000			02100nam a22001577a 4500
082			_a610
100			_aSaleem, Iqra _9122403
245			_aEffectiveness of Se/ZnO NPs in enhancing antibacterial activity of resin based dental composite / _cIqra Saleem
264			_aIslamabad : _bSMME- NUST; _c2022.
300			_a65p. _bSoft Copy _c30cm
500			_aBiofilm formation in the resin-composite interface is a major challenge of resin based dental composites that may lead to secondary caries formation. The use of nanoparticles (NPs) to enhance the antibacterial properties of resin composites are highly desired. The present study focused on effectiveness of Se doped ZnO (Se/ZnO) NPs as an antibacterial nanofiller and its impact of mechanical properties of the resin composites. Pristine and Se/ZnO NPs were synthesized by the mechanochemical method, and confirmed through UV-Vis Spectroscopy, FTIR (Fourier Transform Infrared) analysis, X-ray Diffraction (XRD) crystallography, Scanning Electron Microscopy (SEM), Energy Dispersive Spectroscopy (EDS), and Zeta analysis. The resin composites were then modified by varying concentrations of pristine and Se/ZnO NPs. For the antibacterial analysis, a single specie (S. mutans and E. faecalis) and a saliva microcosm model was utilized. Hemolytic assay and compressive strength tests were also performed to test the cytotoxicity and mechanical strength of modified composite resin. 1% Se/ZnO NPs when incorporated in composite resin showed higher antibacterial activity, higher biocompatibility, and higher mechanical strength when compared to composites with 1% ZnO NPs. Mechanical strength was unaffected by addition of Se/ZnO NPs. Furthermore, the hemolytic activity was also within the safe limit. Se/ZnO NPs can be used as efficient antibacterial nanofiller for resin composites and are effective in preventing secondary caries formation.
650			_aMS Biomedical Sciences (BMS)
700			_aSupervisor : Dr. Nosheen Fatima Rana
856			_uhttp://10.250.8.41:8080/xmlui/handle/123456789/30886
942			_2ddc _cTHE
999			_c608896 _d608896