NUST Institutions Library Catalogue

Titanium implants are extensively used in the medical and healthcare industries because of their
exceptional mechanical strength and biocompatibility. However, there are still concerns with
reducing infection and enhancing implant integration with the surrounding bone tissue. In order to
improve the antibacterial and biocompatibility of titanium implants, this study prepares star like
silver nanoparticles and coat them on titanium discs (Ti-6Al-4V). The process of creating silver
nanostars involved heating polyvinylpyrrolidone (PVP) and ethylene glycol solution along with
silver precursor solution at 190°C for 30 minutes and reducing silver nitrate with 4×10⁻² M NaOH.
PVP and ethylene glycol were used to stabilize the nanostar. Different properties of nanoparticles
such as Surface morphology, functional groups, chemical composition, phase and purity, visual
characterization, surface charge and stability were characterized by using SEM, FTIR, Raman
spectroscopy, XRD, UV-Vis spectroscopy and zeta analysis. To enhance surface qualities,
titanium discs were heated and given alkaline treatments. Simulated body fluid (SBF) and
nanostar-coated discs interacted, and contact angle was measured in order to test biocompatibility.
The antibacterial efficacy of tryptic soy broth (TSB) and TSA was evaluated against
Staphylococcus aureus and there was a significant decrease in biofilm activity observed on 96 well
plate.7 days and 14 days coated disc shows 83% and 95% inhibition to biofilm and there was a
decrease in contact angle of both discs with increasing coating period, and 14 day coated disc
shows contact angle of 22° indicating high hydrophilicity that leads to better Osseo integration and
biocompatibility. These findings demonstrated that the silver nanostar coatings considerably
increased the antibiofilm activity and make titanium implants more bio absorbable, which may
promote Osseo integration and decrease bacterial adherence. This work demonstrates the effectiveness of coatings of silver nanoparticles, marking a significant advance in clinical
applications.