Quantitative drug design : a critical introduction / Yvonne Connolly Martin.
Material type:
TextPublisher: Boca Raton : CRC Press/Taylor & Francis, c2010Edition: 2nd edDescription: xv, 282 p. : ill. ; 25 cmISBN: 9781420070996 (hardcover : alk. paper)Subject(s): -- 1.Drug Design 2. Biopharmaceutics 3. Models,Theoretical 4. Quantitative Structure-Activity Relationship | Drugs -- Structure-activity relationships | QSAR (Biochemistry) | Drugs -- Design | Drug Design | Biopharmaceutics | Models, Theoretical | Quantitative Structure-Activity RelationshipDDC classification: 615/.19 LOC classification: RM301.42 | .M37 2010| Item type | Current location | Home library | Shelving location | Call number | Status | Date due | Barcode | Item holds |
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Book
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School of Interdisciplinary Engineering and Sciences (SINES) | School of Interdisciplinary Engineering and Sciences (SINES) | General Stacks | 615/.19 (Browse shelf) | Available | RCMS003188 |
Includes bibliographical references and index.
Overview of quantitative drug design -- Noncovalent interactions in biological systems -- Preparation of 3D structures of molecules for 3D QSAR -- Calculating physical properties of molecules -- Biological data -- Form of equations that relate potency and physical properties -- Statistical basis of regression and partial least-squares analysis -- Strategy for the statistical evaluation of a data set of related molecules -- Detailed examples of QSAR calculations on erythromycin esters -- Case studies -- Methods to approach other structure-activity problems.
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