000			02526nam a22001577a 4500
082			_a610
100			_aManzoor, Saira _9122245
245			_aEnhancing the Functionality of Polyethersulfone Hemodialysis Membranes Using Water-Soluble Hydrophilic Additives / _cSaira Manzoor
264			_aIslamabad : _bSMME- NUST; _c2024.
300			_a84p. _bSoft Copy _c30cm
500			_aThe kidneys play a critical part in maintaining internal equilibrium of the body. However, renal diseases present a significant public health concern, affecting millions of individuals worldwide. Polyethersulfone (PES) based hemodialysis membranes can provide a lifesustaining treatment procedure for patients suffering from renal disease. Nevertheless, the intrinsic hydrophobic nature of PES contributes to an inefficiency of uremic toxin clearance and a compromised hemocompatibility. This work evaluates the individual and combined effects of two water-soluble hydrophilic additives, polyethylene glycol (PEG) and polyvinylpyrrolidone (PVP), on the functionality of polyethersulfone (PES) membranes. The membranes were synthesized by the non-solvent phase inversion method by using NMP as the solvent. The fabricated membranes were characterized by using Scanning Electron Microscopy, ATR-FTIR, tensile testing, porosity, and contact angle analysis. The SEM images demonstrated the successful fabrication of the membranes. Each membrane possessed a thin skin layer and an asymmetric porous framework. As a result of the synergistic effect, the membrane with dual WSP—2.5% PVP and 2.5% PEG— performed better than membranes with a single water-soluble hydrophilic additive. The membranes comprising the two additives had excellent hydrophilicity, increased porosity, and a high-water retention capacity. Moreover, they showed a urea clearance of 77.3%, a pure water flux of 96 L/m²/h, and an outstanding BSA rejection of 99.10%. RSM modelling was employed to determine the urea clearance that verified the ideal conditions for urea removal were concentrations of 1200 mg/L and 0.6 MPa. The effectiveness of membrane containing dual WSP for hemodialysis was further demonstrated by hemocompatibility xv tests, which provided promising results (APTT 32s, PT 14s, plasma recalcification time 205.5s, and hemolysis rate 1.32%).
650			_aMS Biomedical Sciences (BMS)
700			_aSupervisor : Dr. Muhammad Nabeel Anwar _9119573
856			_uhttp://10.250.8.41:8080/xmlui/handle/123456789/42792
942			_2ddc _cTHE
999			_c608763 _d608763