extract Protects Against Valproic Acid Induced Autism Spectrum Disorder /

Synthesis and Characterization of pH-Sensitive Smart Patch for Anti- Hypertensive Drug /

By Azhar, Maleeha. . 64p. ; 30cm..

Place Hold on Synthesis and Characterization of pH-Sensitive Smart Patch for Anti- Hypertensive Drug /

Development and Characterization of DNA-based Kit for Cancer Diagnosis /

By Fatima, Areej. . 74p. ; 30cm..

Place Hold on Development and Characterization of DNA-based Kit for Cancer Diagnosis /

Animal and clinical study for Treatment of Asthma using Intranasal inhalation of Himalayan salt /

By Tariq, Ayesha . . 56p. 30cm.

Place Hold on Animal and clinical study for Treatment of Asthma using Intranasal inhalation of Himalayan salt /

Mobile Tablet Base Therapies for Cognitive Rehabilitation of Stroke Patients /

By Shad, Amna. . 66p. ; 30cm..

Place Hold on Mobile Tablet Base Therapies for Cognitive Rehabilitation of Stroke Patients /

Multimodal Segmentation of Brain tumor using BraTS dataset 2020 /

By Saeed, Aniqa . . 60p. ;

Place Hold on Multimodal Segmentation of Brain tumor using BraTS dataset 2020 /

Genetic Screening for the Prevalence of PRNP Mutations in Pakistan /

By Khalid, Minahil . . 83p. , Prion diseases are highly contagious, rapidly progressive, and extremely life-threatening neuronal condition. CJD is the prime example of prion disease. Many cases of CJD have been reported up till now. It can be acquired, inherited or sporadic in nature. sCJD accounts for the highest prevalence globally i.e., 85% of the cases, gCJD encompasses 10-15% of the cases whereas iCJD cases include 1-2%. Its long incubation period (10-12 years) and short disease duration (3-12 months) makes it difficult to diagnose, which has contributed to higher death toll since its occurrence. World organizations are strictly monitoring CJD cases, in order to curtail the spread of this fatal disease but they are far behind in eradicating it completely. Hence it is imperative to identify CJD sources to reduce the number of cases. Therefore, this present research is the first initiative to assess the prevalence of CJD in Pakistani population. Results of this study indicated absence of mutation at codon 200 in the participants under study. Most prevalent genotype were M129-E200 (71%) and V129-E200 (29%) whereas M129-K200 and V129-K200 were absent in the participants. In parallel study a survey encompassing questions related to cognitive impaired just like CJD was also carried out to assess public knowledge regarding it. Results indicated that educated groups lacked knowledge in theoretical as well as non-theoretical aspects of CJD. This study is highly significant as it provides preliminary data on the susceptible cases of CJD and proof that the public knowledge also corresponds to the data gathered by genetic screening 30cm.

Place Hold on Genetic Screening for the Prevalence of PRNP Mutations in Pakistan /

Assessment of APOE Genotype in Pakistani Population with Relevance to Rapidly Progressive Alzheimer’s Disease /

By Rasheed, Urwah. . 68p. , According to the statistics provided by World Health Organization (WHO), approximately 55 million people are suffering from dementia globally making it a major public health concern. Alzheimer’s Disease (AD) is the most common cause of dementia constituting 60-70% of cases worldwide. There are various environmental and genetic risk factors that contribute to the development of AD, among the genetic risk factors, APOE polymorphism is the major risk factor for AD. There are three isoforms of APOE gene E2, E3, and E4. The presence of different isoforms of APOE gene in different genotypical combinations determine how susceptible is the person to developing AD in the future. AD affects the patient’s quality of life severely and makes even basic chores undoable, therefore it is imperative for people to be aware of the disease and stay clear of the myths surrounding it. The present study is the first one to assess the presence of APOE genotype in Pakistani population with relevance to AD, no study of this sort has been carried out in Pakistan before. The results showed complete absence of E2 allele in the tested population size. The most prevalent allele was E3 which was expressed in the form of E3E3 (95%) and E3E4 (5%) genotypes. E4/E4 genotype was also completely absent. In this study, a detailed survey was also conducted to assess the knowledge of AD in Pakistani people. In certain non-technical areas, the respondents exhibited good knowledge about the AD, but in the technical aspects where risk factors, diagnostic criteria and treatment options related to the disease were involved, the participants displayed poor knowledge, this shows that even the educated people in Pakistan are unaware about the basic knowledge of the disease. It is imperative to establish organizations that can create awareness among the masses regarding AD which is exponentially increasing in Pakistan. 30cm.

Place Hold on Assessment of APOE Genotype in Pakistani Population with Relevance to Rapidly Progressive Alzheimer’s Disease /

Comparison of a Human Portable Blood Glucose Meter and Automated Chemistry Analyzer for Measurement of Blood Glucose Concentrations in Human Diabetic Patients /

By Asad-Ur-Rehman. . 46p. , Diabetes is the most prevalent chronic metabolic disorder in Pakistan which is characterized by an increased Blood Glucose level. An accurate diagnosis of diabetes is very essential for its early detection and treatment. Almost 90\% of the cases are of Type II Diabetes and the patients are required to continuously monitor their Blood Glucose level to maintain a near-normal range of Blood sugar. A practical way to monitor sugar levels is using a portable Glucometer at home which is faster and more convenient for diabetes patients. The purpose of this study is to compare Blood Glucose levels measured using Oxidase Method and a Portable Glucometer with reference Hexokinase Method in Type II Diabetes patients to determine if Glucometers can be used as a home-based selfmonitoring device. A cross-sectional study was conducted with a total of 150 Type II Diabetes patients. Blood samples were collected from the capillary of fingers for a portable Glucometer and from veins for Hexokinase and Oxidase Plasma methods after overnight fasting of 8 hours. Independent t-test and Pearson Correlation were used to check the significance of our results. There was no statistically significant difference in Blood Glucose readings obtained from Oxidase Method (128.31 + 61.4, p = 0.947) and Glucometer (122.53 + 59.6, p = 0.370) with Reference Hexokinase Method (128.78 + 61.2). A statistically significant positive correlation was observed in both methods with reference Hexokinase Method. Glucometer readings positively correlate with Hexokinase, showing that Glucometer can be used as a home-based self-monitoring Blood Glucose Device. 30cm.

Place Hold on Comparison of a Human Portable Blood Glucose Meter and Automated Chemistry Analyzer for Measurement of Blood Glucose Concentrations in Human Diabetic Patients /

Deploying Efficient Net (BNs) for grading Diabetic Retinopathy severity levels from fundus images /

By Batool, Summiya . . 40p. , One of the common and escalating endocrine illnesses is diabetes mellitus. Diabetic retinopathy is a common eye problem in patients with diabetes. Diabetic retinopathy (DR), a retinal condition, is acknowledged as an epidemic on a global scale. One-third of the estimated 285 million persons with diabetes show symptoms of DR, and one-third of them have DR that threatens their vision [1]. In addition, the figures are rising. By 2040, 288 million individuals are expected to have AMD, and by 2050, the number of people with DR is projected to treble. The need for reliable diabetic retinopathy screening systems became a critical issue recently due to the increase in the number of diabetic patients. The severity of DR can be graded into five stages: normal, mild NPDR, moderate NPDR, severe NPDR, and PDR. Early diagnosis and treatment of DR can be accomplished by organizing large regular screening programs. Numerous Convolutional neural network models are developed for the diagnosis of DR in fundus images using deep learning methods. In Deep Learning (DL) one of the methods is a computer-aided medical diagnosis for the detection of DR. There are many DL-based methods such as restricted Boltzmann Machines, convolutional neural networks (CNNs), auto-encoder, and sparse coding. On the other hand, it is thought-provoking to distinguish it initially not display signs in the initial classes. The current models for diabetic retinopathy mayn’t identify entire classes of DR. The utmost commonly used metrics like accuracy, f1-score, precision, and recall; do not cogitate the standard of difference among labels, which supports spotting all classes of DR. In our paper used Efficient Net BNs models. We concluded evaluation scores using the F1-score, which is applicable for grading various classes of DR established on the intensity levels. We have accomplished the F1- score of 0.88 and 0.84 using the simple preprocess, Gaussian smoothing filters, and deploying an Efficient Net BNs network on DeepDRiD and EYE-PACS datasets. 30cm.

Place Hold on Deploying Efficient Net (BNs) for grading Diabetic Retinopathy severity levels from fundus images /

Synthesis, Characterization and Application Of Natural Nano Composites /

By Tariq, Faiza . . 71p. , The use of natural polymers in the creation of skin wound dressings has gained attentionfor its potential to speed up healing and protect against pathogens. In this study, theability of the Papaver somniferum plant to heal wounds in various forms, suchas pureplant extract, plant-derived silver nanoparticles, and their inclusion in a polyvinyl alcohol hydrogel, was investigated. Characterization of the compounds was done usingUVspectrophotometry, X-ray diffraction, Fourier transform infrared spectroscopy, scanningelectron microscopy, and energy dispersive spectroscopy. Antimicrobial tests showedthat silver nanoparticles had a zone of inhibition of 12mm against Staphylococcus aureus, while the silver nanoparticle hydrogel had a zone of inhibition of 23mmagainst Klebsillapneumonia. The zone of inhibition by the plant extract was 11mmagainst Staphylococcus aureus, while the plant extract gel had a zone of inhibition of 16mmagainst Staphylococcus aureus. The results suggest that the bio-composite patches createdfrom these materials have potential to work against both gram-positive andgram-negative bacteria. In a mouse model, the wound healing capacity was highest for thesilver nanoparticle gel, with a wound closure of 1.7mm. Histological analysis alsoshowed that the silver nanoparticle hydrogel had excellent wound repair properties. Overall, the study suggests that pure AgNPs and bio-composite hydrogel of AgNPs haveefficient and quick healing of wounds as compared to the plant extract and plant nanocomposites hydrogel. 30cm.

Place Hold on Synthesis, Characterization and Application Of Natural Nano Composites /

Effect of Etoposide loaded Nanoparticles in the Treatment of Advanced Liver Diseases /

By Iqbal, Zarqa . . 76p. , Advanced liver diseases (ALD) continue to pose significant health challenges due to their high global prevalence and limited currently available curative options, besides liver transplantation. Liver disease therapeutics include many substances that may have insufficient effectiveness and severe adverse effects, such as Etoposide, having toxic nature with low compatibility and solubility in an aqueous solution. Nanoparticle-based therapeutics emerged as an efficient and safe treatment option to minimize side effects. Etoposide used for ALD is more toxic with low biocompatibility and solubility in an aqueous solution which makes it less efficient. The purpose of the study is to use nanoparticle-based etoposide for the treatment of ALD by improving its biocompatibility and solubility which makes this target-based therapy less toxic and more effective. Rat models used in this study were introduced with CCL4 and Urethane co-administration to develop liver cirrhosis. The thin film hydration method was used to synthesize etoposideencapsulated liposomal nanoparticles. The stability and stealth effect of liposomes were enhanced by polyethylene glycol (PEG) coating. Etoposides and PEG-coated etoposide liposomes were administered intravenously, into diseased rats. Results showed that etoposide and PEG-coated liposomal encapsulation are highly effective as compared to etoposide alone and blank nanoparticles and hence, be a substantial strategy for the treatment of ALD through intravenous drug delivery system. 30cm.

Place Hold on Effect of Etoposide loaded Nanoparticles in the Treatment of Advanced Liver Diseases /

Formation of Ciprofloxacin Loaded Transethosomes to Check the Antibacterial Activity Against Skin Infections /

By Tariq, Huraira. . 67p. , One of the serious challenges in the treatment of infectious diseases is the presence of bacterial infections in subcutaneous wound tissue. Staphylococcus epidermidis (S. epidermidis) and Propionibacterium acne (P. acne) are resistant bacterial strains that cause severe disease in humans when penetrating the deeper layer of skin. Antibacterial drugs with a nonspecific target have more difficulty in penetrating the deeper layer of infected skin. Broad spectrum antibiotics are best to treat the infection but are not commonly used because bacteria’s make resistance against them. To overcome these issues, a combined strategy of broad-spectrum antibacterial drug and nanoparticle was formulated for targeted delivery, enhanced penetration to the infection site specifically. The ciprofloxacin was entrapped in transethosomes and formulation was synthesized by using the cold method. Transethosomes are very small in size that can reach the deeper layer of skin to give potential effects. In the layers of skin, ciprofloxacin works by binding to the enzymes topoisomerase IV and DNA gyrase and inhibit the DNA replication in bacteria. The antibacterial activity of ciprofloxacin loaded transethosomes against skin infections was assessed using Staphylococcus epidermidis and Propionibacterium acne and the method used was well diffusion method. The characterization of ciprofloxacin loaded transethosomes was done through, zeta potential, particle size evaluation, and drug release efficiency. Loaded transethosomes displayed substantially have more potential effect than ciprofloxacin alone. The in-vitro studies show that ciprofloxacin loaded transethosomes boost the antibacterial activity of ciprofloxacin against gram positive. 30cm.

Place Hold on Formation of Ciprofloxacin Loaded Transethosomes to Check the Antibacterial Activity Against Skin Infections /

Bone X-ray abnormality detection using MURA dataset /

By Batool, Sana. . 40p. , Musculoskeletal abnormalities along with bone fractures are a wide range of abnormalities that account for most visits of patients to Emergency department of hospitals. According to an estimate, more than 1.7 billion people are affected by musculoskeletal disorders each year. Bone X-rays are the first line imaging modality for imaging of fractured bones. Radiologists then undergo reporting of X-rays for detection of fractures and pathologies. Classification of bone X-rays into normal and abnormal is a time-taking process and is also subjected to variability between different radiologists. Therefore, the use of automatic classifiers incorporating deep learning algorithms is currently in use in clinical diagnostics. MURA is a large publicly available dataset released by the machine learning group of Stanford university. MURA dataset consists of 40,895 multi-view images of upper limb that belong to seven regions namely shoulder, humerus, elbow, forearm, wrist, hand, and fingers. In this study we propose the use of the single DenseNet-169 model trained on complete dataset along with multiple preprocessing and data augmentation steps, based on Keras in TensorFlow. Training data was divided into 80:20 for training and validation respectively, whereas, testing of model was done on validation set. The results obtained through the proposed technique include 80% testing accuracy. This validates the effectiveness of this method for bone fractures classification. 30cm.

Place Hold on Bone X-ray abnormality detection using MURA dataset /

Targeting Microtubule-associated Protein Tau (MAPT) Interactors for Novel Therapeutic Interventions for Rapidly Progressive Alzheimer’s Disease /

By Fatimah. . 74p. , Rapidly Progressive Alzheimer's disease (rpAD) is a disease characterized by rapid cognitive loss. It progresses quickly over the course of weeks to months and sometimes may take up to two to three years. It’s rare and difficult to diagnose although accurate diagnosis is extremely crucial for its treatment. Recent evidence suggests Tau as a promising therapeutic agent for the development of disease-modifying drugsfor rpAD due to the involvement of Tau abnormalities in rpAD neurodegeneration. To determine whether Tau is a suitable therapeutic target, in silico tools were used to analyse the interaction of proteins isolated by Tau IP. It is identified that proteins interact with MAPT during the pathology of disease and play a role in progression of rpAD. The specific interaction between the MAPT region belonging from the MTB domain 2MZ7 and its interactors Neuromodulin, Synaptophysin and RhoA were investigated using molecular docking and visualization tools like PyRx, PyMOL, Discovery Studio, and LigPlot+ and binding energies and bonding between the amino acids was observed and evaluated. Protein network analysis revealed an aberration towards apoptotic pathway and signaling pathway. Furthermore, binding of different drug compounds including Methamphetamine, Ascorbic acid and Doxorubicin were evaluated through docking in silico. Doxorubicin showed the highest binding energy of -6.0 kcal/mol with 2MZ7. These drug compounds and their interaction with 2MZ7 yielding high binding affinity shows that binding site of MAPT can be blocked using Doxorubicin to prevent the interaction of pathological proteins that are involved in the accelerated progression of rpAD. 30cm.

Place Hold on Targeting Microtubule-associated Protein Tau (MAPT) Interactors for Novel Therapeutic Interventions for Rapidly Progressive Alzheimer’s Disease /

Targeting Dihydrolipoamide Dehydrogenase (DLD) Interactors for Novel Therapeutic Interventions for Alzheimer’s Disease /

By Choudhary, Jawaria . . 72p. , Alzheimer's disease is the one of the most common type of dementia, which affects millions of people worldwide. Severe memory loss is a defining feature, with episodic memory being particularly damaged in the initial stages. The majority of occurrences of Alzheimer's disease are random, while risk is increased if specific susceptibility genes are inherited. Alzheimer's disease is linked to a decline in energy metabolism, but it is unclear whether this decline worsens or prevents the condition. The finding that genetically dihydrolipoamide dehydrogenase (DLD) is associated to the late-onset AD serves as further evidence for the significance of energy metabolism in AD. To determine if DLD is an appropriate therapeutic target, in silico tools have been used in our study to analyse the interaction of DLD with CAND1, LAMP1, and TPP1 using molecular docking and visualization tools like PyRx, PyMOL, Discovery Studio, and Ligplot++. It was observed that binding sites of 5NHG are surrounded by 68 amino acids, and CAND1 (1191-1200), LAMP1 (216-225), and TPP1 (546- 555) were able to interact with the amino acids inside the binding pocket of 5NHG. Protein network analysis showed aberration towards apoptosis. In our study, we also evaluated the binding of ascorbic acid, acetaminophen, and methamphetamine after docking experiment to find therapeutic potential. Ascorbic acid and acetaminophen showed the highest binding energy with 5NHG. The interaction of these drug compounds with 5NHG yielding high binding affinity shows that these compounds can be used to block the binding sites on DLD to prevent the interaction of pathological proteins with DLD that are involved in the up-regulation or down-regulation of DLD in diseased state. 30cm.

Place Hold on Targeting Dihydrolipoamide Dehydrogenase (DLD) Interactors for Novel Therapeutic Interventions for Alzheimer’s Disease /

LIPOSOMAL DOXORUBICIN FOR THE TREATMENT OF ADVANCED LIVER DISEASE /

By Khan, Faryal . . 59p. , Nanoscale materials are utilized as diagnostic instruments or to administer therapeutic substances to specific targeted regions in a controlled manner in the fields of nanomedicine and nano drug carriers, which are still relatively young but are quickly evolving. Nanoparticles can potentially deliver medications more accurately because they are currently made from biocompatible materials. The treatment of advanced liver disease has benefited greatly from nanomedicine in previous decades. Nano-based drug delivery systems improve the effectiveness of medications. Today, advanced liver disease is being treated with liposomal nanoparticles. Nano-based drug delivery systems increase the efficacy of both new and existing treatments through a detailed investigation of nanoparticle manufacturing and utilization. One of the most often used anticancer medications is doxorubicin. Doxorubicin (DOX) is a medication that is frequently used to treat HCC. Doxorubicin is a medicine that belongs to the anthracyclines class and is commonly used to treat different types of cancers, including lymphomas, leukemias, breast, ovary, thyroid, and lungs. Doxorubicin interacts with nitrogen - containing bases of DNA and prevents the production of macromolecules. This, in turn, prevents the action of the enzyme topoisomerase II (Top II), which inhibits the replication process. Consequently, malignant cells are prevented from proliferating. According to early research, doxorubicin's cardiotoxicity is reduced when it is encapsulated inside liposomes. Due to its cardiotoxicity, the "thin film hydration approach" was utilized to create doxorubicinencapsulated liposome nanoparticles, which were then used to treat advanced liver disease. The liposome nanoparticles were coated with polyethylene glycol (PEG) to boost their stability and provide a stealth effect. Pegylation improves steric repulsion and is therefore regarded as a superior stabilizer for various kinds of nanoparticles. PEG adopts the drug's erosion-controlled release mechanism, which led to continuous release. It is noted that a significant technique to treat NAFLD is to encapsulate the doxorubicin drug within liposomes and modify these liposome nanoparticles via PEG. 30cm.

Place Hold on LIPOSOMAL DOXORUBICIN FOR THE TREATMENT OF ADVANCED LIVER DISEASE /

Validation of Antibacterial Activity of Gossypol against Enterococcus faecalis /

By Rasool, Misbah . . 54p. , Antibiotic resistance is a growing concern today that affects the entire world, necessitating the development of new antibacterial medications. Nosocomial infections pose a serious challenge for patients and hinder effective treatment. The second most common cause of nosocomial infections is Enterococcus faecalis, and it depends on the lactate dehydrogenase enzyme's capacity to maintain redox balance for growth, resistance, and virulence. As demonstrated before by computational technique, our study attempted to assess the antibacterial effect of Gossypol on Enterococcus faecalis by inhibiting Lactate Dehydrogenase Enzyme. We used six different stressors, including 0.01% SDS, 2.5mM H2O2, 8% Ethanol, 10% DMSO, 10% Glucose, and 0.25% HOCl, in addition to our inhibitor Gossypol. Gossypol was employed in the following concentrations: 5, 10, 25, 50, 75, 100, 150, 200 micrograms per milliliter using a large test tube method, absorbance on a UV-visible spectrophotometer, and on a microscale using a 96-well flatbottom plate with a Microplate reader. Between control (Culture Media) and vehicle control, which is DMSO, there is no discernible difference. At higher dosages of Gossypol, such as 100 and 200 micrograms per milliliter, there is significant growth inhibition; nevertheless, 5, 10, 25, 50, 75, and 100 micrograms per milliliter show no significant inhibition. Minimum Inhibitory Concentration is 100 microgram per milliliter. We used our six different stress factors with MIC value of Gossypol. There is no discernible growth inhibition when Gossypol is employed in conjunction with stress factors such 0.01% SDS, 2.5mM H2O2, and 0.25% HOCl. However, at 100 micrograms per milliliter at the fourth and fifth hours, glucose 10% exhibits a strong inhibitory impact, though not by a great deal. Along with MIC value of Gossypol, 100 micrograms per milliliter, 8% ethanol and 10% DMSO significantly slowed the development of the bacteria. The lactate dehydrogenase enzyme in Enterococcus faecalis was effectively inhibited by gossypol. Future in vivo studies are required to demonstrate the antibacterial activity of Gossypol in greater detail, as well as to compare it to antibiotics as an adjunctive treatment. 30cm.

Place Hold on Validation of Antibacterial Activity of Gossypol against Enterococcus faecalis /

Prevalence of APP-associated novel polymorphism in Pakistani Population /

By Maryam, Ammara . . 70p. , Alzheimer’s disease is a prevalent neurodegenerative disease characterized by dementia occurs in aged individuals. The report of prevalence of AD showed that AD and dementia patients are estimated as 35.6 million in 2010 and this number can reach up to 66 million by 2030. The present study is the first one to assess the presence of APP genotype in the Pakistani population with relevance to AD, and structural analysis of wild type APP, 710 (V>G) and 718 (I>L), and 720 (L>S) mutated APP with ligands (BACE1, ADAM10, and Nicastrin). No study of this sort has been carried out in Pakistan before. The in silico results showed that mutated APP at 718 codon interacts with serine residue of BACE1, and tyrosine residue with Nicastrin. Change in these residues cause protein to undergo aberrant denaturing and results in generation of amyloids due to differential binding of mutated APP protein with ligands in AD. SNP analysis showed the prevalence of 718 (I>L) mutation in 4% of studied population. Symptoms of 718 (I>L), mutation in APP are Hippocampus atrophy, dementia with remarkable oral tendency, and Amnesia. It is imperative to establish organizations that can create awareness among the masses regarding AD which is exponentially increasing in Pakistan. 30cm.

Place Hold on Prevalence of APP-associated novel polymorphism in Pakistani Population /

Post-Discharge symptoms and analysis for COVID-19 patients /

By Shahjehan, Ayesha . . 65p. , Coronavirus was initially recognized as human COVID by researchers in 1965. Different strains of coronavirus appeared in the following years MERS, SARS-1. Thousands of cases were reported in individuals that to led many casualties, in 2019. New strains of coronavirus emerged, known as covid-19that started to spread from Wuhan, China. It was labeled a worldwide epidemic by the World Health Organization (WHO) in March 2020, the first since 2009. Patients with covid-19 experienced gentle to extreme indications like fever, cough, weariness, shortness of breath, migraine, loose bowels, nausea, and vomiting. As SARS cov-2 is a novel infection, initially the infected patients were treated in a single room along with the utilization of antiviral medication, including oseltamivir, ribavirin, and ganciclovir, lopinavir, and ritonavir to decrease the viral burden. Indications during the contamination may not resolve unexpectedly grumble about persistent side effects, even a long time after the disease. The research is based on observing the symptoms of COVID and postCOVID in patients who perform PCR tests at a hospital. Sample of 26 males and 34 females. Services were taken and their symptoms were noted during and after the quarantine. During the assessment of the covid-19 pandemic, it was seen that overall unexpected issues have gotten even after the onset of intensive covid-19. The prolonged aftereffect stays unexplained. The point of this examination is to represent the persistent symptoms in patients who were released from the health center and to explore the related element of danger. The impact of the study is fundamental in investigating the components and potential persistent post-COVID disorder. It presents a system of procedures for prognosis and handling of patients with suspected or affirmed persevering post-COVID conditions. 30cm.

Place Hold on Post-Discharge symptoms and analysis for COVID-19 patients /

EXPLORING ASSOCIATED SIGNALLING PATHWAYS IN THE DEVELOPMENT OF SKIN CANCER AND NEUROLOGICAL DISORDERS /

By Iftikhar, Musawira. . 65p. ;

Place Hold on EXPLORING ASSOCIATED SIGNALLING PATHWAYS IN THE DEVELOPMENT OF SKIN CANCER AND NEUROLOGICAL DISORDERS /

DECISION SUPPORT SYSTEM FOR BONE FRACTURE DETECTION USING IMAGE PROCESSING TECHNIQUES /

By FAROOQ ,NAJWA . . 51p. ;

Place Hold on DECISION SUPPORT SYSTEM FOR BONE FRACTURE DETECTION USING IMAGE PROCESSING TECHNIQUES /

Computational Analysis for Prediction of Potential Inhibitors of Lactate Dehydrogenase Enzyme of E.faecalis /

By Matloob, Muhammad . . 96p. ;

Place Hold on Computational Analysis for Prediction of Potential Inhibitors of Lactate Dehydrogenase Enzyme of E.faecalis /

Computational Analysis for Prediction of Potential Inhibitors of Lactate Dehydrogenase Enzyme of E.faecalis /

By Matloob, Muhammad . . 96p. ;

Place Hold on Computational Analysis for Prediction of Potential Inhibitors of Lactate Dehydrogenase Enzyme of E.faecalis /

Indigenous Design and Development of an Industrial Electrochemical Polishing System for MDDC Production Line of Coronary Stents /

By Sehar, Zainab . . 72p. ;

Place Hold on Indigenous Design and Development of an Industrial Electrochemical Polishing System for MDDC Production Line of Coronary Stents /

SYNTHESIS AND CHARACTERIZATION OF PEG CAPPED TAMOXIFEN LOADED ZINCOXIDE NANOPARTICLES AND THEIRTHERAPUTIC APPLICATIONS /

By MALIK , MAHNOOR. . 54p. ;

Place Hold on SYNTHESIS AND CHARACTERIZATION OF PEG CAPPED TAMOXIFEN LOADED ZINCOXIDE NANOPARTICLES AND THEIRTHERAPUTIC APPLICATIONS /

Human Placental-Derived Extracellular Matrix Sheets as Scaffolds for Cell Growth in Cornea Transplantation: A Promising Approach in Regenerative medicine /

By Khan, Unaiza Ali . . 121p. , Eye is a sensory organ designed for human vision. Its intricate components work together to make the process of sight possible. The cornea is a critical part of the eye responsible for clear vision, and corneal diseases or injuries can lead to visual impairment or blindness. However, the limited availability of suitable donor tissue poses a significant challenge. There is a significant influence on the quality of life when the visual acuity is reduced. In terms of the overall prevalence of blindness and visual impairment Pakistan ranks third position, following the India and Bangladesh across all age groups, totaling 21.78 million. Placenta-derived extracellular matrix (ECM) sheets have become an effective therapeutic approach due to their rich composition of bioactive molecules, growth factors, and supportive microenvironment for tissue regeneration. The unique composition of placental-derived ECM sheets can provide a favorable microenvironment for the growth of corneal cell and promote the regeneration of corneal tissue. In this study amniotic membrane sheets, have been prepared by decellularizing placental tissue and different characterization techniques have been used for a thorough examination of the human amniotic membrane. Scanning Electron Microscopy (SEM) reveals intricate surface features, while Hematoxylin and Eosin (H&E) staining provides insights into tissue architecture. Fourier Transform Infrared Spectroscopy (FTIR) offers a detailed examination of biochemical composition. Microbial activity testing provides valuable information of the membrane's antimicrobial properties. A p-value < 0.05 in the ANOVA analysis indicated a significant difference in antimicrobial activity among the three bacterial strains. The characterization approaches utilized in this study contribute to a betterxx knowledge of the biological characteristics of the human amniotic membrane, paving the path for advances in regenerative medicine and tissue engineering. In this study a human placental-derived extracellular matrix (ECM) sheets have been used to investigate the integration potential of the ECM sheets with host corneal tissue. The positive outcome was associated with a noticeable reduction in size of corneal defect due to the application of amniotic membrane transplant. The use of AM proved to be essential in reducing notable subjective symptoms like pain, as well as clinical signs such as redness and the size of corneal ulcers. 30cm.

Place Hold on Human Placental-Derived Extracellular Matrix Sheets as Scaffolds for Cell Growth in Cornea Transplantation: A Promising Approach in Regenerative medicine /

Development of UV Stabilizing Biomedical Textile by LbL Coating of Tinuvin-622 Polymeric Nanoparticles /

By Saleem Akhtar, Hurria . . 81p. ; 33cm..

Place Hold on Development of UV Stabilizing Biomedical Textile by LbL Coating of Tinuvin-622 Polymeric Nanoparticles /

Essential Oil (Eo) Blend Loaded Solid Lipid Nanoparticles (Slns) As Novel Deodorant /

By Zahra Rehman, Zahra Rehman. . 66p. , Human odors have been of great concern to society. The generation of malodor on the skin surface of modern humans is caused by the biotransformation of naturally secreted non-odorous precursor molecules into volatile odorants by members of the commensal microbiome. Culture-based microbiological studies revealed that the axillary microbiota consists primarily of Gram-positive bacteria of the genera Staphylococcus, Corynebacterium, and Propionibacterium. Currently there is need to study the selective suppression of the growth of microorganisms involved in diseases and unpleasant odors may result in the establishment of a good symbiotic relationship between microorganisms and humans. As the growth of axillary microbiota which causes odor can be controlled by several ways including hygiene and antimicrobial skin friendly essential oils. Given the limitations in currently available products, a deodorant/antiperspirant formulation that effectively prevents body odor without producing skin sensitivity or perceived undesirable consequences is required. Our work is the deodorant production which is made from all naturally extracted products which includes the lipid which sources from whale fish and is completely alcohol and toxins free. This deodorant is fabricated using lecithin, solid lipid nanoparticles, natural essential oils, and fragrance which are incorporated in a gel. The gel phase contains triethanolamine, TEA and Carbopol-940. TEA is used in safer limits for the polymerization of Carbopol-940 to form a clear gel. The essential oils used possess antibacterial properties which are effective against sweat bacteria. The deodorant is aluminium and parabens free as they contribute to cancer development and hormonal imbalance. 30cm.

Place Hold on Essential Oil (Eo) Blend Loaded Solid Lipid Nanoparticles (Slns) As Novel Deodorant /

In-Vivo Evaluation Of Silymarin Encapsulated Liposomal Nanoparticles In Chronic Mild Stress (Cms) Model And Depression Induced Liver Disorders /

By Fatima, Misha. . 77p. , Depression is categorized as one of the most prevalent psychological disorders that affect personal wellbeing and social life of individuals. Symptoms vary from anhedonia to suicide commitment. The molecular mechanism behind is the low concentration of neurotransmitters serotonin, dopamine and norepinephrine in central nervous system. These are primarily responsible for regulating and alleviating mood. In the chronic mild stress (CMS) model of depression, silymarin, a plant-derived polyphenolic flavonoid of Silybum marianum, elicited strong antidepressant-like action. It increased the levels of monoamines, particularly 5-hydroxytryptamine (5-HT) in the cortex and dopamine (DA) in the mice hippocampal region and prefrontal cortex. The objective of the current research was to investigate silymarin's antidepressant potential in CMS-induced depressive-like behavior in mice and to identify its potential mechanism(s) of action. The mice were given silymarin and silymarin loaded liposomal nanoparticles (SLNPs) for two weeks after following CMS protocol for 28 days (4 weeks). Animals were assessed for behavioral alterations, including exploratory activity in an open field test, behavioral despair in a forced swim test, and anxiety-like behaviors in an elevated plus maze test. There lies a close relationship between depression and inflammatory liver diseases. Hence the effect of depression on liver has also been checked. Silymarin is a commercially available hepatoprotective drug but due to its antioxidant properties, research has been conducted to evaluate its neuroprotective effect and hence its prescription as antidepressant drug. However, due to its poor solubility and bioavailability there is delay in the onset of treatment outcomes in many individuals. Certain side effects and contraindications are also important regimen opponents. In this study, Silymarin loaded liposomal nanoparticles (SLNPs) are prepared, characterized, and realized for the depression treatment in Chronic Mild Stress (CMS) mice model of depression and its treatment efficiency on symptoms of inflammatory liver diseases in mice as well. It presented face construct and validity response. As such the SLNPs present improvement in depression measurement parameters as compared to the simple silymarin. The SLNPs also positively impacted the aggression, anhedonia and rearing in mice, however simple silymarin treated mice did not show improvement in social and personal behavior. As such SLNPs compensated for delayed onset of fluoxetine response. 30cm.

Place Hold on In-Vivo Evaluation Of Silymarin Encapsulated Liposomal Nanoparticles In Chronic Mild Stress (Cms) Model And Depression Induced Liver Disorders /