000			01566nam a22001577a 4500
082			_a610
100			_aMalik, Mehreen Nadeem _9122085
245			_aSaikosaponin B2 modulate oxidative stress in scopolamine induced murine model of Alzheimer’s Disease / _cMehreen Nadeem Malik
264			_aIslamabad : _bSMME- NUST; _c2022.
300			_a80p. _bSoft Copy _c30cm
500			_aOne of the initial pathological hallmarks of Alzheimer's disease is cognitive decline and memory loss by disruption of cholinergic neurons and oxidative brain damage. A postsynaptic muscarinic receptor blocker, scopolamine impairs cholinergic transmission and impairs cognition. Here, we observed the physiological processes underlying Saikosaponin b2's impact on memory deficits in mice that had been given scopolamine repeatedly. Scopolamine (1 mg/kg) administration for 15 days caused severe deficits in working and short-term memory in mice, as determined by the elevated plus maze, Morris water maze, and novel object recognition tests. However, scopolamine administered mice who were additionally given Saikosaponin b2 did not experience either deficit. This effect was associated with an increase in antioxidant enzymes (superoxide dismutase, Glutathione reductase, glutathione s transferase and catalase), followed by reduction in lipid peroxidation and myeloperoxidase activity.
650			_aMS Biomedical Sciences (BMS)
700			_aSupervisor : Dr. Adeeb Shehzad _9119503
856			_uhttp://10.250.8.41:8080/xmlui/handle/123456789/31386
942			_2ddc _cTHE
999			_c608656 _d608656